AiPD: Autoinhibited Protein Database

P04843

Gene name	RPN1
Protein name	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Names	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit, Ribophorin I, RPN-I, Ribophorin-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6184
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

477-569 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

477-569 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for P04843

Entry ID	Method	Resolution	Chain	Position	Source
6S7O	EM	350 A	E	1-607	PDB
6S7T	EM	350 A	E	1-607	PDB
8B6L	EM	760 A	O	1-607	PDB
AF-P04843-F1	Predicted				AlphaFoldDB

466 variants for P04843

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1220887069 CA354429057	2	E>G		No	ClinGen TOPMed
CA354429053 rs1266031477	3	A>T		No	ClinGen TOPMed
rs1425806742 CA354429049	3	A>V		No	ClinGen gnomAD
rs1045907278 CA82554365	4	P>A		No	ClinGen TOPMed gnomAD
rs749704337 CA2600740	4	P>L		No	ClinGen ExAC TOPMed gnomAD
CA82554360 rs749704337	4	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1045907278 CA354429047	4	P>S		No	ClinGen TOPMed gnomAD
CA354429039 rs1482450054	5	A>V		No	ClinGen gnomAD
rs1218824277 CA354429037	6	A>T		No	ClinGen TOPMed gnomAD
rs746362304 CA2600737	6	A>V		No	ClinGen ExAC gnomAD
rs1361136875 CA354429022	8	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs373598717 CA2600734	11	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	12	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1296138285 CA354428996	13	L>V		No	ClinGen TOPMed
CA354428980 rs1394233888	15	G>E		No	ClinGen TOPMed gnomAD
CA354428977 rs778452718	16	T>A		No	ClinGen ExAC TOPMed gnomAD
CA2600732 rs144093169	16	T>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs778452718 CA2600733	16	T>S		No	ClinGen ExAC TOPMed gnomAD
rs1402780123 CA354428973	17	W>R		No	ClinGen gnomAD
rs576141594 CA2600730	18	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA354428955 rs1216267742	19	P>R		No	ClinGen TOPMed
rs1369138221 CA354428950	20	A>G		No	ClinGen TOPMed gnomAD
CA354428954 rs1484482859	20	A>T		No	ClinGen TOPMed
CA354428949 rs1369138221	20	A>V		No	ClinGen TOPMed gnomAD
rs750296401 CA2600727	21	P>L		No	ClinGen ExAC TOPMed gnomAD
CA354428944 rs750296401	21	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA354428945 rs750296401	21	P>R		No	ClinGen ExAC TOPMed gnomAD
rs966631320 CA82554231	22	G>R		No	ClinGen TOPMed gnomAD
rs996220316 CA82554228	23	S>R		No	ClinGen TOPMed
CA354428930 rs1156847387	24	A>T		No	ClinGen TOPMed
rs767685550 CA2600726	25	S>F		No	ClinGen ExAC TOPMed gnomAD
CA82554226 rs554382484	26	S>P		No	ClinGen 1000Genomes TOPMed gnomAD
rs868164295 CA82554225	27	E>*		No	ClinGen Ensembl
CA354428909 rs1356368738	27	E>D		No	ClinGen gnomAD
CA82554219 rs1008831447	28	A>V		No	ClinGen TOPMed gnomAD
rs1382007432 CA354428899	29	P>L		No	ClinGen gnomAD
CA82554217 rs377310976	29	P>S		No	ClinGen 1000Genomes ESP TOPMed gnomAD
rs1309672978 CA354428893	30	P>L		No	ClinGen gnomAD
rs1450475252 CA354428898	30	P>S		No	ClinGen TOPMed
rs151009188 CA2600725	33	N>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2600724 rs151009188	33	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1271565415 CA354428870	34	E>A		No	ClinGen gnomAD
rs1391486751 CA354428866	35	D>N		No	ClinGen gnomAD
CA354428842 rs1165091655	38	R>C		No	ClinGen gnomAD
rs866036473 CA82554201	38	R>L		No	ClinGen Ensembl
CA354428835 rs1385207500	39	T>R		No	ClinGen gnomAD
CA2600722 rs763207572	40	V>A		No	ClinGen ExAC gnomAD
CA354428832 rs1441998204	40	V>L		No	ClinGen gnomAD
CA2600720 rs770275111	41	D>E		No	ClinGen ExAC gnomAD
TCGA novel	41	D>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	42	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA354428809 rs1318747283	43	S>R		No	ClinGen gnomAD
rs1291374376 CA354428804	44	S>N		No	ClinGen gnomAD
CA82554185 rs868343808	45	H>N		No	ClinGen Ensembl
CA354428788 rs1286721614	46	L>R		No	ClinGen gnomAD
CA82554177 rs1001645398	47	A>P		No	ClinGen TOPMed gnomAD
CA354428780 rs1374293090	48	K>Q		No	ClinGen gnomAD
CA82554149 rs867806791	50	T>M		No	ClinGen Ensembl
rs1294495367 CA354428763	51	A>T		No	ClinGen TOPMed gnomAD
CA82554143 rs866131234	52	E>*		No	ClinGen Ensembl
TCGA novel	52	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1427230616 CA354428753	52	E>V		No	ClinGen TOPMed
rs369177619 CA2600714	54	V>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1468432433 CA354428728	57	H>N		No	ClinGen TOPMed
CA354428723 rs1365496545	57	H>P		No	ClinGen gnomAD
rs1159722202 CA354428719	58	L>V		No	ClinGen TOPMed gnomAD
rs1466709842 CA354428715	59	G>S		No	ClinGen TOPMed gnomAD
CA2600713 rs748937023	59	G>V		No	ClinGen ExAC gnomAD
CA354428707 rs1158376265	60	G>D		No	ClinGen TOPMed gnomAD
rs13064039 CA82554128	61	G>A		No	ClinGen Ensembl
CA2600711 rs755882055	62	S>C		No	ClinGen ExAC TOPMed gnomAD
CA354428690 rs750187506	63	T>M		No	ClinGen ExAC TOPMed gnomAD
CA2600710 rs750187506	63	T>R		No	ClinGen ExAC TOPMed gnomAD
rs1490026517 CA354428685	64	S>C		No	ClinGen gnomAD
rs1263275642 CA354428683	65	R>G		No	ClinGen gnomAD
CA82554090 rs376842979	65	R>L		No	ClinGen ESP gnomAD
rs376842979 CA82554093	65	R>Q		No	ClinGen ESP gnomAD
rs1283262254 CA354428680	66	A>T		No	ClinGen gnomAD
TCGA novel	67	T>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA82554080 rs1047995254	67	T>P		No	ClinGen gnomAD
rs13064206 CA82554046	68	S>F		No	ClinGen ExAC gnomAD
rs13064206 CA2600708	68	S>Y		No	ClinGen ExAC gnomAD
rs751607930 CA354428658	69	F>L		No	ClinGen ExAC gnomAD
CA354428653 rs1321937720	70	L>Q		No	ClinGen TOPMed
COSM249338 CA2600706 rs764252299	73	L>F	kidney [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed
rs1344891575 CA354428639	73	L>S		No	ClinGen gnomAD
rs534980644 CA82554038	75	P>R		No	ClinGen 1000Genomes
CA354428612 rs1201857324	77	L>F		No	ClinGen TOPMed
rs930861339 CA82554034	79	A>D		No	ClinGen TOPMed gnomAD
CA354428592 rs1190343292	80	R>L		No	ClinGen TOPMed
rs924244119 CA82554025	80	R>W		No	ClinGen TOPMed gnomAD
rs1576801800 CA354428581	82	A>G		No	ClinGen Ensembl
rs1415459324 CA354428557	86	V>A		No	ClinGen gnomAD
rs920294633 CA82554023	87	Q>*		No	ClinGen gnomAD
TCGA novel	87	Q>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775820476 CA2600704	87	Q>L		No	ClinGen ExAC gnomAD
TCGA novel	87	Q>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	88	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA354428529 rs1377173099	89	K>R		No	ClinGen gnomAD
rs1314477985 CA354428518	91	E>K		No	ClinGen gnomAD
rs765587366 CA2600686	93	E>V		No	ClinGen ExAC gnomAD
rs754166351 CA2600684	94	E>D		No	ClinGen ExAC gnomAD
CA2600683 rs766763619	95	E>A		No	ClinGen ExAC gnomAD
CA354428484 rs1235652314	95	E>D		No	ClinGen TOPMed
CA82548996 rs376078228	95	E>K		No	ClinGen ESP TOPMed gnomAD
CA354428478 rs1406994811	96	N>I		No	ClinGen gnomAD
rs749217052 CA82548985	96	N>K		No	ClinGen TOPMed
rs761128742 CA2600682	97	N>S		No	ClinGen ExAC gnomAD
rs1182736261 CA354428452	100	V>I		No	ClinGen gnomAD
CA2600681 rs552831968	101	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA2600680 rs199783080	101	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1157120868 CA354428444	102	E>K		No	ClinGen TOPMed
rs762485457 CA2600679	108	K>E		No	ClinGen ExAC gnomAD
rs774919109 CA2600678	109	S>G		No	ClinGen ExAC gnomAD
CA354427705 rs1478223081	109	S>R		No	ClinGen gnomAD
rs774919109 CA354428393	109	S>R		No	ClinGen ExAC gnomAD
CA354427671 rs1191615052	112	F>L		No	ClinGen gnomAD
CA2600650 rs759148419	112	F>V		No	ClinGen ExAC gnomAD
CA2600649 rs776322483	114	T>A		No	ClinGen ExAC gnomAD
CA2600648 rs770438055	115	V>F		No	ClinGen ExAC gnomAD
rs1185851086 CA354427605	118	P>L		No	ClinGen gnomAD
CA354427600 rs1459695260	119	V>F		No	ClinGen gnomAD
TCGA novel	120	A>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA82541750 rs1051462122	120	A>T		No	ClinGen TOPMed
rs532321871 CA2600647	121	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs532321871 CA2600646	121	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA354427561 rs1249150101	123	P>A		No	ClinGen gnomAD
rs1241793911 CA354427531	125	A>D		No	ClinGen gnomAD
rs780355938 CA2600640	130	I>T		No	ClinGen ExAC gnomAD
rs1377161598 CA354427487	130	I>V		No	ClinGen gnomAD
CA354427458 rs1191765386	132	E>G		No	ClinGen TOPMed
CA354427433 rs1305928843	135	Y>H		No	ClinGen gnomAD
rs1398666272 CA354427414	136	T>S		No	ClinGen gnomAD
rs549601911 CA2600637	137	H>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2600636 rs757831519	137	H>R		No	ClinGen ExAC TOPMed gnomAD
rs141345041 CA82541668	141	P>L		No	ClinGen ESP TOPMed gnomAD
rs146983075 CA2600634	144	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs372892820 CA2600632	145	Q>P		No	ClinGen ESP ExAC gnomAD
CA2600630 rs760344085	148	Q>R		No	ClinGen ExAC gnomAD
rs1420140345 CA354427221	152	Q>H		No	ClinGen gnomAD
CA2600627 rs762662133 COSM3846138	155	V>E	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs762662133 CA2600626	155	V>G		No	ClinGen ExAC TOPMed gnomAD
rs758271882 CA82541570	155	V>M		No	ClinGen TOPMed gnomAD
CA2600624 rs768440696	156	F>L		No	ClinGen ExAC TOPMed gnomAD
CA2600625 rs774368360	156	F>Y		No	ClinGen ExAC gnomAD
rs779942540 CA2600622	159	N>D		No	ClinGen ExAC TOPMed gnomAD
rs987956984 CA82541481	159	N>T		No	ClinGen TOPMed
CA2600621 rs756388812	160	H>R		No	ClinGen ExAC gnomAD
CA82541473 rs370522421	160	H>Y		No	ClinGen Ensembl
rs1391559209 CA354427109	162	F>L		No	ClinGen gnomAD
CA354427117 rs1390948297	162	F>V		No	ClinGen gnomAD
CA354427086 rs1165943838	164	S>F		No	ClinGen gnomAD
CA354427068 rs1384950472	166	Y>C		No	ClinGen gnomAD
rs781580194 CA2600619	167	P>L		No	ClinGen ExAC gnomAD
CA2600618 rs757592263	168	T>M		No	ClinGen ExAC TOPMed gnomAD
CA354427048 rs757592263	168	T>R		No	ClinGen ExAC TOPMed gnomAD
rs1256988129 CA354427034	169	K>N		No	ClinGen TOPMed gnomAD
rs1212761834 CA354427037	169	K>R		No	ClinGen TOPMed
rs1361772612 CA354427029	170	T>A		No	ClinGen gnomAD
CA354427023 rs1559756589	170	T>I		No	ClinGen Ensembl
CA354427015 rs1451623554	171	Q>P		No	ClinGen gnomAD
CA2600614 rs753399733	173	M>I		No	ClinGen ExAC TOPMed gnomAD
rs368476540 CA2600615	173	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs773656479 CA82541413	173	M>V		No	ClinGen TOPMed
CA2600612 rs376709384	174	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA2600613 rs376709384	174	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs371612229 CA2600611	174	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	174	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767231053 CA2600610	175	V>M		No	ClinGen ExAC gnomAD
CA82541393 rs1022912364	176	K>R		No	ClinGen TOPMed gnomAD
CA354426949 rs1175948781	177	L>P		No	ClinGen TOPMed
CA354426930 rs1576797169	179	S>F		No	ClinGen Ensembl
rs144201770 CA2600608	180	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs768654993 CA2600607	182	V>M		No	ClinGen ExAC TOPMed gnomAD
CA2600606 rs762788388	184	S>R		No	ClinGen ExAC gnomAD
CA11557699 rs1403618431	185	Y>C		No	ClinGen gnomAD
rs769838168 CA2600604	187	K>E		No	ClinGen ExAC gnomAD
CA354426827 rs762392920	190	N>D		No	ClinGen gnomAD
rs762392920 CA82541335	190	N>Y		No	ClinGen gnomAD
TCGA novel	191	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2600602 rs781410585	191	P>S		No	ClinGen ExAC gnomAD
CA82541295 rs867881809	192	T>M		No	ClinGen TOPMed gnomAD
rs150901401 CA2600598	193	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA2600596 rs199634162	193	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA2600597 rs199634162	193	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs150901401 CA2600599	193	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1444997626 CA354426784	194	S>F		No	ClinGen gnomAD
rs755709173 CA2600595	194	S>P		No	ClinGen ExAC gnomAD
CA354426765 rs1576797128	196	D>A		No	ClinGen Ensembl
rs749913076 CA2600594	197	L>P		No	ClinGen ExAC gnomAD
CA354426737 rs1344093936	199	D>G		No	ClinGen TOPMed
rs201491933 CA82541220	202	P>L		No	ClinGen 1000Genomes
rs1200091190 CA354426707	202	P>T		No	ClinGen TOPMed
rs115466774 CA2600593	203	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2600592 rs549222889	205	D>A		No	ClinGen ExAC gnomAD
CA354426670 rs549222889	205	D>V		No	ClinGen ExAC gnomAD
CA354426651 rs1439575049	207	P>S		No	ClinGen TOPMed
rs1296488437 CA354426277	214	F>S		No	ClinGen TOPMed
rs757004043 CA2600573	216	V>I		No	ClinGen ExAC TOPMed gnomAD
CA2600574 rs757004043	216	V>L		No	ClinGen ExAC TOPMed gnomAD
CA2600572 rs751145417	217	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1408112955 CA354426250	218	Y>*		No	ClinGen gnomAD
CA2600570 rs762675522	218	Y>C		No	ClinGen ExAC gnomAD
CA2600571 rs764002311	218	Y>D		No	ClinGen ExAC gnomAD
rs752445372 CA2600569	219	E>A		No	ClinGen ExAC TOPMed gnomAD
rs1241046918 CA354426236	220	N>K		No	ClinGen gnomAD
rs765162052 CA2600568	220	N>S		No	ClinGen ExAC gnomAD
CA2600567 rs759408661	221	N>S		No	ClinGen ExAC gnomAD
CA354426196 rs1233491617	226	T>N		No	ClinGen gnomAD
CA354426187 rs1306255470	228	T>A		No	ClinGen gnomAD
CA2600565 rs190764467	228	T>I		No	ClinGen 1000Genomes ExAC gnomAD
CA354426185 rs190764467	228	T>N		No	ClinGen 1000Genomes ExAC gnomAD
CA354426188 rs1306255470	228	T>P		No	ClinGen gnomAD
CA354426159 rs1361983839	232	R>*	Variant assessed as Somatic; 4.619e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1313400925 CA354426158	232	R>Q		No	ClinGen gnomAD
CA2600563 rs773283912	234	I>V		No	ClinGen ExAC gnomAD
rs897466841 CA82535874	236	V>I		No	ClinGen gnomAD
rs897466841 CA354426135	236	V>L		No	ClinGen gnomAD
CA2600562 rs138936459	238	H>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1439470581 CA354426105	240	G>V		No	ClinGen gnomAD
rs1303618678 CA354426101	241	N>D		No	ClinGen gnomAD
rs1202935039 CA354426090	242	I>S		No	ClinGen gnomAD
CA82535848 rs1050262456	243	A>P		No	ClinGen Ensembl
rs774800395 CA2600560	244	V>A		No	ClinGen ExAC gnomAD
CA354426082 rs1383102248	244	V>M		No	ClinGen gnomAD
CA354426066 rs1409062385	246	E>G		No	ClinGen gnomAD
CA354426061 rs1281923715	247	N>H		No	ClinGen TOPMed
rs376429671 CA2600558	251	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA2600556 rs756704573	253	T>K		No	ClinGen ExAC gnomAD
CA2600557 rs148220683	253	T>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs1490996966 CA354426004	255	A>V		No	ClinGen TOPMed gnomAD
CA2600555 rs746483452	256	V>L		No	ClinGen ExAC TOPMed gnomAD
rs1317128850 CA354425974	260	P>S	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA354425954 COSM727588 rs1308628417	263	R>C	lung Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA2600553 rs185997997	263	R>H		No	ClinGen 1000Genomes ExAC gnomAD
CA2600552 rs757998521	264	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1435830756 CA354425924	267	Q>R		No	ClinGen TOPMed
TCGA novel	268	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA354425906 rs1312837786	269	Q>H		No	ClinGen TOPMed
CA354425903 rs1357967532	270	P>S		No	ClinGen TOPMed
CA2600551 rs752498769	271	D>V		No	ClinGen ExAC gnomAD
CA354425883 rs1444781439	273	G>R		No	ClinGen TOPMed
rs370420726 CA2600550	275	S>F		No	ClinGen ESP ExAC gnomAD
CA354425863 rs1454068838	276	S>C		No	ClinGen TOPMed gnomAD
rs753743515 CA2600548	276	S>P		No	ClinGen ExAC gnomAD
CA2600546 rs760701141	278	R>H		No	ClinGen ExAC TOPMed gnomAD
rs373405207 CA2600545	279	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA2600524 rs566070827	282	T>I		No	ClinGen 1000Genomes ExAC gnomAD
rs267599598 CA82534039	284	L>F		No	ClinGen Ensembl
rs764366574 CA2600523	285	P>R		No	ClinGen ExAC gnomAD
CA354425782 rs1263314391	287	A>V		No	ClinGen gnomAD
rs1350338811 CA354425759	291	V>I		No	ClinGen TOPMed
rs770212823 CA2600520	294	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA82534029 rs1012496193	294	R>W		No	ClinGen TOPMed
rs1228032632 CA354425714	297	I>T		No	ClinGen gnomAD
rs1261986233 CA354425717	297	I>V		No	ClinGen gnomAD
CA354425706 rs1325527286	298	G>V		No	ClinGen gnomAD
CA354425705 rs1309225437	299	N>H		No	ClinGen gnomAD
CA2600519 rs369220843	299	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA2600518 rs772662607	302	T>A		No	ClinGen ExAC gnomAD
rs1219057285 CA354425680	303	S>G		No	ClinGen TOPMed
TCGA novel	308	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2600515 rs778558650	312	V>I		No	ClinGen ExAC gnomAD
rs1035360109 CA82533960	314	M>I		No	ClinGen Ensembl
rs768230951 CA2600514	317	R>Q		No	ClinGen ExAC gnomAD
TCGA novel	318	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs749051807 CA2600513	319	R>C		No	ClinGen ExAC TOPMed gnomAD
CA354425569 rs1168968330	319	R>H		No	ClinGen gnomAD
rs779886802 CA2600512	321	P>L		No	ClinGen ExAC TOPMed gnomAD
rs918081424 CA82533946	322	L>R		No	ClinGen TOPMed
rs756075171 CA2600511	322	L>V		No	ClinGen ExAC gnomAD
rs750346666 CA2600510	323	F>Y		No	ClinGen ExAC gnomAD
COSM1642082 CA2600508 rs751653612 CA2600507	325	G>R	stomach [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA354425530 rs1195939760	326	W>G		No	ClinGen gnomAD
CA354425507 rs1171957453	329	H>Y		No	ClinGen TOPMed gnomAD
rs763205804 CA2600505	330	Y>C		No	ClinGen ExAC gnomAD
rs957158943 CA82533912	332	V>A		No	ClinGen TOPMed
rs1359838705 COSM1037991 CA354425487	332	V>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
COSM149464 CA2600503 rs765627715	336	L>F	stomach [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA2600502 rs759999108	336	L>P		No	ClinGen ExAC gnomAD
rs777171863 CA2600501	337	P>A		No	ClinGen ExAC gnomAD
rs1333589849 CA354425448	338	S>N		No	ClinGen gnomAD
CA354425439 rs1391977268	339	Y>C		No	ClinGen gnomAD
CA82533842 rs759202343	343	Y>C		No	ClinGen Ensembl
CA354425401 rs1194919279	344	N>I		No	ClinGen TOPMed
TCGA novel	346	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA354425369 rs1389242869	347	D>V		No	ClinGen TOPMed
rs757237896 CA82530534	348	Q>P		No	ClinGen TOPMed gnomAD
TCGA novel	350	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2600481 rs761158423	352	K>R		No	ClinGen ExAC TOPMed gnomAD
CA2600480 rs773918817	353	M>I		No	ClinGen ExAC gnomAD
rs1158748544 CA354425332	353	M>V		No	ClinGen TOPMed gnomAD
rs553124011 CA2600479	356	V>M		No	ClinGen 1000Genomes ExAC gnomAD
rs1396394781 CA354425269	361	D>E		No	ClinGen TOPMed
CA2600478 rs762564027	362	E>K		No	ClinGen ExAC gnomAD
rs1271040859 CA354425255	363	Q>L		No	ClinGen gnomAD
CA354425250 rs1220162349	364	V>E		No	ClinGen gnomAD
CA2600476 rs775232771	364	V>M		No	ClinGen ExAC TOPMed
rs1450779231 CA354425235	366	D>A		No	ClinGen TOPMed gnomAD
rs538574016 CA82530485	366	D>E		No	ClinGen gnomAD
rs1450779231 CA354425237	366	D>G		No	ClinGen TOPMed gnomAD
CA2600475 rs769295051	367	S>P		No	ClinGen ExAC gnomAD
rs776506560 CA2600473	369	T>N		No	ClinGen ExAC gnomAD
rs776506560 CA2600474	369	T>S		No	ClinGen ExAC gnomAD
rs746935098 CA2600471	373	I>F		No	ClinGen ExAC gnomAD
CA2600470 rs778036947	374	L>V		No	ClinGen ExAC gnomAD
CA354425168 rs1271605084	378	A>S		No	ClinGen gnomAD
CA82529791 rs748264239	380	N>K		No	ClinGen ExAC TOPMed gnomAD
CA354425134 rs1420210127	381	I>T		No	ClinGen TOPMed gnomAD
rs1413835598 CA354425136	381	I>V		No	ClinGen TOPMed gnomAD
CA82529760 rs867206557	383	I>V		No	ClinGen Ensembl
CA354425115 rs1169591268	384	D>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA2600447 rs749479360	386	P>H		No	ClinGen ExAC TOPMed gnomAD
CA82529743 rs749479360	386	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs768988335 CA2600448	386	P>S		No	ClinGen ExAC gnomAD
CA2600445 rs756491070	387	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1208194993 CA354425087	388	E>A		No	ClinGen gnomAD
CA2600444 rs149030563	391	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs41266495 CA2600443	391	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA354425055 rs1216857553	393	P>S		No	ClinGen gnomAD
rs1340415954 CA354425047	394	D>A		No	ClinGen gnomAD
rs1560020846 CA354425042	395	E>K		No	ClinGen Ensembl
CA354425030 rs1246213012	397	H>N		No	ClinGen gnomAD
rs757644183 CA2600442	398	Y>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1394881492 CA354424986	403	T>S		No	ClinGen gnomAD
TCGA novel	404	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA354424979 rs1330765882	404	F>S		No	ClinGen gnomAD
rs759305274 CA2600439	406	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs370929298 CA2600437	406	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs370929298 CA2600438	406	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA2600436 rs760579180	407	P>L		No	ClinGen ExAC TOPMed gnomAD
CA354424955 rs1445465553	408	V>E		No	ClinGen gnomAD
CA354424953 rs1387383761	409	I>V		No	ClinGen gnomAD
rs772061094 CA2600434	410	V>A		No	ClinGen ExAC gnomAD
CA2600433 rs761651988	411	A>D		No	ClinGen ExAC TOPMed gnomAD
CA354424940 rs761651988	411	A>G		No	ClinGen ExAC TOPMed gnomAD
rs751153290 CA354424942	411	A>P		No	ClinGen TOPMed
rs751153290 CA82529668	411	A>T		No	ClinGen TOPMed
rs1231883019 CA354424934	412	Y>C		No	ClinGen TOPMed
rs1576792335 CA354424929	413	K>E		No	ClinGen Ensembl
CA354424900 rs1482381551	417	V>L		No	ClinGen gnomAD
rs962830158 CA82529629	419	Q>E		No	ClinGen Ensembl
rs1017412178 CA82529622	419	Q>R		No	ClinGen Ensembl
CA354424880 rs1274359910	420	H>D		No	ClinGen gnomAD
CA354424863 rs1362056373	422	Q>R		No	ClinGen gnomAD
CA354424858 rs1227416065	423	D>N		No	ClinGen TOPMed gnomAD
CA354424856 rs1227416065	423	D>Y		No	ClinGen TOPMed gnomAD
CA2600430 rs749315908	424	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1161665586 CA354424826	426	V>I		No	ClinGen gnomAD
CA354424813 rs1455647705	427	H>Q		No	ClinGen gnomAD
CA354424803 COSM1659479 rs1177720373	429	T>A	kidney [Cosmic]	No	ClinGen cosmic curated gnomAD
CA2600410 rs770055133	429	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs910875883 CA82529370	431	N>K		No	ClinGen TOPMed
rs768893500 CA354424775 CA82529366	433	V>L		No	ClinGen TOPMed gnomAD
CA2600407 rs575084947	439	P>L		No	ClinGen 1000Genomes ExAC gnomAD
CA354424734 rs1204967052	439	P>S		No	ClinGen TOPMed
CA82529357 rs747182747	441	L>P		No	ClinGen TOPMed gnomAD
rs1225233244 CA354424722	442	V>L		No	ClinGen gnomAD
rs201493798 CA2600405	443	V>A		No	ClinGen ExAC TOPMed gnomAD
rs758909297 CA2600404	444	A>S		No	ClinGen ExAC gnomAD
rs547372193 CA82529333	444	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA2600402 rs779698096	447	Y>C		No	ClinGen ExAC gnomAD
CA2600399 TCGA novel rs377625300	450	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ESP ExAC TOPMed gnomAD
CA354424654 rs1468025896	452	T>I		No	ClinGen gnomAD
rs1126829 CA2600396	453	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1126829 CA2600397	453	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2600395 COSM72486 rs756937909	454	I>T	ovary [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA354424641 rs1392454767	455	I>N		No	ClinGen TOPMed gnomAD
CA354424640 rs1392454767	455	I>T		No	ClinGen TOPMed gnomAD
rs1186229975	455	I>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA2600394 rs775610495	456	Y>C		No	ClinGen ExAC gnomAD
CA2600391 rs201296544	458	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs200124017 CA2600392	458	R>W		No	ClinGen ExAC gnomAD
rs747341091 CA2600389	462	S>F		No	ClinGen ExAC gnomAD
rs773568912 CA2600388	464	T>S		No	ClinGen ExAC gnomAD
rs1016814885 CA82529236	465	K>Q		No	ClinGen TOPMed
RCV000885417 CA2600387 rs146757242	465	K>R		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1249460383 CA354424177	468	A>S		No	ClinGen gnomAD
TCGA novel	468	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1181375835 CA354424172	468	A>V		No	ClinGen gnomAD
CA354424170 rs1291797054	469	A>T		No	ClinGen gnomAD
TCGA novel	471	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2600359 rs758215760	476	A>P		No	ClinGen ExAC TOPMed gnomAD
rs778828673 CA2600356	481	Q>*		No	ClinGen ExAC gnomAD
rs753924591 CA2600354	484	T>S		No	ClinGen ExAC TOPMed gnomAD
rs1332018489 CA354423959	485	L>M		No	ClinGen gnomAD
CA354423932 rs1325992737	487	N>S		No	ClinGen gnomAD
TCGA novel	489	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766475655 CA354423892	490	I>K		No	ClinGen ExAC gnomAD
CA2600353 rs766475655	490	I>T		No	ClinGen ExAC gnomAD
rs1389640103 CA354423876	491	G>V		No	ClinGen gnomAD
TCGA novel	492	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA354423843 rs1576791034	494	R>C		No	ClinGen Ensembl
rs750695770 CA2600351	494	R>H		No	ClinGen ExAC TOPMed gnomAD
rs369349961 CA2600350	495	H>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA354423785 rs1158271671	497	D>H		No	ClinGen gnomAD
rs774796099 CA2600348	498	E>K		No	ClinGen ExAC gnomAD
rs769098992 CA2600347	500	V>I		No	ClinGen ExAC TOPMed gnomAD
CA2600346 rs142889882	501	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs770456695 CA2600344	504	K>E		No	ClinGen ExAC gnomAD
rs777437240 CA2600342	506	S>F		No	ClinGen ExAC TOPMed gnomAD
CA354423626 rs1231449821	507	R>Q		No	ClinGen gnomAD
rs771649293 CA2600341	507	R>W		No	ClinGen ExAC gnomAD
CA2600340 rs532769664	508	D>E		No	ClinGen 1000Genomes ExAC gnomAD
CA2600339 rs778668806	510	S>F		No	ClinGen ExAC gnomAD
rs754938131 CA2600338	511	T>I		No	ClinGen ExAC TOPMed gnomAD
rs754938131 CA354423566	511	T>S		No	ClinGen ExAC TOPMed gnomAD
CA2600337 rs753779504	513	N>S		No	ClinGen ExAC gnomAD
rs374967774 CA2600335	515	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA2600336 rs148503041	515	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs11550213 CA82525879	517	K>N		No	ClinGen Ensembl
rs200859227 CA2600334	517	K>R		No	ClinGen 1000Genomes ExAC gnomAD
CA2600333 rs767863573	518	S>I		No	ClinGen ExAC TOPMed gnomAD
CA2600332 rs762110508	521	T>S		No	ClinGen ExAC gnomAD
CA354423409 rs1402202526	523	H>R		No	ClinGen TOPMed
rs764483764 CA2600330	524	K>E		No	ClinGen ExAC gnomAD
CA2600328 rs201108570	525	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA2600329 rs201108570	525	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA2600326 rs760185472	526	L>F		No	ClinGen ExAC TOPMed gnomAD
CA2600327 rs765626173	526	L>S		No	ClinGen ExAC
CA354423377 rs1208253275	527	T>S		No	ClinGen gnomAD
CA2600324 rs771771865	530	I>T		No	ClinGen ExAC gnomAD
rs1560019598 CA354423339	533	L>P		No	ClinGen Ensembl
TCGA novel	535	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1298867468 CA354423320	536	R>T		No	ClinGen gnomAD
rs1353978304 CA354423304	538	K>N		No	ClinGen TOPMed
rs1230127021 CA354423291	540	E>D		No	ClinGen TOPMed gnomAD
CA2600323 rs747796049	541	G>S		No	ClinGen ExAC gnomAD
rs774054649 CA354423272	542	S>P		No	ClinGen ExAC gnomAD
CA2600322 rs774054649	542	S>T		No	ClinGen ExAC gnomAD
rs3182181 CA2600321	543	D>N		No	ClinGen ExAC gnomAD
CA2600320 rs748994971	544	L>R		No	ClinGen ExAC gnomAD
CA354423241 rs1360417514	544	L>V		No	ClinGen gnomAD
CA354423207 rs1370903232	547	R>K		No	ClinGen gnomAD
rs552090023 CA2600295	548	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs747024275 CA2600294	549	S>C		No	ClinGen ExAC TOPMed gnomAD
CA354422856 rs1287117362	551	M>V		No	ClinGen gnomAD
rs913169616 CA354422805	558	V>I		No	ClinGen TOPMed gnomAD
rs913169616 CA82524187	558	V>L		No	ClinGen TOPMed gnomAD
rs765517331 CA2600290	565	S>L		No	ClinGen ExAC TOPMed gnomAD
CA354422755 rs1437455213	566	A>T		No	ClinGen gnomAD
CA2600288 COSM1418774 rs754321104	566	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs750975502 CA2600286	570	E>D		No	ClinGen ExAC TOPMed gnomAD
rs763863363 CA2600284	571	R>C		No	ClinGen ExAC gnomAD
rs762506765 CA2600283	571	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1051789213 CA82524121	575	G>S		No	ClinGen TOPMed
CA2600281 rs769684829	577	L>P		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	578	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1000831554 CA82524092	581	T>M		No	ClinGen TOPMed gnomAD
rs770929459 CA2600278	583	I>T		No	ClinGen ExAC gnomAD
rs776743768 CA2600279	583	I>V		No	ClinGen ExAC TOPMed gnomAD
CA2600277 rs747128020	587	K>N		No	ClinGen ExAC gnomAD
CA2600276 rs777703913	592	K>E		No	ClinGen ExAC gnomAD
CA82524061 rs538846683	593	R>C		No	ClinGen gnomAD
COSM1670549 rs1291949937 CA354422577	593	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA354422549 rs1389428034	597	V>A		No	ClinGen TOPMed gnomAD
CA354422527 rs142951968	600	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs779299093 CA2600273	601	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1363669516 CA354422518	602	H>D		No	ClinGen TOPMed gnomAD
CA2600272 rs755358786	602	H>Q		No	ClinGen ExAC gnomAD
rs1363669516 CA354422517	602	H>Y		No	ClinGen TOPMed gnomAD
rs1386629202 CA354422509	603	I>S		No	ClinGen TOPMed
rs1429135539 CA354422498	605	D>A		No	ClinGen gnomAD
CA2600271 rs754134712	605	D>Y		No	ClinGen ExAC gnomAD
rs1423535502 CA354422493	606	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs780552430 CA2600270	606	A>V		No	ClinGen ExAC gnomAD

No associated diseases with P04843

No regional properties for P04843

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P04843

Functions

		Description
EC Number
Subcellular Localization	Endoplasmic reticulum Endoplasmic reticulum membrane; Single-pass type I membrane protein Melanosome	Identified by mass spectrometry in melanosome fractions from stage I to stage IV
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

8 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
melanosome	A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
oligosaccharyltransferase complex	A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected.
rough endoplasmic reticulum	The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.

1 GO annotations of molecular function

Name	Definition
RNA binding	Binding to an RNA molecule or a portion thereof.

3 GO annotations of biological process

Name	Definition
protein modification process	The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
protein N-linked glycosylation	A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan.
protein N-linked glycosylation via asparagine	The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification.

5 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q91YQ5	Rpn1	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	Mus musculus (Mouse)	PR
Q6PIX5	Rhbdf1	Inactive rhomboid protein 1	Mus musculus (Mouse)	PR
Q9GMB0	RPN1	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	Sus scrofa (Pig)	PR
P07153	Rpn1	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	Rattus norvegicus (Rat)	PR
Q0DJC5	OST1A	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A	Oryza sativa subsp japonica (Rice)	PR

10	20	30	40	50	60
MEAPAAGLFL	LLLLGTWAPA	PGSASSEAPP	LINEDVKRTV	DLSSHLAKVT	AEVVLAHLGG
70	80	90	100	110	120
GSTSRATSFL	LALEPELEAR	LAHLGVQVKG	EDEEENNLEV	RETKIKGKSG	RFFTVKLPVA
130	140	150	160	170	180
LDPGAKISVI	VETVYTHVLH	PYPTQITQSE	KQFVVFEGNH	YFYSPYPTKT	QTMRVKLASR
190	200	210	220	230	240
NVESYTKLGN	PTRSEDLLDY	GPFRDVPAYS	QDTFKVHYEN	NSPFLTITSM	TRVIEVSHWG
250	260	270	280	290	300
NIAVEENVDL	KHTGAVLKGP	FSRYDYQRQP	DSGISSIRSF	KTILPAAAQD	VYYRDEIGNV
310	320	330	340	350	360
STSHLLILDD	SVEMEIRPRF	PLFGGWKTHY	IVGYNLPSYE	YLYNLGDQYA	LKMRFVDHVF
370	380	390	400	410	420
DEQVIDSLTV	KIILPEGAKN	IEIDSPYEIS	RAPDELHYTY	LDTFGRPVIV	AYKKNLVEQH
430	440	450	460	470	480
IQDIVVHYTF	NKVLMLQEPL	LVVAAFYILF	FTVIIYVRLD	FSITKDPAAE	ARMKVACITE
490	500	510	520	530	540
QVLTLVNKRI	GLYRHFDETV	NRYKQSRDIS	TLNSGKKSLE	TEHKALTSEI	ALLQSRLKTE
550	560	570	580	590	600
GSDLCDRVSE	MQKLDAQVKE	LVLKSAVEAE	RLVAGKLKKD	TYIENEKLIS	GKRQELVTKI

DHILDAL