AiPD: Autoinhibited Protein Database

Gene name	Gpr108 (Lustr2)
Protein name	Protein GPR108
Names	Lung seven transmembrane receptor 2
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:78308
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

114-243 (Predicted disordered autoinhibitory region) PR

114-243 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q91WD0-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389441612	2	A>V	No	EVA
rs3389386472	10	S>R	No	EVA
rs3389478110	12	E>*	No	EVA
rs3389468234	13	S>R	No	EVA
rs226301519	80	L>F	No	EVA
rs3389478031	104	H>Y	No	EVA
rs3389476917	126	L>M	No	EVA
rs108333746	150	T>S	No	EVA
rs3407887726	174	T>SL*	No	EVA
rs3389441628	179	V>I	No	EVA
rs3389468897	183	Q>H	No	EVA
rs213470309	197	E>G	No	EVA
rs3389468940	199	R>G	No	EVA
rs3389423594	210	D>E	No	EVA
rs244352926	218	Q>L	No	EVA
rs52767493	246	Y>C	No	EVA
rs52767492	250	F>L	No	EVA
rs52767491	254	H>D	No	EVA
rs258390509	254	H>R	No	EVA
rs52767490	256	S>C	No	EVA
rs236677283	295	A>V	No	EVA
rs3389466770	312	T>I	No	EVA
rs3389491165	347	G>C	No	EVA
rs3389476955	363	L>V	No	EVA
rs3389423545	371	T>S	No	EVA
rs3389478094	404	A>D	No	EVA
rs3389386505	444	V>I	No	EVA
rs3389454239	500	Q>*	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q91WD0

		Description
EC Number
Subcellular Localization	Golgi apparatus, cis-Golgi network membrane ; Multi-pass membrane protein Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein Golgi apparatus membrane; Multi-pass membrane protein	Colocalizes with TLR3, -7, -4, and -9
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cis-Golgi network membrane	The lipid bilayer surrounding any of the compartments that make up the cis-Golgi network.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
trans-Golgi network	The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.

Name	Definition
No GO annotations for molecular function

Name	Definition
negative regulation of toll-like receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway.
regulation of immune response	Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8BXN9	Tmem87a	Transmembrane protein 87A	Mus musculus (Mouse)	PR
Q8BKU8	Tmem87b	Transmembrane protein 87B	Mus musculus (Mouse)	PR
Q6P6V6	Gpr108	Protein GPR108	Rattus norvegicus (Rat)	PR