AiPD: Autoinhibited Protein Database

Q8WTX7

Gene name	CASTOR1
Protein name	Cytosolic arginine sensor for mTORC1 subunit 1
Names	Cellular arginine sensor for mTORC1 protein 1, GATS-like protein 3
Species	Homo sapiens (Human)
KEGG Pathway	hsa:652968
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

125-205 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

125-205 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

6 structures for Q8WTX7

Entry ID	Method	Resolution	Chain	Position	Source
5GS9	X-ray	250 A	A/B/C/D	1-329	PDB
5GT7	X-ray	205 A	A/B/C/D	1-323	PDB
5GT8	X-ray	280 A	A/B/C/D	1-329	PDB
5GV2	X-ray	206 A	A/C	1-329	PDB
5I2C	X-ray	180 A	A/B/C/D	1-329	PDB
AF-Q8WTX7-F1	Predicted				AlphaFoldDB

256 variants for Q8WTX7

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA323200936 rs950853836	2	E>D		No	ClinGen TOPMed gnomAD
CA411177740 rs1360258670	2	E>G		No	ClinGen TOPMed gnomAD
CA411177714 rs1474258437	6	L>P		No	ClinGen gnomAD
rs1188529312 CA411177710	7	E>Q		No	ClinGen gnomAD
rs766685244 CA10179088	9	R>Q		No	ClinGen ExAC gnomAD
CA323200926 rs976479578	9	R>W		No	ClinGen TOPMed
CA411177692 rs1281818781	10	V>L		No	ClinGen TOPMed gnomAD
rs1230990140 CA411177662	15	V>L		No	ClinGen gnomAD
CA411177645 rs1295701205	17	R>H		No	ClinGen gnomAD
rs1312451801 CA411177635	19	G>D		No	ClinGen TOPMed
CA411177638 rs1482107841	19	G>S		No	ClinGen Ensembl
rs1312451801 CA411177633	19	G>V		No	ClinGen TOPMed
rs748754620 CA10179084	20	L>I		No	ClinGen ExAC gnomAD
CA10179083 rs774552859	22	L>P		No	ClinGen ExAC gnomAD
rs1569156943 CA411177602	24	T>I		No	ClinGen Ensembl
rs1569156943 CA411177600	24	T>N		No	ClinGen Ensembl
rs1162884607 CA411177605	24	T>P		No	ClinGen gnomAD
CA10179080 rs749482647	25	H>N		No	ClinGen ExAC gnomAD
CA10179079 rs780446646	25	H>P		No	ClinGen ExAC gnomAD
rs778325860 CA323200810	31	L>F		No	ClinGen gnomAD
CA411177549 rs1211407051	32	F>L		No	ClinGen TOPMed gnomAD
rs758257661 CA10179075	33	L>P		No	ClinGen ExAC gnomAD
rs200243403 CA10179074	35	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA323200805 rs1006825804	35	R>H		No	ClinGen TOPMed
CA411177531 rs1339226315	36	R>C		No	ClinGen gnomAD
rs1268802966 CA411177530	36	R>H		No	ClinGen gnomAD
rs754511179 CA10179073	38	R>G		No	ClinGen ExAC gnomAD
CA10179037 rs771802454	40	K>Q		No	ClinGen ExAC gnomAD
CA10179036 rs369487022	42	F>L		No	ClinGen ESP ExAC gnomAD
rs1157938319 CA411177457	45	T>K		No	ClinGen gnomAD
CA411177446 rs1390763350	47	T>A		No	ClinGen gnomAD
CA411177425 rs1409535737	50	D>H		No	ClinGen gnomAD
CA411177426 rs1409535737	50	D>N		No	ClinGen gnomAD
rs1177218483 CA411177416	51	Y>D		No	ClinGen gnomAD
rs201324550 CA10179034	52	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA411177406 rs201324550	52	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs749279564 CA10179033	55	V>G		No	ClinGen ExAC gnomAD
CA411177384 rs1186390910	56	D>N		No	ClinGen gnomAD
rs1013339327 CA323200047	58	E>K		No	ClinGen TOPMed
rs779407828 CA10179032	59	G>S		No	ClinGen ExAC gnomAD
rs1315287825 CA411177352	60	F>S		No	ClinGen gnomAD
TCGA novel	61	K>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1249848238 CA411177042	65	P>L		No	ClinGen gnomAD
rs1275107996 CA411176938	74	A>S		No	ClinGen gnomAD
rs753947047 CA10179002	75	T>P		No	ClinGen ExAC gnomAD
CA10179000 rs760863995	78	V>G		No	ClinGen ExAC gnomAD
rs1310256562 CA411176876	80	N>I		No	ClinGen TOPMed
rs370157427 CA10178996	81	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs370157427 CA10178997	81	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs769766060 CA10178995	82	S>L		No	ClinGen ExAC gnomAD
rs1309168422 CA411176816	84	H>Y		No	ClinGen TOPMed gnomAD
rs1470134696 CA411176768	86	G>D		No	ClinGen gnomAD
CA411176778 rs770608537	86	G>R		No	ClinGen ExAC TOPMed gnomAD
rs770608537 CA10178992	86	G>S		No	ClinGen ExAC TOPMed gnomAD
rs189381704 COSM1033249 CA10178991	87	A>V	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs569590873 CA10178989	88	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA411176715 rs748546063	89	V>A		No	ClinGen ExAC TOPMed gnomAD
CA10178988 rs748546063	89	V>G		No	ClinGen ExAC TOPMed gnomAD
CA323198505 rs1049003084	89	V>M		No	ClinGen TOPMed gnomAD
CA10178987 rs779207814	90	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA10178986 rs755496950	91	A>P		No	ClinGen ExAC
rs557296879 CA10178985	92	A>T		No	ClinGen ExAC gnomAD
CA323198470 rs547890105	94	V>G		No	ClinGen 1000Genomes
rs780075887 CA10178984	94	V>L		No	ClinGen ExAC gnomAD
CA411176613 rs1410320520	95	T>A		No	ClinGen TOPMed
rs2240421 CA323198463	97	I>S		No	ClinGen Ensembl
CA10178982 rs750588499	98	A>S		No	ClinGen ExAC gnomAD
rs750588499 CA411176549	98	A>T		No	ClinGen ExAC gnomAD
rs767731570 CA10178981	98	A>V		No	ClinGen ExAC gnomAD
rs201164151 CA10178980	99	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA323198422 rs368955430	99	R>H		No	ClinGen ESP TOPMed gnomAD
CA323198419 rs368955430	99	R>P		No	ClinGen ESP TOPMed gnomAD
rs1316953731 CA411176499	100	S>L		No	ClinGen TOPMed gnomAD
rs1353991023 CA411176478	103	A>T		No	ClinGen TOPMed gnomAD
rs759489489 CA10178977 COSM1033248	103	A>V	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA411176399 rs1192175247	107	E>G		No	ClinGen TOPMed
CA10178973 rs772929352	107	E>K		No	ClinGen ExAC
CA411176355 rs749410812	109	H>D		No	ClinGen ExAC TOPMed gnomAD
CA10178972 rs749410812	109	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs747812777 CA10178971	110	V>L		No	ClinGen ExAC gnomAD
rs1431724078 CA411176227	116	S>C		No	ClinGen TOPMed
rs768939653 CA10178969	120	T>M		No	ClinGen ExAC TOPMed gnomAD
CA323198339 rs1020524089	121	D>Y		No	ClinGen TOPMed
rs1259280906 CA411176109	123	I>V		No	ClinGen gnomAD
rs200867191 CA411176026	125	V>L		No	ClinGen gnomAD
rs200867191 CA323198149	125	V>M		No	ClinGen gnomAD
rs771531140 CA10178955	126	R>Q		No	ClinGen ExAC gnomAD
rs1463830300 CA411176014	126	R>W		No	ClinGen TOPMed
rs1188106939 CA411175994	127	E>G		No	ClinGen TOPMed
rs1569156333 CA411176005	127	E>K		No	ClinGen Ensembl
CA411175981 rs1174789024	128	Q>E		No	ClinGen TOPMed gnomAD
CA411175909 rs773905426	132	V>L		No	ClinGen ExAC TOPMed gnomAD
CA10178953 rs773905426	132	V>M		No	ClinGen ExAC TOPMed gnomAD
CA411175873 rs1438851474	134	I>T		No	ClinGen gnomAD
CA10178952 rs749659130	136	T>K		No	ClinGen ExAC TOPMed gnomAD
rs749659130 CA10178951	136	T>M		No	ClinGen ExAC TOPMed gnomAD
rs775900727 CA10178950	139	Q>*		No	ClinGen ExAC gnomAD
rs1020417456 CA323198107	140	E>K		No	ClinGen TOPMed
CA10178949 rs770273699	141	F>C		No	ClinGen ExAC gnomAD
rs1394074674 CA411175775	141	F>L		No	ClinGen gnomAD
rs543656811 CA10178948	141	F>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs757314887 CA10178946	142	D>N		No	ClinGen ExAC TOPMed gnomAD
CA411175739 rs1191330397	143	I>V		No	ClinGen gnomAD
CA10178945 rs777867470	145	R>C		No	ClinGen ExAC gnomAD
CA10178944 rs777867470	145	R>G		No	ClinGen ExAC gnomAD
rs754751394 CA10178943	145	R>H		No	ClinGen ExAC TOPMed gnomAD
rs754751394 CA411175696	145	R>L		No	ClinGen ExAC TOPMed gnomAD
rs1437696372 CA411175691	146	E>K		No	ClinGen gnomAD
CA411175640 rs1207815922	149	G>R		No	ClinGen gnomAD
CA411175613 rs201329349	150	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA411175591 rs1279940779	152	V>L		No	ClinGen gnomAD
rs1442753585 CA411175570	153	P>L		No	ClinGen gnomAD
CA10178939 rs750425901	154	V>L		No	ClinGen ExAC gnomAD
CA411175567 rs750425901	154	V>M		No	ClinGen ExAC gnomAD
CA10178938 rs767011073	155	T>M		No	ClinGen ExAC TOPMed gnomAD
CA411175541 rs767011073	155	T>R		No	ClinGen ExAC TOPMed gnomAD
CA323198058 rs931347611	156	R>K		No	ClinGen Ensembl
rs931347611 CA411175527	156	R>T		No	ClinGen Ensembl
CA411175437 rs1441408019	161	N>S		No	ClinGen TOPMed gnomAD
CA411175427 rs1309773541	162	G>D		No	ClinGen gnomAD
rs1333967389 CA411175430	162	G>S		No	ClinGen gnomAD
rs373119268 CA10178936	164	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1374604665 CA411175401	164	P>L		No	ClinGen TOPMed gnomAD
rs373119268 CA411175407	164	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs762652275 CA10178935	165	R>C		No	ClinGen ExAC TOPMed gnomAD
rs200418035 CA10178933	165	R>H		No	ClinGen ExAC TOPMed gnomAD
rs762652275 CA10178934	165	R>S		No	ClinGen ExAC TOPMed gnomAD
rs770187963 CA10178932	166	T>A		No	ClinGen ExAC gnomAD
CA411175374 rs1473170002	167	Q>H		No	ClinGen TOPMed
rs1040070755 CA323198013	168	H>R		No	ClinGen TOPMed gnomAD
CA10178893 rs761053103	171	S>C		No	ClinGen ExAC TOPMed gnomAD
rs1453892920 CA411175277	173	T>A		No	ClinGen gnomAD
CA411175272 rs773797881	173	T>M		No	ClinGen ExAC TOPMed gnomAD
CA10178892 rs773797881	173	T>R		No	ClinGen ExAC TOPMed gnomAD
rs748179483 CA323197510	177	I>F		No	ClinGen Ensembl
rs761997957 CA10178890	179	S>N		No	ClinGen ExAC TOPMed gnomAD
CA10178888 rs768987098	181	Q>H		No	ClinGen ExAC gnomAD
rs373540448 CA10178887	183	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA10178886 rs780821080	183	R>H		No	ClinGen ExAC gnomAD
rs1233050254 CA411175158	184	F>C		No	ClinGen gnomAD
CA10178885 rs770794054	184	F>V		No	ClinGen ExAC TOPMed gnomAD
CA10178884 rs746875088	187	L>F		No	ClinGen ExAC gnomAD
rs777705383 CA10178883	187	L>P		No	ClinGen ExAC TOPMed gnomAD
CA10178880 rs778448281	189	L>M		No	ClinGen ExAC gnomAD
CA10178881 rs778448281	189	L>V		No	ClinGen ExAC gnomAD
CA10178879 rs143253536	190	D>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10178878 rs753564212	191	P>A		No	ClinGen ExAC gnomAD
rs1295692676 CA411175072	193	T>A		No	ClinGen TOPMed
CA10178877 rs201464855	193	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201464855 CA411175067	193	T>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs750902277 CA10178875	195	P>R		No	ClinGen ExAC gnomAD
rs377132305 CA10178873	196	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs764277009 CA10178870	203	D>E		No	ClinGen ExAC gnomAD
CA10178868 rs775807200	208	S>L		No	ClinGen ExAC TOPMed gnomAD
rs749592222 CA411173890	210	S>R		No	ClinGen ExAC gnomAD
rs758898589 CA411173869	211	T>I		No	ClinGen ExAC TOPMed gnomAD
CA10178833 rs758898589	211	T>N		No	ClinGen ExAC TOPMed gnomAD
rs1601662064 CA411173881	211	T>P		No	ClinGen Ensembl
rs758898589 CA10178832	211	T>S		No	ClinGen ExAC TOPMed gnomAD
CA10178831 rs765279131	212	P>L		No	ClinGen ExAC TOPMed gnomAD
rs765279131 CA10178830	212	P>R		No	ClinGen ExAC TOPMed gnomAD
CA411173801 rs1341863741	216	A>G		No	ClinGen TOPMed gnomAD
rs1210884083 CA411173804	216	A>S		No	ClinGen gnomAD
CA411173800 rs1341863741	216	A>V		No	ClinGen TOPMed gnomAD
CA411173790 rs1437256728	217	S>C		No	ClinGen gnomAD
CA411173780 rs1442631054	218	S>T		No	ClinGen TOPMed
CA10178829 rs759719627	222	P>H		No	ClinGen ExAC gnomAD
CA411173724 rs1601662024	223	S>T		No	ClinGen Ensembl
rs367889379 CA323196860	224	S>C		No	ClinGen ESP TOPMed gnomAD
CA10178827 rs767247380	225	I>V		No	ClinGen ExAC gnomAD
CA10178825 rs374308991	226	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA10178826 rs374308991	226	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA411173652 rs1423795354	229	A>V		No	ClinGen gnomAD
rs962847535 CA323196772	234	E>K		No	ClinGen gnomAD
CA411173591 rs1207279332	235	G>D		No	ClinGen TOPMed
rs781008682 CA10178818	235	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1380618335 CA411173561	238	S>T		No	ClinGen gnomAD
CA10178817 rs771356842	241	M>L		No	ClinGen ExAC gnomAD
rs771356842 CA411173533	241	M>V		No	ClinGen ExAC gnomAD
CA411173512 rs1488366965	242	D>E		No	ClinGen TOPMed
rs1194487545 CA411173484	245	T>I		No	ClinGen TOPMed
CA411173482 rs1200177907	246	Q>K		No	ClinGen gnomAD
rs747378262 CA10178816	246	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA411173458 rs1417314313	248	K>E		No	ClinGen gnomAD
CA323196506 rs547927578	248	K>N		No	ClinGen gnomAD
rs1188058299 CA411173454	248	K>R		No	ClinGen TOPMed
CA411173399 rs1161986616	250	P>S		No	ClinGen TOPMed gnomAD
rs1473131737 CA411173371	252	D>E		No	ClinGen gnomAD
rs769966102 CA323196505	253	L>F		No	ClinGen Ensembl
CA10178794 rs748636183	257	S>N		No	ClinGen ExAC gnomAD
CA10178793 rs754982494	259	S>L		No	ClinGen ExAC TOPMed gnomAD
CA10178792 rs754982494	259	S>W		No	ClinGen ExAC TOPMed gnomAD
CA323196443 rs1000404870	260	G>R		No	ClinGen Ensembl
rs1209213155 CA411173258	264	R>K		No	ClinGen TOPMed gnomAD
rs1320890498 CA411173246	265	M>L		No	ClinGen gnomAD
CA411173232 rs780165118	266	V>L		No	ClinGen ExAC TOPMed gnomAD
CA10178790 rs780165118	266	V>M		No	ClinGen ExAC TOPMed gnomAD
rs756306909 CA10178789 COSM1415696	267	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1296415462 CA411173222	267	R>H		No	ClinGen gnomAD
rs1432335189 CA411173215	268	I>V		No	ClinGen gnomAD
rs572104208 CA323196363	269	G>D		No	ClinGen 1000Genomes
rs750642300 CA10178788	269	G>S		No	ClinGen ExAC gnomAD
rs1454725830 CA411173198	270	G>R		No	ClinGen gnomAD
CA411173184 rs1241611854	271	Q>L		No	ClinGen TOPMed gnomAD
rs1021389156 CA323196354	272	P>L		No	ClinGen TOPMed
rs1301568715 CA411173174	272	P>S		No	ClinGen TOPMed
CA323196196 rs757768327	276	D>E		No	ClinGen TOPMed gnomAD
CA323196322 rs370649027	276	D>N		No	ClinGen ESP
rs765176150 CA10178766	279	G>A		No	ClinGen ExAC gnomAD
CA411173020 rs1299868352	283	Q>E		No	ClinGen gnomAD
CA10178765 rs754938761	286	G>D		No	ClinGen ExAC gnomAD
CA411172980 rs1221366822	286	G>S		No	ClinGen gnomAD
rs753853345 CA10178764	287	P>S		No	ClinGen ExAC gnomAD
CA411172965 rs1408359730	288	L>M		No	ClinGen gnomAD
CA411172952 rs1601661600	289	A>P		No	ClinGen Ensembl
CA10178760 rs767070750	291	A>T		No	ClinGen ExAC TOPMed gnomAD
CA411172873 rs1178178888	294	S>F		No	ClinGen gnomAD
CA10178758 rs774675821	298	I>F		No	ClinGen ExAC gnomAD
CA10178757 rs769048839	299	S>N		No	ClinGen ExAC gnomAD
CA411172802 rs749746879	299	S>R		No	ClinGen ExAC gnomAD
rs775990870 CA10178755	300	T>I		No	ClinGen ExAC TOPMed gnomAD
CA10178754 rs769847466	304	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1257198960 CA411172754	304	D>N		No	ClinGen gnomAD
CA323196105 rs954554338	305	H>L		No	ClinGen TOPMed
rs745933272 CA10178753	305	H>Q		No	ClinGen ExAC gnomAD
CA411172735 rs1324939715	305	H>Y		No	ClinGen gnomAD
CA10178751 rs757402615	306	A>D		No	ClinGen ExAC TOPMed gnomAD
rs757402615 CA10178750	306	A>G		No	ClinGen ExAC TOPMed gnomAD
rs1211488559 CA411172721	306	A>T		No	ClinGen TOPMed
rs778807317 CA10178748	307	L>M		No	ClinGen ExAC gnomAD
rs867318734 CA323196033	307	L>R		No	ClinGen Ensembl
rs201496296 CA10178746	307	L>R		No	ClinGen TOPMed
rs1222969937 CA411172633	310	E>K		No	ClinGen TOPMed gnomAD
CA323195796 rs747175965	311	D>E		No	ClinGen ExAC TOPMed
rs771078179 CA10178720	311	D>N		No	ClinGen ExAC TOPMed gnomAD
rs778151331 CA10178717	312	G>S		No	ClinGen ExAC gnomAD
CA411172593 rs768496780	313	I>M		No	ClinGen ExAC TOPMed gnomAD
CA411172589 rs1209687271	314	G>D		No	ClinGen gnomAD
rs1263006101 CA411172592	314	G>S		No	ClinGen TOPMed gnomAD
rs1294233274 CA411172583	315	S>N		No	ClinGen gnomAD
rs574213079 CA10178714	316	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA411172573 rs1419069530	317	I>V		No	ClinGen TOPMed
CA10178713 rs201767342	318	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA10178712 rs201767342	318	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs555778486 CA10178710	322	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs780527236 CA10178711	322	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1303416764 CA411172499	323	R>Q		No	ClinGen TOPMed gnomAD
rs891279022 CA323195743	323	R>W		No	ClinGen TOPMed gnomAD
CA411172477 rs1387912768	325	E>Q		No	ClinGen TOPMed gnomAD
rs751146629 CA10178709	326	G>D		No	ClinGen ExAC gnomAD
rs1234685598 CA411172461	326	G>S		No	ClinGen TOPMed
CA323195716 rs1051961531	327	L>P		No	ClinGen TOPMed
rs763733871 CA323195713	328	A>D		No	ClinGen ExAC TOPMed gnomAD
rs763733871 CA10178708	328	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1263248292 CA411172418	330	S>R		No	ClinGen TOPMed
rs867132814 CA323195694	330	S>W		No	ClinGen Ensembl

No associated diseases with Q8WTX7

3 regional properties for Q8WTX7

Type	Name	Position	InterPro Accession
domain	CASTOR, ACT domain	72 - 138	IPR027795-1
domain	CASTOR, ACT domain	259 - 321	IPR027795-2
domain	CASTOR1, N-terminal	9 - 69	IPR040778

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name	Definition
arginine binding	Binding to 2-amino-5-(carbamimidamido)pentanoic acid.
identical protein binding	Binding to an identical protein or proteins.
protein sequestering activity	Binding to a protein to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.

3 GO annotations of biological process

Name	Definition
cellular response to L-arginine	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus.
negative regulation of TORC1 signaling	Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling.
regulation of intracellular signal transduction	Any process that modulates the frequency, rate or extent of intracellular signal transduction.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q0V8A3	CASTOR1	Cytosolic arginine sensor for mTORC1 subunit 1	Bos taurus (Bovine)	PR
Q9CWQ8	Castor1	Cytosolic arginine sensor for mTORC1 subunit 1	Mus musculus (Mouse)	PR
Q5BJZ0	Castor1	Cytosolic arginine sensor for mTORC1 subunit 1	Rattus norvegicus (Rat)	PR
Q63ZZ8	castor2	Cytosolic arginine sensor for mTORC1 subunit 2	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MELHILEHRV	RVLSVARPGL	WLYTHPLIKL	LFLPRRSRCK	FFSLTETPED	YTLMVDEEGF
70	80	90	100	110	120
KELPPSEFLQ	VAEATWLVLN	VSSHSGAAVQ	AAGVTKIARS	VIAPLAEHHV	SVLMLSTYQT
130	140	150	160	170	180
DFILVREQDL	SVVIHTLAQE	FDIYREVGGE	PVPVTRDDSS	NGFPRTQHGP	SPTVHPIQSP
190	200	210	220	230	240
QNRFCVLTLD	PETLPAIATT	LIDVLFYSHS	TPKEAASSSP	EPSSITFFAF	SLIEGYISIV
250	260	270	280	290	300
MDAETQKKFP	SDLLLTSSSG	ELWRMVRIGG	QPLGFDECGI	VAQIAGPLAA	ADISAYYIST
310	320
FNFDHALVPE	DGIGSVIEVL	QRRQEGLAS