Q0V8A3

PR
Gene name
CASTOR1
Protein name
Cytosolic arginine sensor for mTORC1 subunit 1
Names
GATS-like protein 3
Species
Bos taurus (Bovine)
KEGG Pathway
bta:506974
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

125-250 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0V8A3

Entry ID Method Resolution Chain Position Source
AF-Q0V8A3-F1 Predicted AlphaFoldDB

82 variants for Q0V8A3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs446440316 28 I>T No EVA
rs479718184 29 K>R No EVA
rs448957880 31 L>F No EVA
rs482085164 32 F>S No EVA
rs463586894 33 L>V No EVA
rs438904152 35 R>G No EVA
rs433354722 39 C>S No EVA
rs471282961 39 C>W No EVA
rs453001364 40 K>M No EVA
rs434515316 40 K>N No EVA
rs437081840 42 F>S No EVA
rs448832949 42 F>V No EVA
rs470084534 43 S>G No EVA
rs445000150 44 L>M No EVA
rs478017108 45 T>P No EVA
rs466188360 47 T>A No EVA
rs466188360 47 T>P No EVA
rs447736270 48 P>S No EVA
rs447736270 48 P>T No EVA
rs480803756 49 E>A No EVA
rs462150581 50 D>E No EVA
rs443608458 51 Y>S No EVA
rs458298485 53 L>F No EVA
rs458298485 53 L>V No EVA
rs439730466 54 M>L No EVA
rs472592399 55 V>G No EVA
rs440890961 57 E>A No EVA
rs454274767 57 E>K No EVA
rs473947085 58 E>* No EVA
rs455287212 58 E>G No EVA
rs436794921 61 K>I No EVA
rs797748227 92 A>S No EVA
rs1117826722 107 E>Q No EVA
rs461475926 130 L>R No EVA
rs475775805 133 V>G No EVA
rs457374310 147 V>G No EVA
rs472134855 150 E>D No EVA
rs432633725 150 E>G No EVA
rs453387405 151 P>A No EVA
rs466589504 153 P>A No EVA
rs436082198 156 R>W No EVA
rs468804616 159 S>C No EVA
rs477069779 163 F>V No EVA
rs458852528 163 F>Y No EVA
rs446579912 168 H>N No EVA
rs463873095 190 D>A No EVA
rs466250558 210 S>R No EVA
rs435681602 214 E>D No EVA
rs437089708 215 A>T No EVA
rs468397695 221 G>* No EVA
rs450002668 221 G>A No EVA
rs458398902 223 S>I No EVA
rs479233324 228 F>L No EVA
rs460779796 241 M>R No EVA
rs440937287 244 E>K No EVA
rs461702972 247 K>E No EVA
rs3423443910 247 K>R No EVA
rs470094435 249 F>I No EVA
rs467295044 252 D>A No EVA
rs467295044 252 D>G No EVA
rs434237199 252 D>Y No EVA
rs448673846 257 S>I No EVA
rs481633456 259 S>A No EVA
rs469612341 261 E>K No EVA
rs136932452 263 W>G No EVA
rs482817459 271 Q>H No EVA
rs457622341 272 P>A No EVA
rs439188628 273 L>M No EVA
rs478920715 273 L>P No EVA
rs460291163 274 G>C No EVA
rs441900238 275 F>V No EVA
rs437637652 284 I>L No EVA
rs464284148 285 A>T No EVA
rs445555913 285 A>V No EVA
rs460002379 286 G>C No EVA
rs462540891 295 A>D No EVA
rs481158988 295 A>S No EVA
rs444224649 296 Y>* No EVA
rs136199242 316 V>G No EVA
rs473372985 319 V>A No EVA
rs134815090 320 L>P No EVA
rs454970610 321 Q>P No EVA

No associated diseases with Q0V8A3

3 regional properties for Q0V8A3

Type Name Position InterPro Accession
domain CASTOR, ACT domain 72 - 138 IPR027795-1
domain CASTOR, ACT domain 259 - 321 IPR027795-2
domain CASTOR1, N-terminal 9 - 69 IPR040778

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GATOR2 complex A multiprotein subcomplex of the GATOR complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, this complex consists of WDR24, WDR59, MIOS, SEH1L, and SEC13. In S. cerevisiae, this complex is referred to as SEACAT and contains the Sea2p, Sea3p, Sea4p, Seh1p, Sec13p proteins.

3 GO annotations of molecular function

Name Definition
arginine binding Binding to 2-amino-5-(carbamimidamido)pentanoic acid.
identical protein binding Binding to an identical protein or proteins.
protein sequestering activity Binding to a protein to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.

3 GO annotations of biological process

Name Definition
cellular response to L-arginine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus.
negative regulation of TORC1 signaling Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling.
regulation of intracellular signal transduction Any process that modulates the frequency, rate or extent of intracellular signal transduction.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8WTX7 CASTOR1 Cytosolic arginine sensor for mTORC1 subunit 1 Homo sapiens (Human) PR
Q9CWQ8 Castor1 Cytosolic arginine sensor for mTORC1 subunit 1 Mus musculus (Mouse) PR
Q5BJZ0 Castor1 Cytosolic arginine sensor for mTORC1 subunit 1 Rattus norvegicus (Rat) PR
Q63ZZ8 castor2 Cytosolic arginine sensor for mTORC1 subunit 2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MELHILEHRV RVLSLARPGL WLYTHPLIKL LFLPRRSRCK FFSLTETPED YTLMVDEEGF
70 80 90 100 110 120
KELPPSEFLQ VAEATWLVLN VSSPSGAAVQ AAGVTKIARS VIAPLAEHHV SVLMLSTYQT
130 140 150 160 170 180
DFILVREQDL SVVIHTLARE FDIYREVGGE PVPVARDDSS NGFPRAQHGP SPTVHPIQSP
190 200 210 220 230 240
QNRFCVLTLD PETLPAIATT LIDVLFYSHS PPREAASGGP GSSSIAFFAF SLIEGYISIV
250 260 270 280 290 300
MDAETQKKFP SDLLLTSSSG ELWRMVRIGG QPLGFDECGI VAQIAGPLAA ADISAYYIST
310 320
FNFDHALVPE DGIGSVIEVL QRRQDGLGS