Q5BJZ0
Gene name |
Castor1 |
Protein name |
Cytosolic arginine sensor for mTORC1 subunit 1 |
Names |
GATS-like protein 3 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:360969 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5BJZ0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5BJZ0-F1 | Predicted | AlphaFoldDB |
No variants for Q5BJZ0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5BJZ0 | |||||
No associated diseases with Q5BJZ0
No regional properties for Q5BJZ0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q5BJZ0 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| GATOR2 complex | A multiprotein subcomplex of the GATOR complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, this complex consists of WDR24, WDR59, MIOS, SEH1L, and SEC13. In S. cerevisiae, this complex is referred to as SEACAT and contains the Sea2p, Sea3p, Sea4p, Seh1p, Sec13p proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| arginine binding | Binding to 2-amino-5-(carbamimidamido)pentanoic acid. |
| identical protein binding | Binding to an identical protein or proteins. |
| protein sequestering activity | Binding to a protein to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to L-arginine | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus. |
| negative regulation of TORC1 signaling | Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling. |
| regulation of intracellular signal transduction | Any process that modulates the frequency, rate or extent of intracellular signal transduction. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0V8A3 | CASTOR1 | Cytosolic arginine sensor for mTORC1 subunit 1 | Bos taurus (Bovine) | PR |
| Q8WTX7 | CASTOR1 | Cytosolic arginine sensor for mTORC1 subunit 1 | Homo sapiens (Human) | PR |
| Q9CWQ8 | Castor1 | Cytosolic arginine sensor for mTORC1 subunit 1 | Mus musculus (Mouse) | PR |
| Q63ZZ8 | castor2 | Cytosolic arginine sensor for mTORC1 subunit 2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MELHILEHRV | RVLSLARPGL | WLYTHPLIKL | LFLPSRSRCK | FFSLTETPED | YTLMVDEEGF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KELPPSEFLQ | VAEATWLVMN | VSHSGSVVQA | AGVTKIARSV | IAPLAEHHVS | VLMLSTYQTD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FILVREQDLS | VVIHTLAREF | QIYREVGGEP | VPVTGDDSSN | GFPQAQHGPS | PTVHPIQSPQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NRFCVLTLDP | ETLPAVATTL | IDVLFYSHSV | PKEAASGGPE | STSIPFFAFS | LIEGYISIVM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DAETQKKFPS | DLLLTSSSGE | LWRMVRIGGQ | PLGFDECGIV | AQIAGPLAAV | DVSAYYISTF |
| 310 | 320 | 330 | |||
| NFDHALVPED | EISCVIDILQ | RRQEGLASKD | P |