Q63ZZ8

PR
Gene name
castor2
Protein name
Cytosolic arginine sensor for mTORC1 subunit 2
Names
GATS-like protein 2
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:496428
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

141-220 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q63ZZ8

Entry ID Method Resolution Chain Position Source
AF-Q63ZZ8-F1 Predicted AlphaFoldDB

No variants for Q63ZZ8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q63ZZ8

No associated diseases with Q63ZZ8

3 regional properties for Q63ZZ8

Type Name Position InterPro Accession
domain CASTOR, ACT domain 72 - 140 IPR027795-1
domain CASTOR, ACT domain 262 - 322 IPR027795-2
domain CASTOR1, N-terminal 9 - 69 IPR040778

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
cellular response to L-arginine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus.
negative regulation of TORC1 signaling Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling.
regulation of intracellular signal transduction Any process that modulates the frequency, rate or extent of intracellular signal transduction.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q0V8A3 CASTOR1 Cytosolic arginine sensor for mTORC1 subunit 1 Bos taurus (Bovine) PR
Q8WTX7 CASTOR1 Cytosolic arginine sensor for mTORC1 subunit 1 Homo sapiens (Human) PR
Q9CWQ8 Castor1 Cytosolic arginine sensor for mTORC1 subunit 1 Mus musculus (Mouse) PR
Q5BJZ0 Castor1 Cytosolic arginine sensor for mTORC1 subunit 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MELHILEHRL KVASIAKENI QLFTYGLIKL AFLSSKTRCK FFSLTETPED YTIIVDEEGF
70 80 90 100 110 120
LELPSSEHLS VADATWLALN VVSGGGSSSS SQPIGVTKIA KSVIAPLADQ NISVFMLSTY
130 140 150 160 170 180
QTDFILVRER DLPFVMHTLA AEFTILQVVN GETVAADNLG VTNGFVKPKL VQRPVIHPLS
190 200 210 220 230 240
SPSNMFCVTS LDPYTLPTVT TLLMDVMFYS NGVKDSVVGS EEPGHIRFFS FSLIEGYISL
250 260 270 280 290 300
VMDVQTQQRF PSNLLFTSAS GELWKMVRIG GQPLGFDECG IVAQISEPLA AADIPAYYIS
310 320
TFKFDHALVP EENINGVINA LQVSQAEKH