Q8VEM8
Gene name |
Slc25a3 |
Protein name |
Phosphate carrier protein, mitochondrial |
Names |
Phosphate transport protein, PTP, Solute carrier family 25 member 3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:18674 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VEM8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VEM8-F1 | Predicted | AlphaFoldDB |
13 variants for Q8VEM8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3401516439 | 19 | L>P | No | EVA | |
| rs13464989 | 32 | P>S | No | EVA | |
| rs1131812015 | 143 | Y>N | No | EVA | |
| rs3400845193 | 211 | F>C | No | EVA | |
| rs3400845193 | 211 | F>G | No | EVA | |
| rs3400845193 | 211 | F>Q | No | EVA | |
| rs3400845193 | 211 | F>S | No | EVA | |
| rs3389123351 | 212 | Y>C | No | EVA | |
| rs3389090278 | 226 | T>I | No | EVA | |
| rs3389119987 | 251 | E>D | No | EVA | |
| rs3389133212 | 262 | F>V | No | EVA | |
| rs3389090214 | 294 | A>T | No | EVA | |
| rs3389109921 | 316 | M>I | No | EVA |
No associated diseases with Q8VEM8
3 regional properties for Q8VEM8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Mitochondrial substrate/solute carrier | 58 - 144 | IPR018108-1 |
| repeat | Mitochondrial substrate/solute carrier | 155 - 242 | IPR018108-2 |
| repeat | Mitochondrial substrate/solute carrier | 256 - 335 | IPR018108-3 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of mitochondrial inner membrane | The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| myelin sheath | An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| inorganic phosphate transmembrane transporter activity | Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. |
| protein-containing complex binding | Binding to a macromolecular complex. |
| symporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| mitochondrial phosphate ion transmembrane transport | The process in which a phosphate ion is transported across a mitochondrial membrane, into or out of the mitochondrion. |
| phosphate ion transmembrane transport | The process in which a phosphate is transported across a membrane. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P12234 | SLC25A3 | Phosphate carrier protein, mitochondrial | Bos taurus (Bovine) | PR |
| Q00325 | SLC25A3 | Phosphate carrier protein, mitochondrial | Homo sapiens (Human) | PR |
| P16036 | Slc25a3 | Phosphate carrier protein, mitochondrial | Rattus norvegicus (Rat) | PR |
| P40614 | F01G4.6 | Phosphate carrier protein, mitochondrial | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFSSVAHLAR | ANPFNAPHLQ | LVHDGLSGPR | SPPAPPRRSR | HLAAAAVEEY | SCEFGSMKYY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ALCGFGGVLS | CGLTHTAVVP | LDLVKCRMQV | DPQKYKGIFN | GFSITLKEDG | VRGLAKGWAP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TLIGYSMQGL | CKFGFYEVFK | ALYSNILGEE | NTYLWRTSLY | LASSASAEFF | ADIALAPMEA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AKVRIQTQPG | YANTLREAVP | KMYKEEGLNA | FYKGVAPLWM | RQIPYTMMKF | ACFERTVEAL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YKFVVPKPRS | ECTKAEQLVV | TFVAGYIAGV | FCAIVSHPAD | SVVSVLNKEK | GSTASQVLQR |
| 310 | 320 | 330 | 340 | 350 | |
| LGFRGVWKGL | FARIIMIGTL | TALQWFIYDS | VKVYFRLPRP | PPPEMPESLK | KKLGLTE |