P16036

PR
Gene name
Slc25a3 (Phc)
Protein name
Phosphate carrier protein, mitochondrial
Names
Phosphate transport protein, PTP, Solute carrier family 25 member 3
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-75 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P16036

Entry ID Method Resolution Chain Position Source
AF-P16036-F1 Predicted AlphaFoldDB

No variants for P16036

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P16036

No associated diseases with P16036

3 regional properties for P16036

Type Name Position InterPro Accession
repeat Mitochondrial substrate/solute carrier 57 - 143 IPR018108-1
repeat Mitochondrial substrate/solute carrier 154 - 241 IPR018108-2
repeat Mitochondrial substrate/solute carrier 255 - 334 IPR018108-3

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of mitochondrial inner membrane The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
inorganic phosphate transmembrane transporter activity Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
phosphate:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in).
protein-containing complex binding Binding to a macromolecular complex.

2 GO annotations of biological process

Name Definition
mitochondrial phosphate ion transmembrane transport The process in which a phosphate ion is transported across a mitochondrial membrane, into or out of the mitochondrion.
phosphate ion transmembrane transport The process in which a phosphate is transported across a membrane.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P12234 SLC25A3 Phosphate carrier protein, mitochondrial Bos taurus (Bovine) PR
Q00325 SLC25A3 Phosphate carrier protein, mitochondrial Homo sapiens (Human) PR
Q8VEM8 Slc25a3 Phosphate carrier protein, mitochondrial Mus musculus (Mouse) PR
P40614 F01G4.6 Phosphate carrier protein, mitochondrial Caenorhabditis elegans PR
10 20 30 40 50 60
MFSSVAHLAR ANPFNAPHLQ LVHDVSGPRS PPGPPRRSRH LAAAAVEGYS CEFGSMKYYA
70 80 90 100 110 120
LCGFGGVLSC GLTHTAVVPL DLVKCRMQVD PQKYKGIFNG FSITLKEDGV RGLAKGWAPT
130 140 150 160 170 180
LIGYSMQGLC KFGFYEVFKA LYSNILGEEN TYLWRTSLYL AASASAEFFA DIALAPMEAA
190 200 210 220 230 240
KVRIQTQPGY ANTLREAVPK MYKEEGLNAF YKGVAPVWMR QIPYTMMKFA CFERTVEALY
250 260 270 280 290 300
KFVVPKPRSE CTKAEQLVVT FVAGYIAGVF CAIVSHPADS VVSVLNKEKG STASQVLQRL
310 320 330 340 350
GFRGVWKGLF ARIIMIGTLT ALQWFIYDSV KVYFRLPRPP PPEMPESLKK KLGLTE