AiPD: Autoinhibited Protein Database

Gene name	SLC25A3 (PHC)
Protein name	Phosphate carrier protein, mitochondrial
Names	Phosphate transport protein, PTP, Solute carrier family 25 member 3
Species	Bos taurus (Bovine)
KEGG Pathway	bta:282477
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-84 (Predicted disordered autoinhibitory region) PR

1-84 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P12234-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs468360711	3	S>A	No	EVA
rs468360711	3	S>P	No	EVA
rs435337169	5	V>L	No	EVA
rs456982669	6	V>G	No	EVA
rs475593457	7	H>P	No	EVA
rs432837767	11	A>S	No	EVA
rs451347153	12	N>T	No	EVA
rs441552625	15	N>K	No	EVA
rs475211256	17	P>R	No	EVA
rs463912151	18	H>P	No	EVA
rs482403893	19	L>V	No	EVA
rs446085316	20	Q>K	No	EVA
rs458001537	20	Q>L	No	EVA
rs479582037	21	L>W	No	EVA
rs450710919	30	R>P	No	EVA
rs432864649	31	S>G	No	EVA
rs451384010	31	S>R	No	EVA
rs433514212	32	D>A	No	EVA
rs433514212	32	D>G	No	EVA
rs472999146	32	D>H	No	EVA
rs442274536	37	P>R	No	EVA
rs475783347	38	G>A	No	EVA
rs457567832	38	G>R	No	EVA
rs479620990	44	R>G	No	EVA
rs434085101	55	Y>N	No	EVA
rs455713111	57	C>W	No	EVA
rs474225467	58	D>E	No	EVA
rs463985019	58	D>V	No	EVA
rs444436049	59	Y>*	No	EVA
rs462942615	60	G>R	No	EVA
rs471726172	62	G>A	No	EVA
rs460355409	63	R>K	No	EVA
rs460355409	63	R>T	No	EVA
rs448982122	64	F>L	No	EVA
rs460957052	66	I>T	No	EVA
rs449635588	76	C>W	No	EVA
rs464782066	80	H>Q	No	EVA
rs434124556	83	L>F	No	EVA
rs467011736	83	L>V	No	EVA
rs474348476	89	V>I	No	EVA
rs468536103	150	N>Y	No	EVA
rs447701617	156	N>K	No	EVA
rs459893116	160	W>C	No	EVA
rs448501966	198	N>Y	No	EVA
rs469986830	199	T>P	No	EVA
rs437080072	204	A>D	No	EVA
rs445870594	214	K>N	No	EVA
rs439643160	307	G>R	No	EVA
rs440301874	308	F>L	No	EVA
rs479828564	308	F>S	No	EVA
rs461975132	309	R>G	No	EVA
rs480549776	309	R>K	No	EVA
rs444912403	359	G>E	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P12234

		Description
EC Number
Subcellular Localization	Mitochondrion inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
integral component of mitochondrial inner membrane	The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Name	Definition
inorganic phosphate transmembrane transporter activity	Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
protein-containing complex binding	Binding to a macromolecular complex.
symporter activity	Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

Name	Definition
mitochondrial phosphate ion transmembrane transport	The process in which a phosphate ion is transported across a mitochondrial membrane, into or out of the mitochondrion.
phosphate ion transmembrane transport	The process in which a phosphate is transported across a membrane.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q00325	SLC25A3	Phosphate carrier protein, mitochondrial	Homo sapiens (Human)	PR
Q8VEM8	Slc25a3	Phosphate carrier protein, mitochondrial	Mus musculus (Mouse)	PR
P16036	Slc25a3	Phosphate carrier protein, mitochondrial	Rattus norvegicus (Rat)	PR
P40614	F01G4.6	Phosphate carrier protein, mitochondrial	Caenorhabditis elegans	PR