Q8VDJ3
PR
Gene name |
Hdlbp |
Protein name |
Vigilin |
Names |
High density lipoprotein-binding protein, HDL-binding protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:110611 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VDJ3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VDJ3-F1 | Predicted | AlphaFoldDB |
49 variants for Q8VDJ3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388489460 | 21 | P>L | No | EVA | |
| rs3388489051 | 22 | Q>H | No | EVA | |
| rs1134001941 | 134 | D>Y | No | EVA | |
| rs3412946968 | 254 | T>P | No | EVA | |
| rs3388489595 | 257 | N>K | No | EVA | |
| rs3388489928 | 279 | Q>R | No | EVA | |
| rs3388492832 | 309 | Y>F | No | EVA | |
| rs3388489437 | 311 | I>S | No | EVA | |
| rs3388491698 | 397 | V>I | No | EVA | |
| rs3388492061 | 403 | E>V | No | EVA | |
| rs3388492006 | 420 | A>V | No | EVA | |
| rs3388492805 | 430 | D>N | No | EVA | |
| rs3388490388 | 515 | E>V | No | EVA | |
| rs3388489450 | 530 | I>T | No | EVA | |
| rs3388492801 | 543 | N>Y | No | EVA | |
| rs3388489832 | 576 | D>N | No | EVA | |
| rs3388491235 | 584 | I>V | No | EVA | |
| rs3388489323 | 589 | F>V | No | EVA | |
| rs3388491757 | 590 | K>E | No | EVA | |
| rs3388489385 | 600 | G>E | No | EVA | |
| rs3388492940 | 606 | K>N | No | EVA | |
| rs3388489592 | 607 | I>F | No | EVA | |
| rs13465906 | 628 | I>V | No | EVA | |
| rs3388489300 | 629 | I>F | No | EVA | |
| rs3388489891 | 655 | E>D | No | EVA | |
| rs3388490369 | 677 | R>H | No | EVA | |
| rs3388490980 | 678 | S>A | No | EVA | |
| rs3388489067 | 690 | F>Y | No | EVA | |
| rs30377746 | 692 | V>M | No | EVA | |
| rs3388490400 | 765 | A>T | No | EVA | |
| rs3388492828 | 775 | T>A | No | EVA | |
| rs3388490983 | 799 | N>T | No | EVA | |
| rs3390254532 | 829 | E>* | No | EVA | |
| rs3388492040 | 904 | N>K | No | EVA | |
| rs3388491688 | 917 | V>D | No | EVA | |
| rs3388489830 | 1055 | L>R | No | EVA | |
| rs3388491095 | 1056 | S>N | No | EVA | |
| rs3388489930 | 1072 | G>* | No | EVA | |
| rs3388491030 | 1087 | Q>* | No | EVA | |
| rs3388491258 | 1108 | K>E | No | EVA | |
| rs3388489383 | 1139 | H>Q | No | EVA | |
| rs3388489613 | 1141 | R>L | No | EVA | |
| rs3388488901 | 1148 | K>N | No | EVA | |
| rs3388490382 | 1188 | D>E | No | EVA | |
| rs13465904 | 1220 | R>K | No | EVA | |
| rs3388492073 | 1222 | P>S | No | EVA | |
| rs3388489666 | 1231 | A>T | No | EVA | |
| rs3410540600 | 1242 | P>A | No | EVA | |
| rs3390353026 | 1243 | D>H | No | EVA |
No associated diseases with Q8VDJ3
28 regional properties for Q8VDJ3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | K Homology domain | 149 - 217 | IPR004087-1 |
| domain | K Homology domain | 221 - 289 | IPR004087-2 |
| domain | K Homology domain | 294 - 362 | IPR004087-3 |
| domain | K Homology domain | 363 - 429 | IPR004087-4 |
| domain | K Homology domain | 434 - 502 | IPR004087-5 |
| domain | K Homology domain | 506 - 575 | IPR004087-6 |
| domain | K Homology domain | 580 - 648 | IPR004087-7 |
| domain | K Homology domain | 652 - 721 | IPR004087-8 |
| domain | K Homology domain | 726 - 795 | IPR004087-9 |
| domain | K Homology domain | 799 - 868 | IPR004087-10 |
| domain | K Homology domain | 872 - 972 | IPR004087-11 |
| domain | K Homology domain | 973 - 1039 | IPR004087-12 |
| domain | K Homology domain | 1051 - 1122 | IPR004087-13 |
| domain | K Homology domain | 1126 - 1195 | IPR004087-14 |
| domain | K Homology domain, type 1 | 154 - 212 | IPR004088-1 |
| domain | K Homology domain, type 1 | 225 - 285 | IPR004088-2 |
| domain | K Homology domain, type 1 | 298 - 357 | IPR004088-3 |
| domain | K Homology domain, type 1 | 368 - 425 | IPR004088-4 |
| domain | K Homology domain, type 1 | 438 - 498 | IPR004088-5 |
| domain | K Homology domain, type 1 | 512 - 571 | IPR004088-6 |
| domain | K Homology domain, type 1 | 584 - 644 | IPR004088-7 |
| domain | K Homology domain, type 1 | 656 - 717 | IPR004088-8 |
| domain | K Homology domain, type 1 | 732 - 791 | IPR004088-9 |
| domain | K Homology domain, type 1 | 805 - 865 | IPR004088-10 |
| domain | K Homology domain, type 1 | 877 - 968 | IPR004088-11 |
| domain | K Homology domain, type 1 | 974 - 1033 | IPR004088-12 |
| domain | K Homology domain, type 1 | 1056 - 1118 | IPR004088-13 |
| domain | K Homology domain, type 1 | 1131 - 1191 | IPR004088-14 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| high-density lipoprotein particle | A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| polysome | A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cholesterol metabolic process | The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. |
| lipid transport | The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P81021 | HDLBP | Vigilin | Gallus gallus (Chicken) | PR |
| Q24009 | BicC | Protein bicaudal C | Drosophila melanogaster (Fruit fly) | PR |
| Q00341 | HDLBP | Vigilin | Homo sapiens (Human) | PR |
| Q9Z1A6 | Hdlbp | Vigilin | Rattus norvegicus (Rat) | PR |
| P34307 | C06G4.1 | KH domain-containing protein C06G4.1 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSVAVLTQE | SFAEHRSGLV | PQQIKVATLN | SEEENDPPTY | KDAFPPLPEK | AACLESAQEP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AGAWSNKIRP | IKASVITQVF | HVPLEERKYK | DMNQFGEGEQ | AKICLEIMQR | TGAHLELSLA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KDQGLSIMVS | GKLDAVMKAR | KDIVARLQTQ | ASATVPIPKE | HHRFVIGKNG | EKLQDLELKT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ATKIQIPRPD | DPSNQIKITG | TKEGIEKARH | EVLLISAEQD | KRAVERLEVE | KAFHPFIAGP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YNRLVGEIMQ | ETGTRINIPP | PSVNRTEIVF | TGEKEQLAQA | VARIKKIYEE | KKKKTTTIAV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EVKKSQHKYV | IGPKGNSLQE | ILERTGVSVE | IPPSDSISET | VILRGEPEKL | GQALTEVYAK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ANSFTVSSVS | APSWLHRFII | GKKGQNLAKI | TQQMPKVHIE | FTEGEDKITL | EGPTEDVNVA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QEQIEGMVKD | LINRMDYVEI | NIDHKFHRHL | IGKSGANINR | IKDQYKVSVR | IPPDSEKSNL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IRIEGDPQGV | QQAKRELLEL | ASRMENERTK | DLIIEQRFHR | TIIGQKGERI | REIRDKFPEV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IINFPDPAQK | SDIVQLRGPK | NEVEKCTKYM | QKMVADLVEN | SYSISVPIFK | QFHKNIIGKG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GANIKKIREE | SNTKIDLPAE | NSNSETIIIT | GKRANCEAAR | SRILSIQKDL | ANIAEVEVSI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| PAKLHNSLIG | TKGRLIRSIM | EECGGVHIHF | PVEGSGSDTV | VIRGPSSDVE | KAKKQLLHLA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EEKQTKSFTV | DIRAKPEYHK | FLIGKGGGKI | RKVRDSTGAR | IIFPAAEDKD | QDLITIIGKE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DAVREAQKEL | EALIQNLENV | VEDYMLVDPK | HHRHFVIRRG | QVLREIAEEY | GGVMVSFPRS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| GTQSDKVTLK | GAKDCVEAAK | KRIQEIIEDL | EAQVTVECAI | PQKFHRSVMG | PKGSRIQQIT |
| 910 | 920 | 930 | 940 | 950 | 960 |
| RDYNVQIKFP | DREENPVHSV | EPSIQENGDE | AGEGREAKET | DPGSPRRCDI | IIISGRKEKC |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| EAAKEALEAL | VPVTIEVEVP | FDLHRYIIGQ | KGSGIRKMMD | EFEVNIHVPA | PELQSDTIAI |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| TGLAANLDRA | KAGLLDRVKE | LQAEQEDRAL | RSFKLSVTVD | PKYHPKIIGR | KGAVITQIRL |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| EHEVNIQFPD | KDDGNQPQDQ | ITITGYEKNT | EAARDAILKI | VGELEQMVSE | DVPLDHRVHA |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| RIIGARGKAI | RKIMDEFKVD | IRFPQSGAPD | PNCVTVTGLP | ENVEEAIDHI | LNLEEEYLAD |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| VVDSEALQVY | MKPPAHEESR | APSKGFVVRD | APWTSNSSEK | APDMSSSEEF | PSFGAQVAPK |
| TLPWGPKR |