AiPD: Autoinhibited Protein Database

Q8TBJ4

Gene name	PLPPR1
Protein name	Phospholipid phosphatase-related protein type 1
Names	Inactive 2-lysophosphatidate phosphatase PLPPR1, Lipid phosphate phosphatase-related protein type 1, Plasticity-related gene 3 protein, PRG-3
Species	Homo sapiens (Human)
KEGG Pathway	hsa:54886
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

251-325 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

251-325 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8TBJ4

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8TBJ4-F1	Predicted				AlphaFoldDB

221 variants for Q8TBJ4

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	1	M>?	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374368095 rs1404237527	2	A>T		No	ClinGen gnomAD
rs75832966 CA5160249	3	V>A		No	ExAC gnomAD ClinGen
rs75832966 CA197262535	3	V>G		No	ClinGen ExAC gnomAD
rs1458167241 CA374368102	3	V>L		No	ClinGen TOPMed gnomAD
rs928324444 CA197262536	6	N>D		No	ClinGen TOPMed
CA374368121 rs1588062955	6	N>S		No	Ensembl ClinGen
CA374368130 rs1176842247	7	T>S		No	ClinGen TOPMed gnomAD
CA5160252 rs200860367	9	R>Q		No	ExAC TOPMed gnomAD ClinGen
rs41296085 CA5160253	12	S>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA197262537 rs1023937851	14	I>L		No	Ensembl ClinGen
rs747599995 CA5160257	16	C>Y		No	ClinGen ExAC gnomAD
rs146000696 CA5160259	18	I>M		No	ESP ExAC TOPMed gnomAD ClinGen
CA374368203 rs1353992366	18	I>T		No	ClinGen TOPMed
CA374368200 rs1301352674	18	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	21	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1251928208 CA374368241	22	L>F		No	Ensembl ClinGen
rs748916921 CA5160279	24	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC gnomAD ClinGen NCI-TCGA
CA5160280 rs770579216	25	M>V		No	ClinGen ExAC gnomAD
rs1465004638 CA374368270	26	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	TOPMed ClinGen NCI-TCGA
CA5160281 rs778577480	28	T>A		No	ClinGen ExAC gnomAD
rs1186319539 CA374368283	29	V>L		No	ClinGen gnomAD
CA374368295 rs1269459646	31	L>F		No	TOPMed ClinGen
rs1406465588 CA374368304	32	A>V		No	gnomAD ClinGen
TCGA novel	37	C>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374368339 rs1451048683	37	C>G		No	TOPMed gnomAD ClinGen
CA374368338 rs1451048683	37	C>R		No	ClinGen TOPMed gnomAD
rs568942556 CA5160285	37	C>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs769782936 CA5160286	38	T>S		No	ExAC gnomAD ClinGen
rs1291219087 CA374368370 COSM3786073	41	F>L	pancreas [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA374368378 rs1588104643	42	Q>H		No	ClinGen Ensembl
CA374368386 rs1381022673	44	H>D		No	ClinGen gnomAD
TCGA novel	44	H>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA197271861 rs867093135	47	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs117491062 CA197271863	52	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs868474605 CA197271862	52	D>N		No	ClinGen Ensembl
rs368320785 CA5160290	53	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	58	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5160291 rs759889251	58	P>S		No	ClinGen ExAC TOPMed gnomAD
CA374368489 rs759889251	58	P>T		No	ClinGen ExAC TOPMed gnomAD
rs866810351 CA197271864	61	G>E		No	ClinGen Ensembl
CA374368514 rs1239610230	62	T>A		No	ClinGen gnomAD
TCGA novel	62	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374368569 rs1564022795	69	T>N		No	ClinGen Ensembl
CA374368579 rs763545864	71	L>V		No	ExAC TOPMed gnomAD ClinGen
CA5160296 rs753323821	72	V>M		No	ClinGen ExAC TOPMed gnomAD
CA5160297 rs756874307	73	L>F		No	ExAC gnomAD ClinGen
rs778618938 CA5160298	74	Y>C		No	ExAC TOPMed gnomAD ClinGen
rs778618938 CA374368597	74	Y>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	75	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1310652122 CA374368620	78	A>P		No	ClinGen gnomAD
TCGA novel	78	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs372236848 CA5160299	79	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs754637630 CA5160301	82	T>A		No	ClinGen ExAC TOPMed gnomAD
rs746971581 CA5160302	82	T>I		No	ExAC gnomAD ClinGen
rs1256151072 CA374368646	83	A>T		No	ClinGen TOPMed
rs768569090 CA5160303	84	I>V		No	ClinGen ExAC gnomAD
CA5160322 rs758081307	87	I>F		No	ClinGen ExAC gnomAD
CA374368689 rs758081307	87	I>L		No	ExAC gnomAD ClinGen
rs1436874410 CA374368695	88	G>R		No	ClinGen TOPMed
rs1166917256 CA374368716	91	S>P		No	ClinGen TOPMed gnomAD
CA374368715 rs1166917256	91	S>T		No	TOPMed gnomAD ClinGen
rs1588111198 CA374368724	92	M>T		No	Ensembl ClinGen
CA197273561 rs201250597	92	M>V		No	ClinGen TOPMed gnomAD
rs201289914 CA5160324	95	I>V		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs754925689 CA5160325	98	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs781184153 CA5160326	99	R>G		No	ClinGen ExAC gnomAD
CA197273564 rs866615719	101	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA374368787 rs866615719	101	S>Y		No	ClinGen gnomAD
TCGA novel	103	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774363945 CA5160329	103	I>T		No	ExAC gnomAD ClinGen
CA374368800 rs1219699759	104	A>T		No	gnomAD ClinGen
CA374368811 rs1333350599	105	Q>R		No	gnomAD ClinGen
CA197273565 rs370046405	108	T>I		No	ESP TOPMed ClinGen
CA374368836 rs1212081542	109	I>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	gnomAD ClinGen NCI-TCGA
rs772217528 CA5160331	109	I>T		No	ClinGen ExAC TOPMed gnomAD
CA5160332 rs775845832	110	L>V		No	ClinGen ExAC gnomAD
CA5160334 rs769113387	112	G>E		No	ClinGen ExAC gnomAD
rs1260639911 CA374368851	112	G>R		No	ClinGen gnomAD
TCGA novel	113	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA197273567 rs868578200	119	P>L		No	Ensembl ClinGen
rs1588111267 CA374368901	119	P>T		No	Ensembl ClinGen
CA374368910 rs1276194344	120	L>S		No	ClinGen gnomAD
rs1443413009 CA374368915	121	L>F		No	TOPMed ClinGen
CA197273568 rs924333774	122	R>Q		No	gnomAD ClinGen
CA374368929 rs1400238835	123	R>S		No	ClinGen gnomAD
CA374368942 rs1362751037	125	I>M		No	ClinGen gnomAD
rs761281978 CA5160336 COSM752277	125	I>V	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen cosmic curated NCI-TCGA
rs764865317 CA5160337	127	F>S		No	ExAC gnomAD ClinGen
rs767375015 CA5160361	130	V>L		No	ExAC gnomAD ClinGen
CA5160362 rs752369015	132	A>T		No	ExAC gnomAD ClinGen
rs1400457456 CA374368999	132	A>V		No	ClinGen gnomAD
rs1564033853 CA374369017	135	L>H		No	ClinGen Ensembl
CA5160363 rs375650714	135	L>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA5160364 rs777674634	137	A>T		No	ExAC TOPMed gnomAD ClinGen
CA5160365 rs750570003	140	I>V		No	ExAC gnomAD ClinGen
CA5160367 rs374506978	144	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	144	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	145	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs975934254 CA197276248	147	V>A		No	ClinGen Ensembl
CA374369102 rs1564033868	148	V>A		No	Ensembl ClinGen
CA5160369 rs149405756	148	V>L		No	ClinGen 1000Genomes ExAC gnomAD
CA374369119 rs1393379158	151	H>P		No	TOPMed ClinGen
CA374369118 rs1173532569	151	H>Y		No	ClinGen TOPMed gnomAD
CA374369148 rs1378260774	155	Y>F		No	gnomAD ClinGen
rs773821062 CA5160373	161	K>*		No	ClinGen ExAC
CA5160374 rs150814920	162	P>L		No	ESP ExAC gnomAD ClinGen
rs1283268204 CA374369193	162	P>S		No	ClinGen Ensembl
rs773692925 CA5160376	163	N>D		No	ExAC TOPMed gnomAD ClinGen
rs759232206 CA5160377	164	Y>C		No	ClinGen ExAC gnomAD
rs767021755 CA5160378	165	T>P		No	ExAC TOPMed gnomAD ClinGen
CA5160379 rs775413062	165	T>S		No	ExAC gnomAD ClinGen
rs760459469 CA5160380	166	S>R		No	ExAC gnomAD ClinGen
CA197276251 rs3209400	170	Q>*		No	Ensembl ClinGen
rs764061295 CA5160381	171	A>V		No	ExAC gnomAD ClinGen
rs1364632590 CA374369261	172	H>Q		No	ClinGen TOPMed
rs1193151487 CA374369265	173	H>Y		No	gnomAD ClinGen
CA5160384 rs530545562	174	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
COSM218967 rs751532084 CA5160385	178	N>S	pancreas [Cosmic]	No	ExAC gnomAD ClinGen cosmic curated
rs1452979767 CA374369311	179	G>E		No	ClinGen TOPMed
rs998355165 CA197276252	180	N>I		No	ClinGen TOPMed
TCGA novel	180	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	182	C>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1401739536 CA374369352	185	D>G		No	ClinGen gnomAD
rs768378346 CA197276253 COSM1458948	186	L>M	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	Ensembl ClinGen cosmic curated NCI-TCGA
CA374369360 rs1282708268	187	E>K		No	ClinGen TOPMed
rs756644661 CA197276254	188	V>M		No	Ensembl ClinGen
CA374369377 rs1204069043	189	I>T		No	ClinGen TOPMed
CA374369373 rs1461331206	189	I>V		No	gnomAD ClinGen
rs1388171428 CA374369403	193	R>Q		No	gnomAD ClinGen
CA5160389 rs571135401	193	R>W		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA374369455 rs1318531360	201	A>T		No	gnomAD ClinGen
rs1263782200 CA374369501	208	A>T		No	ClinGen gnomAD
rs1489535473 CA374369507	209	L>I		No	TOPMed gnomAD ClinGen
rs771824283 CA5160395	211	A>V		No	ExAC gnomAD ClinGen
CA5160396 rs774975567	212	T>M		No	ClinGen ExAC TOPMed gnomAD
CA197276636 rs754779962	213	M>I		No	gnomAD ClinGen
rs1300855496 CA374369572	216	T>I		No	ClinGen gnomAD
rs1381272188 CA374369582	218	T>A		No	ClinGen gnomAD
CA374369593 rs1308667603	219	I>M		No	ClinGen gnomAD
rs1228752245 CA374369591	219	I>T		No	gnomAD ClinGen
CA5160415 rs200667385	221	T>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ESP ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA5160414 rs200667385	221	T>M	Variant assessed as Somatic; 4.628e-05 impact. [NCI-TCGA]	No	ESP ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA5160418 rs147722670	223	S>N		No	ClinGen ESP ExAC gnomAD
CA374369624 rs1231232340	224	S>N		No	ClinGen TOPMed
CA5160419 rs776464922	225	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ExAC gnomAD ClinGen NCI-TCGA
CA374369630 rs1208537784	225	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	gnomAD ClinGen NCI-TCGA
rs1588122894 CA374369639	227	A>P		No	Ensembl ClinGen
CA5160421 rs769808567	227	A>V		No	ExAC gnomAD ClinGen
CA374369661 rs1178515380	230	V>A		No	ClinGen gnomAD
rs1159925949 CA374369679	233	L>H		No	ClinGen gnomAD
CA197276639 rs201352342	234	G>R		No	ClinGen Ensembl
rs1413492552 CA374369692	235	T>S		No	gnomAD ClinGen
rs760990429 CA5160426	236	L>F		No	ExAC TOPMed gnomAD ClinGen
rs760990429 CA374369694	236	L>V		No	ExAC TOPMed gnomAD ClinGen
rs1316439434 CA374369699	237	C>G		No	TOPMed ClinGen
TCGA novel	238	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374369706 rs1360638794	238	T>P		No	gnomAD ClinGen
CA5160427 rs189030340	240	F>L		No	1000Genomes ExAC TOPMed gnomAD ClinGen
rs1321150074 CA374369739	243	G>A		No	ClinGen TOPMed
TCGA novel	243	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750918337 CA5160431	246	R>Q		No	ExAC gnomAD ClinGen
rs367663778 CA5160430	246	R>W		No	ESP ExAC gnomAD ClinGen
rs1330958739 CA374369759	247	V>I		No	TOPMed gnomAD ClinGen
rs746467901 CA374369775	249	E>G		No	ExAC TOPMed gnomAD ClinGen
CA374369771 rs1281208258	249	E>K		No	ClinGen gnomAD
rs746467901 CA5160434	249	E>V		No	ClinGen ExAC TOPMed gnomAD
CA5160435 rs768359809	250	Y>C		No	ExAC gnomAD ClinGen
rs371486478 CA197276640	251	R>Q		No	ClinGen ESP
CA5160436 rs780787669	251	R>W		No	ClinGen ExAC TOPMed gnomAD
CA5160438 rs769495669	255	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1189046666 CA374369826	257	V>L		No	ClinGen gnomAD
CA5160441 rs199633082	260	G>C		No	1000Genomes ExAC gnomAD ClinGen
CA374369844 rs199633082	260	G>S		No	ClinGen 1000Genomes ExAC gnomAD
CA374369864 rs1234856864	263	L>M		No	ClinGen TOPMed
rs1169692729 CA374369881	266	A>T		No	gnomAD ClinGen
CA5160443 rs760832752	269	L>M		No	ExAC gnomAD ClinGen
CA374248445 rs1307147972	272	G>E		No	TOPMed ClinGen
rs777477569 CA5160477	273	M>I		No	ExAC TOPMed gnomAD ClinGen
CA5160475 rs752191646	273	M>L		No	ExAC gnomAD ClinGen
CA5160476 rs755780295	273	M>T		No	ClinGen ExAC gnomAD
TCGA novel	274	C>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1368406232 CA374248501	277	H>R		No	ClinGen TOPMed
rs1324816491 CA374248555	281	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA5160479 rs757098094	281	G>R		No	ExAC gnomAD ClinGen
rs778803378 CA5160480 COSM1103296	282	T>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ExAC gnomAD ClinGen cosmic curated NCI-TCGA
CA5160482 rs372382236	283	Q>R		No	ESP ExAC TOPMed gnomAD ClinGen
CA196919449 rs866065187	284	G>E		No	ClinGen Ensembl
CA374248595 rs1419348572	285	S>T		No	gnomAD ClinGen
rs1296631806 CA374248626	288	K>E		No	ClinGen TOPMed gnomAD
CA374248639 rs376477018	289	P>S		No	ESP ExAC TOPMed gnomAD ClinGen
CA5160484 rs376477018	289	P>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ESP ExAC TOPMed gnomAD ClinGen NCI-TCGA
TCGA novel	292	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1333911204 CA374248673	292	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1045674628 CA196919510	293	D>E		No	ClinGen TOPMed gnomAD
rs1031778448 CA196919486	293	D>G		No	ClinGen TOPMed gnomAD
rs1238762922 CA374248701	294	P>H		No	gnomAD ClinGen
rs371399190 CA5160486	294	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ESP ExAC TOPMed gnomAD ClinGen NCI-TCGA
rs371399190 CA5160487	294	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs200604503 CA5160488	295	R>C	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	1000Genomes ExAC TOPMed gnomAD ClinGen NCI-TCGA
rs41274977 CA5160489	295	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs760048467 CA5160490	296	G>E		No	ClinGen ExAC gnomAD
CA374248731 rs1440658982	297	V>E		No	ClinGen gnomAD
CA5160492 rs752215412	298	P>L		No	ExAC gnomAD ClinGen
rs768054227 CA5160491	298	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1156932528 CA374248761	300	M>T		No	gnomAD ClinGen
CA196919620 rs758925822	301	A>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA196919608 rs866850807	301	A>T		No	ClinGen gnomAD
rs377300989 CA5160493	308	P>S		No	ESP ExAC TOPMed gnomAD ClinGen
CA374248881 rs1172368348	311	T>P		No	gnomAD ClinGen
rs1234596135 CA374248894	312	L>V		No	TOPMed ClinGen
CA374248925 rs1400467866	314	A>V		No	TOPMed gnomAD ClinGen
rs749513889 CA5160504	317	H>Q		No	ExAC TOPMed gnomAD ClinGen
rs771081264 CA5160505	318	S>F		No	ExAC gnomAD ClinGen
CA5160506 rs140912404	319	A>V		No	ESP ExAC TOPMed gnomAD ClinGen
TCGA novel	320	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5160508 rs772495204	321	M>V		No	ClinGen ExAC gnomAD
CA5160509 rs776044397	322	T>A		No	ClinGen ExAC TOPMed gnomAD
CA374249735 rs1225180391	323	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
COSM1319675 CA374249768 rs1355089096	325	T>I	Variant assessed as Somatic; impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	TOPMed ClinGen cosmic curated NCI-TCGA
rs1283626316 CA374249772	326	T>R		No	gnomAD ClinGen

No associated diseases with Q8TBJ4

1 regional properties for Q8TBJ4

Type	Name	Position	InterPro Accession
domain	Phosphatidic acid phosphatase type 2/haloperoxidase	128 - 274	IPR000326

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Multi-pass membrane protein Cell projection, neuron projection
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
neuron projection	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name	Definition
lipid phosphatase activity	Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate.
phosphatidate phosphatase activity	Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

4 GO annotations of biological process

Name	Definition
nervous system development	The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
phospholipid dephosphorylation	The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents.
phospholipid metabolic process	The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

7 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O14495	PLPP3	Phospholipid phosphatase 3	Homo sapiens (Human)	PR
Q99JY8	Plpp3	Phospholipid phosphatase 3	Mus musculus (Mouse)	PR
Q8BFZ2	Plppr1	Phospholipid phosphatase-related protein type 1	Mus musculus (Mouse)	PR
P97544	Plpp3	Phospholipid phosphatase 3	Rattus norvegicus (Rat)	PR
Q6WAY2	Plppr1	Phospholipid phosphatase-related protein type 1	Rattus norvegicus (Rat)	PR
A4II83	plppr1	Phospholipid phosphatase-related protein type 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q6IQH6	plppr1	Phospholipid phosphatase-related protein type 1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MAVGNNTQRS	YSIIPCFIFV	ELVIMAGTVL	LAYYFECTDT	FQVHIQGFFC	QDGDLMKPYP
70	80	90	100	110	120
GTEEESFITP	LVLYCVLAAT	PTAIIFIGEI	SMYFIKSTRE	SLIAQEKTIL	TGECCYLNPL
130	140	150	160	170	180
LRRIIRFTGV	FAFGLFATDI	FVNAGQVVTG	HLTPYFLTVC	KPNYTSADCQ	AHHQFINNGN
190	200	210	220	230	240
ICTGDLEVIE	KARRSFPSKH	AALSIYSALY	ATMYITSTIK	TKSSRLAKPV	LCLGTLCTAF
250	260	270	280	290	300
LTGLNRVSEY	RNHCSDVIAG	FILGTAVALF	LGMCVVHNFK	GTQGSPSKPK	PEDPRGVPLM
310	320
AFPRIESPLE	TLSAQNHSAS	MTEVT