A4II83

PR
Gene name
plppr1
Protein name
Phospholipid phosphatase-related protein type 1
Names
Inactive 2-lysophosphatidate phosphatase PLPPR1, Lipid phosphate phosphatase-related protein type 1
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:100124964
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

256-325 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4II83

Entry ID Method Resolution Chain Position Source
AF-A4II83-F1 Predicted AlphaFoldDB

No variants for A4II83

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4II83

No associated diseases with A4II83

1 regional properties for A4II83

Type Name Position InterPro Accession
domain Phosphatidic acid phosphatase type 2/haloperoxidase 128 - 275 IPR000326

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Cell projection, neuron projection
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
lipid phosphatase activity Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate.
phosphatidate phosphatase activity Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

4 GO annotations of biological process

Name Definition
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
phospholipid dephosphorylation The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents.
phospholipid metabolic process The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O14495 PLPP3 Phospholipid phosphatase 3 Homo sapiens (Human) PR
Q8TBJ4 PLPPR1 Phospholipid phosphatase-related protein type 1 Homo sapiens (Human) PR
Q99JY8 Plpp3 Phospholipid phosphatase 3 Mus musculus (Mouse) PR
Q8BFZ2 Plppr1 Phospholipid phosphatase-related protein type 1 Mus musculus (Mouse) PR
P97544 Plpp3 Phospholipid phosphatase 3 Rattus norvegicus (Rat) PR
Q6WAY2 Plppr1 Phospholipid phosphatase-related protein type 1 Rattus norvegicus (Rat) PR
Q6IQH6 plppr1 Phospholipid phosphatase-related protein type 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MALETNTHRS YSIIPCFIFV ELVIMAGTVL LSYYFECTDT FQVHIQGFFC QDGNLMKPYP
70 80 90 100 110 120
GTEDESFISP LVLYCVLAAT PTAIIFIGEV TTYFIKSTRE NLIVQEKMIL TGECCYLNPL
130 140 150 160 170 180
FRRIIRFIGV FAFGLFATDI FVNAGQVVTG NLTPYFLTVC KPNYTASDCL IYHQFINSAN
190 200 210 220 230 240
ICTGDPEVIE KARRSFPSKH AALSIYSALY ATMYITSTIK TKSSRLAKPV LCLGTLCCAF
250 260 270 280 290 300
LTGLNRVSEY RNHCVDVIGG FILGTAIALF LGLCVVHNFK GLYGAQCKPK PEDPRGVPLM
310 320
AFPRVESPLE TLSAQNHSSS MTEVT