Q6IQH6
Gene name |
plppr1 (lppr1) |
Protein name |
Phospholipid phosphatase-related protein type 1 |
Names |
Inactive 2-lysophosphatidate phosphatase PLPPR1, Lipid phosphate phosphatase-related protein type 1 |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:415222 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6IQH6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6IQH6-F1 | Predicted | AlphaFoldDB |
No variants for Q6IQH6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6IQH6 | |||||
No associated diseases with Q6IQH6
1 regional properties for Q6IQH6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phosphatidic acid phosphatase type 2/haloperoxidase | 127 - 276 | IPR000326 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| lipid phosphatase activity | Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate. |
| phosphatidate phosphatase activity | Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| phospholipid dephosphorylation | The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. |
| phospholipid metabolic process | The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8TBJ4 | PLPPR1 | Phospholipid phosphatase-related protein type 1 | Homo sapiens (Human) | PR |
| Q8BFZ2 | Plppr1 | Phospholipid phosphatase-related protein type 1 | Mus musculus (Mouse) | PR |
| Q6WAY2 | Plppr1 | Phospholipid phosphatase-related protein type 1 | Rattus norvegicus (Rat) | PR |
| A4II83 | plppr1 | Phospholipid phosphatase-related protein type 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASDNTHRSY | SIIPCFIFVE | LVIMAGTVLL | AYYFECTDTF | GIHIQGFFCN | DADLLKPYPG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PEESSFIQPL | ILYCVVAAAP | TAIIFVGEIS | MYIMKSTGEA | LLAQEKTIVT | GECCYLNPLI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RRIIRFIGVF | AFGLFATDIF | VNAGQVVTGN | LAPYFLNVCK | PNYTGLDCHF | SHQFIANGNI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CTGNQVVVER | ARRSFPSKDA | SLSVYSAVYV | TMYITSTIKT | KSSRLAKPVL | CLGLLCAAFL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TGLNRVSEYR | NHCSDVVAGF | ILGSSIALFL | GICVVNNFKG | THSTPTKQKQ | EDYRGLPLMT |
| 310 | 320 | 330 | |||
| FPRVESPLET | LSAQGKSCQA | TLLTSSQPNT | WSA |