AiPD: Autoinhibited Protein Database

Q8TAL6

Gene name	FIBIN (PSEC0235)
Protein name	Fin bud initiation factor homolog
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:387758
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

96-178 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

96-178 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8TAL6

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8TAL6-F1	Predicted				AlphaFoldDB

181 variants for Q8TAL6

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	3	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5927303 rs748484153	4	L>R		No	ClinGen ExAC gnomAD
rs768707994 CA5927304	5	K>E		No	ClinGen ExAC TOPMed gnomAD
CA5927305 rs530728345	5	K>R		No	ClinGen 1000Genomes ExAC gnomAD
CA219795607 rs991938715 COSM1353308	6	F>L	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA5927306 COSM1353308 rs748025002	6	F>L	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA5927307 rs182155914	6	F>S		No	ClinGen 1000Genomes ExAC gnomAD
rs773033909 CA5927308	7	F>L		No	ClinGen ExAC gnomAD
rs762631076 CA5927309	8	C>G		No	ClinGen ExAC TOPMed gnomAD
rs370374525 CA5927310	10	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA5927311 rs774059740	10	S>N		No	ClinGen ExAC gnomAD
CA380069495 rs1374531233 COSM3791421	10	S>R	urinary_tract [Cosmic]	No	ClinGen cosmic curated gnomAD
rs758962311 CA5927312	13	C>S		No	ClinGen ExAC
rs768105203 CA5927313	13	C>W		No	ClinGen ExAC gnomAD
CA219795608 rs917728784	15	L>Q		No	ClinGen TOPMed
rs753119016 CA5927314	16	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA5927315 rs761122473	21	D>H		No	ClinGen ExAC TOPMed gnomAD
rs764326535 CA5927316	22	G>V		No	ClinGen ExAC TOPMed gnomAD
CA380069585 rs1438932678	24	L>F		No	ClinGen TOPMed gnomAD
CA380069586 rs1438932678	24	L>I		No	ClinGen TOPMed gnomAD
CA380069590 rs1298028331	24	L>R		No	ClinGen gnomAD
CA5927317 rs148609591	26	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1234369679 CA380069639	31	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA5927320 rs750543782	31	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1182192465 CA380069642	32	T>S		No	ClinGen TOPMed
CA5927321 rs758386807	33	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1215263183 CA380069654	34	H>L		No	ClinGen TOPMed gnomAD
rs889567603 CA219795612	34	H>N		No	ClinGen TOPMed gnomAD
CA380069651 rs889567603	34	H>Y		No	ClinGen TOPMed gnomAD
rs1263411419 CA380069663	35	H>Q		No	ClinGen gnomAD
CA380069659 rs1221687056	35	H>Y		No	ClinGen TOPMed
CA380069681 rs1489100965	38	V>M		No	ClinGen TOPMed gnomAD
CA380069694 rs1407363408	40	D>G		No	ClinGen TOPMed
rs144159497 CA5927324	40	D>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs144159497 CA5927325	40	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs749074974 CA5927326	41	G>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA5927329 rs745429492	42	D>N		No	ClinGen ExAC
rs1393770103 CA380069742	46	N>K		No	ClinGen gnomAD
rs1039031363 CA219795614	47	D>A		No	ClinGen Ensembl
CA5927330 rs771433235	47	D>N		No	ClinGen ExAC TOPMed gnomAD
rs776093770 CA5927331	49	P>L		No	ClinGen ExAC gnomAD
rs1590142149 CA380069759	49	P>S		No	ClinGen Ensembl
TCGA novel	50	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA380069771 rs1357791047	51	K>E		No	ClinGen gnomAD
rs777047715 CA5927334	52	C>G		No	ClinGen ExAC gnomAD
rs1236128909 CA380069780	52	C>Y		No	ClinGen gnomAD
rs147357826 CA5927335	55	L>F		No	ClinGen ESP ExAC gnomAD
CA219795615 rs1016614965	57	R>G		No	ClinGen TOPMed gnomAD
rs1472695326 CA380069837 COSM687638	60	D>E	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1262040869 CA380069840	61	H>D		No	ClinGen TOPMed gnomAD
CA5927336 rs534952472	62	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1204228943 CA380069853	63	R>S		No	ClinGen gnomAD
rs1259353076 CA380069859	64	C>S		No	ClinGen gnomAD
CA380069862 rs1476079164	64	C>Y		No	ClinGen TOPMed gnomAD
rs758538918 CA5927338	65	S>F		No	ClinGen ExAC gnomAD
rs766304964 CA380069880 CA5927339	67	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC TOPMed gnomAD NCI-TCGA
rs766304964 CA380069881	67	G>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	68	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA380069885 rs1564936763	68	E>K		No	ClinGen Ensembl
rs1026568009 CA219795616	69	G>R		No	ClinGen TOPMed
CA5927340 rs752698247	70	S>N		No	ClinGen ExAC gnomAD
CA5927341 rs374082701	71	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1415782806 CA380069918	73	G>S		No	ClinGen gnomAD
rs1437836470 CA380069931	74	S>R		No	ClinGen TOPMed gnomAD
rs1323263193 CA380069939	76	L>Q		No	ClinGen TOPMed
rs1590142196 CA380069945	77	S>N		No	ClinGen Ensembl
CA5927342 rs777845620	79	T>A		No	ClinGen ExAC gnomAD
rs749131148 CA5927343	80	L>V		No	ClinGen ExAC TOPMed gnomAD
rs567988004 CA5927344	81	R>P		No	ClinGen 1000Genomes ExAC gnomAD
rs886584234 CA219795618	81	R>W		No	ClinGen Ensembl
rs879086906 CA219795619	82	E>K		No	ClinGen Ensembl
CA219795620 rs879086906	82	E>Q		No	ClinGen Ensembl
CA5927347 rs745468474	83	E>V		No	ClinGen ExAC
CA380070013 rs1381123498	89	R>C		No	ClinGen gnomAD
CA380070043 rs1564936802	93	D>G		No	ClinGen Ensembl
CA5927350 rs746514366	94	A>V		No	ClinGen ExAC gnomAD
rs769192062 CA5927351	95	G>V		No	ClinGen ExAC gnomAD
CA219795622 rs927935181	96	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs138273386 CA5927353	96	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5927354 rs138273386	96	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs188656817 CA5927355	97	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA380070067 rs1157105343	98	L>V		No	ClinGen gnomAD
CA380070072 rs1397109183	99	E>Q		No	ClinGen gnomAD
rs151294474 CA219795623	100	G>S		No	ClinGen ESP TOPMed
rs1173384319 CA380070106	102	S>N		No	ClinGen gnomAD
TCGA novel	102	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763032340 CA5927356	104	S>G		No	ClinGen ExAC
CA380070135 rs1374071090	104	S>N		No	ClinGen gnomAD
rs1299265949 CA380070184	108	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA5927358 rs751653174	110	D>A		No	ClinGen ExAC gnomAD
rs764174247 CA5927360	111	G>E		No	ClinGen ExAC TOPMed gnomAD
CA5927359 rs140574615	111	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5927362 rs149580940	113	E>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA380070271 rs1233388500	114	S>N		No	ClinGen gnomAD
TCGA novel	116	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750103673 CA5927364	118	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs746550163 CA380070351	120	R>L		No	ClinGen ExAC TOPMed gnomAD
rs746550163 CA5927367	120	R>P		No	ClinGen ExAC TOPMed gnomAD
rs779727131 CA5927366	120	R>W		No	ClinGen ExAC gnomAD
rs902469109 CA219795627	121	R>Q		No	ClinGen TOPMed gnomAD
rs1590142292 CA380070369	122	E>G		No	ClinGen Ensembl
CA5927368 rs768108138	122	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1590142294 CA380070381	123	S>A		No	ClinGen Ensembl
rs1590142298 CA380070395	124	H>P		No	ClinGen Ensembl
CA380070391 rs1295419408	124	H>Y		No	ClinGen TOPMed
CA5927369 rs781688110	125	Q>E		No	ClinGen ExAC gnomAD
CA5927370 rs141428961	125	Q>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5927371 rs770159379	126	I>L		No	ClinGen ExAC
rs1328648033 CA380070431	126	I>M		No	ClinGen TOPMed gnomAD
rs1441121207 CA380070437	127	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA5927372 CA5927373 rs372777320	127	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs774606887 CA5927375	128	D>H		No	ClinGen ExAC TOPMed gnomAD
CA5927376 rs759709640	130	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs936582341 CA219795628	130	Y>H		No	ClinGen TOPMed gnomAD
CA5927377 rs767662457	131	S>T		No	ClinGen ExAC gnomAD
rs1468985777 CA380070506	132	N>K		No	ClinGen gnomAD
rs540597862 CA5927379	132	N>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1213240103 CA380070517	133	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs975092793 CA380070535 CA380070533	134	D>E		No	ClinGen TOPMed gnomAD
rs765208032 CA5927380	136	S>P		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	139	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5927383 rs200720522	143	K>R		No	ClinGen 1000Genomes ExAC gnomAD
CA5927385 rs199736217	144	F>I		No	ClinGen ExAC gnomAD
rs780626122 CA5927387	145	K>N		No	ClinGen ExAC gnomAD
rs754490539 CA5927386	145	K>Q		No	ClinGen ExAC gnomAD
rs747647368 CA5927388	146	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs767097250 CA5927389	147	G>D		No	ClinGen ExAC TOPMed gnomAD
CA380070667 rs1216674774	147	G>R		No	ClinGen TOPMed gnomAD
rs1216674774 CA380070666	147	G>S		No	ClinGen TOPMed gnomAD
CA5927392 rs144294030	152	S>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA219795630 rs367758269	153	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
rs759764078 CA5927394	153	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1190611118 CA380070713	154	Q>K		No	ClinGen gnomAD
rs562967725 CA5927396	154	Q>P		No	ClinGen 1000Genomes ExAC gnomAD
CA380070741 rs1475198378	157	R>S		No	ClinGen gnomAD
CA380070746 rs1380682783	158	L>P		No	ClinGen TOPMed
CA5927397 rs185352306	158	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1402047889 CA380070749	159	N>D		No	ClinGen gnomAD
CA5927399 rs773153187	159	N>K		No	ClinGen ExAC gnomAD
CA380070757 rs1344331770	160	E>*		No	ClinGen TOPMed gnomAD
TCGA novel	160	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA380070755 rs1344331770	160	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA380070764 rs1372343654	161	D>N		No	ClinGen TOPMed
CA5927401 rs552386801	162	F>L		No	ClinGen 1000Genomes ExAC gnomAD
CA5927402 rs751228544	165	M>I		No	ClinGen ExAC gnomAD
rs754685334 CA5927403	167	V>F		No	ClinGen ExAC gnomAD
rs767157136 CA5927404	169	T>S		No	ClinGen ExAC gnomAD
CA380070823 rs1424729982	170	R>T		No	ClinGen TOPMed gnomAD
rs1564936938 CA380070832	171	S>C		No	ClinGen Ensembl
rs1463350210 CA380070840	173	L>M		No	ClinGen TOPMed
CA219795631 rs1026887967	175	E>Q		No	ClinGen TOPMed gnomAD
CA380070866 rs1590142428	177	L>V		No	ClinGen Ensembl
CA219795632 rs951023604	178	D>E		No	ClinGen TOPMed
CA380070870 rs1283830764	178	D>H		No	ClinGen TOPMed gnomAD
rs199891167 CA5927405	180	S>P		No	ClinGen ExAC gnomAD
CA380070884 rs199891167	180	S>T		No	ClinGen ExAC gnomAD
CA219795633 rs982755783	181	V>L		No	ClinGen TOPMed
rs1590142446 CA380070901	183	L>F		No	ClinGen Ensembl
CA380070930 rs1485611409	187	Y>H		No	ClinGen gnomAD
CA5927406 rs755624469	188	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA380070944 rs1235193750	189	L>M		No	ClinGen TOPMed gnomAD
rs1051766285 CA219795634	194	I>V		No	ClinGen Ensembl
CA380070980 rs1330574512	195	R>K		No	ClinGen TOPMed
TCGA novel	195	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5927407 rs778160750	196	S>N		No	ClinGen ExAC gnomAD
CA5927408 rs749760727	198	G>R		No	ClinGen ExAC gnomAD
rs564302767 CA5927409	199	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA380071011 COSM926111 rs1375880929	200	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA5927411 rs779278112	200	R>P		No	ClinGen ExAC gnomAD
rs779278112 CA5927410	200	R>Q		No	ClinGen ExAC gnomAD
rs747108753 CA5927414	203	R>Q		No	ClinGen ExAC gnomAD
CA5927416 rs773030136	207	D>A		No	ClinGen ExAC TOPMed gnomAD
rs1279094258 CA380071051	207	D>Y		No	ClinGen gnomAD
rs762892337 CA380071060	208	Y>C		No	ClinGen ExAC gnomAD
rs762892337 CA5927417	208	Y>F		No	ClinGen ExAC gnomAD
rs1246951384 CA380071057	208	Y>H		No	ClinGen TOPMed
CA219795636 rs546595652	210	K>E		No	ClinGen 1000Genomes TOPMed
CA380071074 rs1281440983	210	K>N		No	ClinGen gnomAD
rs546595652 CA380071069	210	K>Q		No	ClinGen 1000Genomes TOPMed
rs766216934 CA5927418	211	V>I		No	ClinGen ExAC TOPMed gnomAD
rs140603082 CA380071088	212	V>Y		No	ClinGen ESP ExAC TOPMed gnomAD

No associated diseases with Q8TAL6

No regional properties for Q8TAL6

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q8TAL6

Functions

		Description
EC Number
Subcellular Localization	Secreted Golgi apparatus Endoplasmic reticulum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.

1 GO annotations of molecular function

Name	Definition
protein homodimerization activity	Binding to an identical protein to form a homodimer.

3 GO annotations of biological process

Name	Definition
protein kinase C signaling	A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
response to dexamethasone	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.
response to manganese ion	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5E9H1	FIBIN	Fin bud initiation factor homolog	Bos taurus (Bovine)	PR
A4UZ23	FIBIN	Fin bud initiation factor homolog	Equus caballus (Horse)	PR
Q9CQS3	Fibin	Fin bud initiation factor homolog	Mus musculus (Mouse)	PR
A1IGX5	fibin	Fin bud initiation factor	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MVFLKFFCMS	FFCHLCQGYF	DGPLYPEMSN	GTLHHYFVPD	GDYEENDDPE	KCQLLFRVSD
70	80	90	100	110	120
HRRCSQGEGS	QVGSLLSLTL	REEFTVLGRQ	VEDAGRVLEG	ISKSISYDLD	GEESYGKYLR
130	140	150	160	170	180
RESHQIGDAY	SNSDKSLTEL	ESKFKQGQEQ	DSRQESRLNE	DFLGMLVHTR	SLLKETLDIS
190	200	210
VGLRDKYELL	ALTIRSHGTR	LGRLKNDYLK	V