Q8SY96

PR
Gene name
CG32500; (CG32857;, CG33502)
Protein name
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
Names
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG33502
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-75 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8SY96

Entry ID Method Resolution Chain Position Source
AF-Q8SY96-F1 Predicted AlphaFoldDB

No variants for Q8SY96

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8SY96

No associated diseases with Q8SY96

3 regional properties for Q8SY96

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 250 - 258 IPR000629
domain NIF system FeS cluster assembly, NifU, C-terminal 182 - 248 IPR001075
domain Scaffold protein Nfu/NifU, N-terminal 69 - 156 IPR014824

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
iron ion binding Binding to an iron (Fe) ion.

2 GO annotations of biological process

Name Definition
iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
protein maturation by iron-sulfur cluster transfer The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32860 NFU1 NifU-like protein, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q8SY96 CG32500; NFU1 iron-sulfur cluster scaffold homolog, mitochondrial Drosophila melanogaster (Fruit fly) PR
Q9UMS0 NFU1 NFU1 iron-sulfur cluster scaffold homolog, mitochondrial Homo sapiens (Human) PR
Q9QZ23 Nfu1 NFU1 iron-sulfur cluster scaffold homolog, mitochondrial Mus musculus (Mouse) PR
10 20 30 40 50 60
MSKFLSQAAL NTLRNTRLGS RQLVRSFKGI SNTRNHRIPA HQESGCGHSV GCGLLELRMP
70 80 90 100 110 120
VACRRSMFIQ TQDTPNPESL KFLPGVDVLG KGNTYDFPNG TTAHNSPLAK LLFRVEGVKG
130 140 150 160 170 180
VFFGADFVTI SKQEGAEWSL IKPEVFAVIM DFFASGLPVL NDAQPNADTE ILEDDDETVM
190 200 210 220 230 240
MIKELLDTRI RPTVQEDGGD IVFMGYEGGV VKLKMQGSCS SCPSSIVTLK NGVQNMLQFY
250 260 270 280
IPEVESVEQV FDEADRMIES EFERFEKNLK TLKQQEPSGG GPH