Q9QZ23
Gene name |
Nfu1 (Hirip5) |
Protein name |
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial |
Names |
C-type lectin superfamily member 6, Dendritic cell immunoreceptor, HIRA-interacting protein 5, mHIRIP5 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:56748 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q9QZ23
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1VEH | NMR | - | A | 163-241 | PDB |
| AF-Q9QZ23-F1 | Predicted | AlphaFoldDB |
11 variants for Q9QZ23
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs36338602 | 15 | V>A | No | EVA | |
| rs3388841988 | 21 | F>I | No | EVA | |
| rs3388844963 | 31 | K>* | No | EVA | |
| rs3388842039 | 32 | K>* | No | EVA | |
| rs13470135 | 39 | V>A | No | EVA | |
| rs228826157 | 45 | P>L | No | EVA | |
| rs3388827970 | 109 | S>N | No | EVA | |
| rs3388842395 | 137 | A>D | No | EVA | |
| rs242749361 | 156 | P>L | No | EVA | |
| rs3388841985 | 164 | E>D | No | EVA | |
| rs3388846707 | 222 | S>I | No | EVA |
No associated diseases with Q9QZ23
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| 4 iron, 4 sulfur cluster binding | Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| iron ion binding | Binding to an iron (Fe) ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| iron-sulfur cluster assembly | The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. |
| protein maturation by iron-sulfur cluster transfer | The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32860 | NFU1 | NifU-like protein, mitochondrial | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q8SY96 | CG32500; | NFU1 iron-sulfur cluster scaffold homolog, mitochondrial | Drosophila melanogaster (Fruit fly) | PR |
| Q9UMS0 | NFU1 | NFU1 iron-sulfur cluster scaffold homolog, mitochondrial | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAAERAWGA | AVGVVRLCRR | FCHVATPHTF | KKQPLHQYVR | RPLFPLRAPL | CNTVRFMFIQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TQDTPNPNSL | KFIPGKPVLE | TRTMDFPTPA | AAFRSPLARQ | LFRIEGVKSV | FFGPDFITVT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KENEELDWNL | LKPDIYATIM | DFFASGLPLV | TEETPPPPGE | AGSEEDDEVV | AMIKELLDTR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IRPTVQEDGG | DVIYRGFEDG | IVRLKLQGSC | TSCPSSIITL | KSGIQNMLQF | YIPEVEGVEQ |
| 250 | |||||
| VMDDDESDEK | EANSS |