P32860
Gene name |
NFU1 (NUB1, YKL040C, YKL253) |
Protein name |
NifU-like protein, mitochondrial |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YKL040C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P32860
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2LTL | NMR | - | A | 17-124 | PDB |
| AF-P32860-F1 | Predicted | AlphaFoldDB |
9 variants for P32860
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s11-361456 | 6 | A>P | No | SGRP | |
| s11-361456 | 6 | A>T | No | SGRP | |
| s11-361455 | 6 | A>V | No | SGRP | |
| s11-361443 | 10 | K>R | No | SGRP | |
| s11-361441 | 11 | S>P | No | SGRP | |
| s11-361417 | 19 | Q>K | No | SGRP | |
| s11-361125 | 116 | Y>C | No | SGRP | |
| s11-361095 | 126 | H>R | No | SGRP | |
| s11-361033 | 147 | T>S | No | SGRP |
No associated diseases with P32860
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| 4 iron, 4 sulfur cluster binding | Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| iron ion binding | Binding to an iron (Fe) ion. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular sequestering of iron ion | The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system. |
| iron-sulfur cluster assembly | The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. |
| protein maturation by [4Fe-4S] cluster transfer | The transfer of an assembled 4Fe-4S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein. |
| protein maturation by iron-sulfur cluster transfer | The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8SY96 | CG32500; | NFU1 iron-sulfur cluster scaffold homolog, mitochondrial | Drosophila melanogaster (Fruit fly) | PR |
| Q9UMS0 | NFU1 | NFU1 iron-sulfur cluster scaffold homolog, mitochondrial | Homo sapiens (Human) | PR |
| Q9QZ23 | Nfu1 | NFU1 iron-sulfur cluster scaffold homolog, mitochondrial | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFKSVAKLGK | SPIFYLNSQR | LIHIKTLTTP | NENALKFLST | DGEMLQTRGS | KSIVIKNTDE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NLINHSKLAQ | QIFLQCPGVE | SLMIGDDFLT | INKDRMVHWN | SIKPEIIDLL | TKQLAYGEDV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ISKEFHAVQE | EEGEGGYKIN | MPKFELTEED | EEVSELIEEL | IDTRIRPAIL | EDGGDIDYRG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WDPKTGTVYL | RLQGACTSCS | SSEVTLKYGI | ESMLKHYVDE | VKEVIQIMDP | EQEIALKEFD |
| 250 | |||||
| KLEKKLESSK | NTSHEK |