Q8R1R3
Gene name |
Stard7 |
Protein name |
StAR-related lipid transfer protein 7, mitochondrial |
Names |
START domain-containing protein 7, StARD7 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:99138 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8R1R3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8R1R3-F1 | Predicted | AlphaFoldDB |
11 variants for Q8R1R3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388593053 | 76 | S>F | No | EVA | |
| rs3388587567 | 114 | I>K | No | EVA | |
| rs33279719 | 123 | Y>H | No | EVA | |
| rs3388587519 | 130 | P>S | No | EVA | |
| rs3388593045 | 139 | D>N | No | EVA | |
| rs27434127 | 158 | R>H | No | EVA | |
| rs3388587238 | 162 | G>S | No | EVA | |
| rs3388593071 | 212 | G>D | No | EVA | |
| rs3388593070 | 235 | R>L | No | EVA | |
| rs3392047642 | 351 | K>* | No | EVA | |
| rs3392105537 | 351 | K>M | No | EVA |
No associated diseases with Q8R1R3
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| lipid binding | Binding to a lipid. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| establishment of skin barrier | Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability. |
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| mucociliary clearance | The respiratory system process driven by motile cilia on epithelial cells of the respiratory tract by which mucus and associated inhaled particles and pathogens trapped within it are moved out of the airways. |
| myeloid dendritic cell activation | The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. |
| type 2 immune response | An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9Y365 | STARD10 | START domain-containing protein 10 | Homo sapiens (Human) | PR |
| Q9NQZ5 | STARD7 | StAR-related lipid transfer protein 7, mitochondrial | Homo sapiens (Human) | PR |
| Q9JMD3 | Stard10 | START domain-containing protein 10 | Mus musculus (Mouse) | PR |
| Q9EQG9 | Cert1 | Ceramide transfer protein | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFPRRPPATL | AAWLAGARGG | GLLSALANQC | RFVTGLRVRR | AQQIAQLYGR | LYSESSRCAL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LGRFWRRLRG | RPGHASVLMA | ALSGVFVWDE | ERIQEEELQR | SINEMKRLEE | MSNIFQSSGV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ENYPPEPKSP | AGGNEKSKDK | EEPWEMVMDK | KHFKLWRRPI | TGTHLYQYRV | FGTYTDVTPR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QFFNVQLDTE | YRKKWDALVI | KLEVIERDAV | SGSEVLHWVT | HFPYPMYSRD | YVYVRRYSVD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QENNVMVLVS | RAVEHPSVPE | SPEFVRVRSY | ESQMVIRPHK | SFDENGFDYL | LTYSDNPQTV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FPRYCVSWMV | SSGMPDFLEK | LHMATLKAKN | MEIKVKDYIS | AKPLEMSSEA | KATAPSPERK |
| 370 | |||||
| NEGSCGPARI | EYA |