AiPD: Autoinhibited Protein Database

Q9NQZ5

Gene name	STARD7 (GTT1)
Protein name	StAR-related lipid transfer protein 7, mitochondrial
Names	Gestational trophoblastic tumor protein 1, START domain-containing protein 7, StARD7
Species	Homo sapiens (Human)
KEGG Pathway	hsa:56910
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

64-166 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

64-166 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9NQZ5

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9NQZ5-F1	Predicted				AlphaFoldDB

337 variants for Q9NQZ5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs941229827 CA52381208	2	L>P		No	ClinGen TOPMed
rs755043599 CA52381210	2	L>V		No	ClinGen Ensembl
rs1429338289 CA347643384	3	P>L		No	ClinGen gnomAD
CA347643373 rs1573950118	4	R>Q		No	ClinGen Ensembl
rs1337801102 CA347643376	4	R>W		No	ClinGen gnomAD
CA347643359 rs1273708351	6	L>P		No	ClinGen TOPMed
rs984791705 CA52381188	7	L>P		No	ClinGen Ensembl
rs909829606 CA52381201	7	L>V		No	ClinGen Ensembl
rs1415353059 CA347643352	8	A>S		No	ClinGen gnomAD
CA347643346 rs1211767993	8	A>V		No	ClinGen TOPMed
rs769162359 CA1777152	9	A>P		No	ClinGen ExAC TOPMed
rs769162359 CA347643342	9	A>T		No	ClinGen ExAC TOPMed
CA1777150 rs200913103	10	W>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs992620110 CA52381159	12	A>P		No	ClinGen TOPMed gnomAD
rs992620110 CA347643300	12	A>T		No	ClinGen TOPMed gnomAD
CA347643280 rs1259739039	13	G>A		No	ClinGen gnomAD
rs1476848940 CA347643286	13	G>R		No	ClinGen gnomAD
rs1553433177 CA347643269	14	T>K		No	ClinGen Ensembl
rs1553433177 CA347643267	14	T>R		No	ClinGen Ensembl
CA347643274 rs1408067953	14	T>S		No	ClinGen TOPMed gnomAD
rs1188799731 CA347643259	15	R>Q		No	ClinGen gnomAD
CA1777148 rs746814222	16	G>A		No	ClinGen ExAC gnomAD
rs955275229 CA52381143	16	G>S		No	ClinGen TOPMed
rs999675309 CA347643233	17	G>E		No	ClinGen TOPMed
rs1031106814 CA347643236	17	G>R		No	ClinGen gnomAD
rs999675309 CA52381123	17	G>V		No	ClinGen TOPMed
CA52381131 rs1031106814	17	G>W		No	ClinGen gnomAD
CA347643224 rs1465900421	18	G>C		No	ClinGen TOPMed gnomAD
rs1273202753 CA347643220	18	G>D		No	ClinGen gnomAD
CA347643226 rs1465900421	18	G>R		No	ClinGen TOPMed gnomAD
rs748351378 CA1777144	20	L>P		No	ClinGen ExAC TOPMed gnomAD
CA347643185 rs1354724716	21	A>G		No	ClinGen TOPMed gnomAD
CA1777143 rs755001755	21	A>S		No	ClinGen ExAC gnomAD
rs755001755 CA1777142	21	A>T		No	ClinGen ExAC gnomAD
rs1179213657 CA347643171	22	L>R		No	ClinGen gnomAD
CA347643161 rs1470553965	23	L>P		No	ClinGen gnomAD
rs780433203 CA1777140	24	A>G		No	ClinGen ExAC gnomAD
rs1484987144 CA347643154	24	A>P		No	ClinGen TOPMed
CA347643119 rs1258228355	26	Q>H		No	ClinGen TOPMed
CA1777138 rs201289448	26	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA52381075 rs988324879	27	C>F		No	ClinGen TOPMed
TCGA novel	27	C>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs988324879 CA347643114	27	C>Y		No	ClinGen TOPMed
rs1186405547 CA347643108	28	R>C		No	ClinGen TOPMed
CA347643107 rs1420358503	28	R>H		No	ClinGen gnomAD
CA347643106 rs1420358503	28	R>L		No	ClinGen gnomAD
rs767834090 CA1777137	29	F>L		No	ClinGen ExAC gnomAD
rs1412178891 CA347643098	29	F>L		No	ClinGen TOPMed gnomAD
CA347643101 rs1474961183	29	F>S		No	ClinGen gnomAD
TCGA novel	30	V>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs889415053 CA347643088	31	T>K		No	ClinGen gnomAD
rs889415053 CA52381073	31	T>M		No	ClinGen gnomAD
CA347643084 rs1573949926	32	G>C		No	ClinGen Ensembl
CA1777136 rs762640108	32	G>V		No	ClinGen ExAC gnomAD
CA347643081 rs1031820620	33	L>M		No	ClinGen TOPMed gnomAD
CA347643068 rs1252288620	35	V>A		No	ClinGen gnomAD
CA1777132 rs776148826 CA1777133	35	V>L		No	ClinGen ExAC gnomAD
rs770797331 CA1777131	36	R>W		No	ClinGen ExAC gnomAD
rs760650619 CA1777130	37	R>G		No	ClinGen ExAC gnomAD
CA1777129 rs773182899	38	A>V		No	ClinGen ExAC TOPMed gnomAD
CA1777128 rs748441449	39	Q>L		No	ClinGen ExAC TOPMed gnomAD
CA1777127 rs748441449	39	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1278713578 CA347643046	40	Q>*		No	ClinGen gnomAD
rs774434882 CA1777126	40	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs768859533 CA347643033	41	I>M		No	ClinGen ExAC gnomAD
CA347643031 rs1374032461	42	A>P		No	ClinGen TOPMed
CA1777124 rs369373844	43	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs1304546530 CA347643017	44	L>F		No	ClinGen TOPMed
rs1161858681 CA347643007	45	Y>*		No	ClinGen TOPMed gnomAD
TCGA novel	45	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756650553 CA347643004	46	G>C		No	ClinGen ExAC gnomAD
CA1777121 rs756650553	46	G>S		No	ClinGen ExAC gnomAD
rs746349285 CA1777120	47	R>C		No	ClinGen ExAC gnomAD
CA1777119 rs781592450	47	R>H		No	ClinGen ExAC TOPMed gnomAD
rs746349285 CA347642999	47	R>S		No	ClinGen ExAC gnomAD
rs933705162 CA52380882	48	L>F		No	ClinGen TOPMed gnomAD
rs933705162 CA347642995	48	L>V		No	ClinGen TOPMed gnomAD
rs757612615 CA1777118	49	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1487845912 CA347642990	49	Y>H		No	ClinGen gnomAD
rs764810546 CA1777116	50	S>P		No	ClinGen ExAC TOPMed gnomAD
CA347642975 rs1441305286	51	E>D		No	ClinGen TOPMed
TCGA novel	51	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA52380790 rs753321107	51	E>K		No	ClinGen ExAC TOPMed gnomAD
CA1777114 rs753321107	51	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA347642970 rs1558739101	52	S>N		No	ClinGen Ensembl
CA347642967 rs375475304 CA1777113	52	S>R		No	ClinGen ESP ExAC TOPMed
CA52380781 rs941198705	53	S>*		No	ClinGen Ensembl
rs773271351 CA347642958	54	R>H		No	ClinGen ExAC gnomAD
rs773271351 CA1777111	54	R>P		No	ClinGen ExAC gnomAD
rs767489044 CA1777110	55	R>C		No	ClinGen ExAC gnomAD
rs767489044 CA347642955	55	R>G		No	ClinGen ExAC gnomAD
rs375153536 CA1777109	55	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1290690429 CA347642951	56	V>I		No	ClinGen gnomAD
rs1345113584 CA347642939	58	L>V		No	ClinGen gnomAD
CA347642933 rs1436909374	59	G>R		No	ClinGen gnomAD
rs775814267 CA1777105	60	R>L		No	ClinGen ExAC gnomAD
rs770302206 CA1777104	61	L>F		No	ClinGen ExAC TOPMed gnomAD
rs770302206 CA347642520	61	L>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	62	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347642487 rs1377447530	62	W>C		No	ClinGen TOPMed gnomAD
rs1485910267 CA347642481	63	R>C		No	ClinGen gnomAD
CA347642476 rs1339167636	63	R>P		No	ClinGen TOPMed gnomAD
rs757387212 CA1777100	64	R>G		No	ClinGen ExAC gnomAD
CA1777098 rs11539222	64	R>P		No	ClinGen 1000Genomes ESP TOPMed
rs778095890 CA1777097	66	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA347642436 rs1232329201	66	H>R		No	ClinGen gnomAD
CA347642441 rs1194697594	66	H>Y		No	ClinGen TOPMed
rs554052175 CA1777095	67	G>C		No	ClinGen 1000Genomes ExAC gnomAD
CA1777093 rs766358681	68	R>G		No	ClinGen ExAC TOPMed gnomAD
CA347642410 rs756123503	68	R>H		No	ClinGen ExAC TOPMed gnomAD
CA1777092 rs756123503	68	R>P		No	ClinGen ExAC TOPMed gnomAD
rs766358681 CA347642416	68	R>S		No	ClinGen ExAC TOPMed gnomAD
rs145045733 CA1777090	69	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs145045733 CA1777091	69	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA347642384 rs1573949618	70	G>V		No	ClinGen Ensembl
rs773839860 CA1777088	71	H>Q		No	ClinGen ExAC
CA1777089 rs761430971	71	H>R		No	ClinGen ExAC TOPMed gnomAD
rs763832768 CA1777087	72	A>T		No	ClinGen ExAC gnomAD
rs1375500267 CA347642361	72	A>V		No	ClinGen TOPMed gnomAD
CA347642344 rs1261871251	74	A>G		No	ClinGen TOPMed gnomAD
CA1777086 rs575047234	74	A>S		No	ClinGen 1000Genomes ExAC gnomAD
CA1777085 rs575047234	74	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA347642340 rs1261871251	74	A>V		No	ClinGen TOPMed gnomAD
rs1486600752 CA347642316	76	M>T		No	ClinGen TOPMed gnomAD
rs1258211734 CA347642294	78	A>P		No	ClinGen gnomAD
rs1199660666 CA347642287	78	A>V		No	ClinGen gnomAD
rs1253235783 CA347642260	80	A>V		No	ClinGen gnomAD
CA1777083 rs770212436	83	F>Y		No	ClinGen ExAC gnomAD
rs992193468 CA52380621	84	V>L		No	ClinGen TOPMed gnomAD
CA347642197 rs1272162335	85	W>C		No	ClinGen TOPMed
rs1276352294 CA347642207	85	W>G		No	ClinGen gnomAD
rs1235277997 CA347642180	86	D>E		No	ClinGen TOPMed gnomAD
rs1214129859 CA347642176	87	E>K		No	ClinGen TOPMed
rs1356655624 CA347642158	88	E>*		No	ClinGen gnomAD
CA347642157 rs1573949554	88	E>G		No	ClinGen Ensembl
rs866418925 CA52380615	89	R>G		No	ClinGen Ensembl
rs1337520039 CA347642119	91	Q>*		No	ClinGen TOPMed
CA347642104 rs1214895693	92	E>K		No	ClinGen TOPMed
CA347642003 rs1394591610	96	Q>E		No	ClinGen gnomAD
TCGA novel	98	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs970065647 CA52408224	99	I>V		No	ClinGen TOPMed gnomAD
CA1777054 rs374141714	100	N>S		No	ClinGen ESP ExAC gnomAD
rs1353450405 CA347655576	101	E>K		No	ClinGen gnomAD
CA347655546 rs1261897304	102	M>T		No	ClinGen gnomAD
CA347655498 rs1244137302	104	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA1777053 rs769676604	104	R>W		No	ClinGen ExAC TOPMed gnomAD
CA347655426 rs1306572301	107	E>D		No	ClinGen TOPMed gnomAD
TCGA novel	108	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1777052 rs200122639	108	M>T		No	ClinGen 1000Genomes ExAC gnomAD
CA1777051 rs781221907	110	N>D		No	ClinGen ExAC gnomAD
CA52408212 rs989128326	111	M>I		No	ClinGen TOPMed
CA1777050 rs757227217	111	M>T		No	ClinGen ExAC TOPMed gnomAD
CA1777048 rs777325321	113	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA1777049 rs751521477	113	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs550294070 CA1777047	118	Q>E		No	ClinGen 1000Genomes ExAC gnomAD
rs764901570 CA1777045	120	H>Y		No	ClinGen ExAC gnomAD
CA1777044 rs200880792	121	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA347655062 rs1364856580	122	P>L		No	ClinGen TOPMed gnomAD
CA1777043 rs754214358	123	E>Q		No	ClinGen ExAC gnomAD
CA347655044 rs1319167523	124	P>S		No	ClinGen gnomAD
TCGA novel	126	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs570567602 CA347654985 CA1777040	127	Q>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1573942429 CA347654988	127	Q>P		No	ClinGen Ensembl
CA347654943 rs1448824044	130	G>E		No	ClinGen gnomAD
rs558165041 CA52408133	130	G>R		No	ClinGen Ensembl
rs762020485 CA1777038	131	N>K		No	ClinGen ExAC TOPMed gnomAD
CA347654922 rs1386513888	131	N>S		No	ClinGen gnomAD
CA1777037 rs774671221	134	S>T		No	ClinGen ExAC gnomAD
rs769017540 CA1777036	136	G>D		No	ClinGen ExAC gnomAD
CA347654834 rs1235539046	136	G>S		No	ClinGen gnomAD
rs141619739 CA52408123	137	K>E		No	ClinGen ESP
rs1573942393 CA347654774	138	E>G		No	ClinGen Ensembl
rs745594929 CA1777035	138	E>Q		No	ClinGen ExAC
CA347654759 rs1289002766	139	Q>*		No	ClinGen gnomAD
rs373055559 CA1777034	139	Q>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA1777033 COSM3426765 rs181733184	140	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA347654732 rs2276650	140	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1777032 rs2276650 VAR_020345	140	R>P		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA52408110 rs181733184	140	R>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA347654659 rs1358599663	144	V>L		No	ClinGen gnomAD
TCGA novel	147	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771200537 CA52408078	149	H>R		No	ClinGen TOPMed gnomAD
rs1171054502 CA347654436	151	K>N		No	ClinGen gnomAD
CA347654441 rs1424647538	151	K>R		No	ClinGen gnomAD
rs754628120 COSM1196655 CA1777027	154	R>L	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA347654365 rs754628120	154	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1193093626 CA347654370	154	R>W		No	ClinGen gnomAD
CA1777026 rs753553383	155	R>C		No	ClinGen ExAC gnomAD
rs561682205 COSM1023853 CA1777025	155	R>H	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs149097861 CA1777024 COSM443383	156	P>S	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA gnomAD
rs767936137 CA1777022	157	I>V		No	ClinGen ExAC TOPMed gnomAD
CA347654289 rs1341083499	158	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA347654253 rs1278250362	158	T>I		No	ClinGen gnomAD
CA347654248 rs1209356910	159	G>S		No	ClinGen gnomAD
rs1338326784 CA347654204	160	T>I		No	ClinGen gnomAD
CA347654175 rs1358388272	162	L>V		No	ClinGen gnomAD
rs774581450 CA1777020	163	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA52408048 rs1027139678	164	Q>L		No	ClinGen TOPMed gnomAD
rs1424670070 CA347654104	165	Y>H		No	ClinGen gnomAD
CA347654085 rs1573942295	166	R>Q		No	ClinGen Ensembl
rs764339918 CA1777019	167	V>F		No	ClinGen ExAC gnomAD
rs757838003 CA1777004	170	T>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	172	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs901830366 CA52407821	173	D>V		No	ClinGen Ensembl
CA1777002 rs764248203	176	P>A		No	ClinGen ExAC gnomAD
rs200450259 CA347653816	177	R>L		No	ClinGen ExAC TOPMed gnomAD
rs200450259 CA347653818	177	R>P		No	ClinGen ExAC TOPMed gnomAD
CA1777000 rs200450259	177	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs369340448 CA1777001	177	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA1776999 rs765401746	181	N>D		No	ClinGen ExAC gnomAD
rs150385509 CA1776998	181	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	183	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347653105 rs1261144366	187	E>G		No	ClinGen TOPMed
rs146539240 CA52406914	188	Y>C		No	ClinGen ESP TOPMed gnomAD
CA347653091 rs1558734624	188	Y>H		No	ClinGen Ensembl
TCGA novel	191	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1419003364 CA347653022	191	K>R		No	ClinGen TOPMed
rs763770998 CA52406892	198	K>N		No	ClinGen TOPMed gnomAD
TCGA novel	200	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs372858958 CA1776976	200	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA1776972 rs768599369	208	S>C		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	208	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1776971 rs762462471	208	S>T		No	ClinGen ExAC
rs1296893030 CA347652725	209	G>D		No	ClinGen gnomAD
CA347652654 rs1222182169	214	H>Y		No	ClinGen TOPMed gnomAD
rs1302673373 CA347652607	217	T>I		No	ClinGen gnomAD
CA1776968 rs368142186	218	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1029515133 CA52406718	221	Y>C		No	ClinGen TOPMed
rs1436103253 CA347652493	222	P>A		No	ClinGen TOPMed
rs764625182 CA1776950	222	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1186578722 CA347652473	223	M>I		No	ClinGen gnomAD
rs1374702843 CA347652482	223	M>V		No	ClinGen TOPMed
rs1240197834 CA347652446	226	R>Q		No	ClinGen TOPMed gnomAD
rs569009343 CA1776948	226	R>W		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	228	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1776947 rs770721007	229	V>L		No	ClinGen ExAC gnomAD
rs144418439 COSM1227750 CA52406701	232	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes gnomAD
CA347652368 rs1211771618	233	R>Q		No	ClinGen TOPMed gnomAD
rs747311185 CA1776946	233	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA347652354 rs1265371387	234	Y>C		No	ClinGen gnomAD
rs200306093 CA52406694	235	S>G		No	ClinGen TOPMed
rs763820103 CA52406680	235	S>N		No	ClinGen gnomAD
CA1776944 rs772545183	235	S>R		No	ClinGen ExAC gnomAD
rs763820103 CA347652336	235	S>T		No	ClinGen gnomAD
rs148778899 CA52406669	242	M>V		No	ClinGen ESP TOPMed gnomAD
CA52406663 rs187160371 CA52406666	243	M>I		No	ClinGen 1000Genomes TOPMed
CA347652208 rs1375758505	243	M>L		No	ClinGen TOPMed gnomAD
CA347652205 rs1375758505	243	M>V		No	ClinGen TOPMed gnomAD
CA347652189 rs748579701	244	V>L		No	ClinGen ExAC TOPMed gnomAD
rs748579701 CA1776943	244	V>M		No	ClinGen ExAC TOPMed gnomAD
CA52406662 rs945442997	245	L>V		No	ClinGen Ensembl
CA1776942 rs779513973 COSM1023847	247	S>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
TCGA novel	248	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347652097 rs1162603886	248	R>H		No	ClinGen gnomAD
rs1002670848 CA52406358	251	E>*		No	ClinGen Ensembl
TCGA novel	251	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1281865022 CA347651758	253	P>L		No	ClinGen TOPMed
CA52406355 rs907045436	253	P>T		No	ClinGen Ensembl
rs774669103 CA1776923	255	V>M		No	ClinGen ExAC gnomAD
rs769915830 CA1776919	261	F>L		No	ClinGen ExAC TOPMed gnomAD
rs746062359 CA1776917	262	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	263	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1223643967 CA347651406	265	R>G		No	ClinGen TOPMed gnomAD
CA347651383 rs1216266195	266	S>T		No	ClinGen TOPMed gnomAD
rs1281640886 CA347651352	267	Y>H		No	ClinGen gnomAD
CA347651169 rs1558734320	271	M>I		No	ClinGen Ensembl
rs1573941080 CA347651210	271	M>T		No	ClinGen Ensembl
rs1010589483 CA52406256	274	R>C		No	ClinGen gnomAD
CA1776914 rs762860851	274	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	275	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA52406238 rs892448829	276	H>Q		No	ClinGen TOPMed
CA1776913 rs778649160	276	H>R		No	ClinGen ExAC TOPMed gnomAD
CA347650992 rs1412064358	277	K>R		No	ClinGen TOPMed
CA347649710 rs1201984076	286	Y>C		No	ClinGen TOPMed
rs369139098 CA1776900	287	L>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs781214291 CA1776899	288	L>P		No	ClinGen ExAC gnomAD
rs1441631365 CA347649691	288	L>V		No	ClinGen TOPMed
CA1776897 rs747263368	289	T>I		No	ClinGen ExAC gnomAD
CA347649670 rs1415931370	290	Y>C		No	ClinGen TOPMed
COSM576412 CA52403282 rs368914673	291	S>I	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP NCI-TCGA TOPMed
rs1159951960 CA347649633	293	N>S		No	ClinGen TOPMed
CA347649610 rs1573938724	295	Q>L		No	ClinGen Ensembl
CA1776896 rs149632619	296	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1776893 rs780170884	297	V>A		No	ClinGen ExAC gnomAD
TCGA novel	297	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347649570 rs1472682102	299	P>S		No	ClinGen gnomAD
CA52403262 rs951200488	300	R>C		No	ClinGen TOPMed gnomAD
COSM1227748 rs138719942 CA1776891	300	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA347649549 rs1238226425	301	Y>C		No	ClinGen TOPMed gnomAD
rs997703035 CA52403252	303	V>F		No	ClinGen TOPMed
rs901967167 CA52403249	304	S>N		No	ClinGen TOPMed gnomAD
rs767009305 CA1776890	305	W>R		No	ClinGen ExAC gnomAD
rs1291946556 CA347649485	307	V>I		No	ClinGen gnomAD
CA1776889 rs141727167	309	S>R		No	ClinGen ESP ExAC
CA52403023 rs143562757	311	M>V		No	ClinGen ESP TOPMed
TCGA novel	313	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1300428336 CA347649316	317	K>E		No	ClinGen gnomAD
rs766449072 CA1776863	317	K>T		No	ClinGen ExAC gnomAD
CA1776862 rs760700979	318	L>P		No	ClinGen ExAC gnomAD
rs773518469 CA1776861 COSM3840275	320	M>V	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs772432796 CA1776860	321	A>T		No	ClinGen ExAC gnomAD
CA1776859 rs749019876	323	L>Q		No	ClinGen ExAC gnomAD
TCGA novel	323	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs868428636 CA52403004	326	K>N		No	ClinGen Ensembl
CA347649227 rs1480063490	327	N>S		No	ClinGen gnomAD
CA347649205 rs1266770379	330	I>F		No	ClinGen gnomAD
CA347649204 rs1266770379	330	I>V		No	ClinGen gnomAD
rs146759739 CA52403000	332	V>L		No	ClinGen ESP
CA1776858 rs775418070	334	D>H		No	ClinGen ExAC gnomAD
CA347649167 rs775418070	334	D>N		No	ClinGen ExAC gnomAD
rs745790648 CA1776856	336	I>M		No	ClinGen ExAC TOPMed gnomAD
CA1776857 rs140563521	336	I>N		No	ClinGen ESP ExAC TOPMed
CA52402958 rs370888124	338	A>V		No	ClinGen ESP TOPMed
CA1776852 rs777341785	343	M>I		No	ClinGen ExAC TOPMed gnomAD
rs200777125 CA1776853	343	M>T		No	ClinGen 1000Genomes ExAC gnomAD
rs570567633 CA1776851	345	S>N		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	346	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765565436 CA1776849	349	A>P		No	ClinGen ExAC gnomAD
CA1776848 rs755336827	350	T>P		No	ClinGen ExAC gnomAD
CA347648929 rs1281452228	354	S>Y		No	ClinGen gnomAD
rs766817394 CA1776846	356	R>Q		No	ClinGen ExAC gnomAD
rs1451153062 CA347648898	357	K>R		No	ClinGen gnomAD
CA347648876 rs1176153785	359	E>K		No	ClinGen gnomAD
rs1313885184 CA347648862	360	G>S		No	ClinGen gnomAD
TCGA novel	364	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1776843 rs767768801	364	P>L		No	ClinGen ExAC gnomAD
rs1195793193 CA347648810	364	P>S		No	ClinGen gnomAD
CA347648799 rs932459835	365	A>G		No	ClinGen TOPMed
rs932459835 CA52402928	365	A>V		No	ClinGen TOPMed
COSM3380254 CA1776840 rs533954441	366	R>Q	pancreas [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs774757302 CA1776841	366	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1203054186 CA347648783	367	I>T		No	ClinGen TOPMed gnomAD
rs1321540562 CA347648771	368	E>G		No	ClinGen gnomAD
CA1776839 rs759275696	369	Y>C		No	ClinGen ExAC gnomAD
CA52402887 rs201771782	370	A>G		No	ClinGen 1000Genomes
rs1326412614 CA347648749	370	A>S		No	ClinGen TOPMed gnomAD
CA52402886 rs201771782	370	A>V		No	ClinGen 1000Genomes

No associated diseases with Q9NQZ5

2 regional properties for Q9NQZ5

Type	Name	Position	InterPro Accession
domain	START domain	121 - 329	IPR002913
domain	STARD7, START domain	117 - 325	IPR041949

Functions

		Description
EC Number
Subcellular Localization	Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
mitochondrial outer membrane	The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.

1 GO annotations of molecular function

Name	Definition
lipid binding	Binding to a lipid.

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9Y365	STARD10	START domain-containing protein 10	Homo sapiens (Human)	PR
Q9JMD3	Stard10	START domain-containing protein 10	Mus musculus (Mouse)	PR
Q8R1R3	Stard7	StAR-related lipid transfer protein 7, mitochondrial	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MLPRRLLAAW	LAGTRGGGLL	ALLANQCRFV	TGLRVRRAQQ	IAQLYGRLYS	ESSRRVLLGR
70	80	90	100	110	120
LWRRLHGRPG	HASALMAALA	GVFVWDEERI	QEEELQRSIN	EMKRLEEMSN	MFQSSGVQHH
130	140	150	160	170	180
PPEPKAQTEG	NEDSEGKEQR	WEMVMDKKHF	KLWRRPITGT	HLYQYRVFGT	YTDVTPRQFF
190	200	210	220	230	240
NVQLDTEYRK	KWDALVIKLE	VIERDVVSGS	EVLHWVTHFP	YPMYSRDYVY	VRRYSVDQEN
250	260	270	280	290	300
NMMVLVSRAV	EHPSVPESPE	FVRVRSYESQ	MVIRPHKSFD	ENGFDYLLTY	SDNPQTVFPR
310	320	330	340	350	360
YCVSWMVSSG	MPDFLEKLHM	ATLKAKNMEI	KVKDYISAKP	LEMSSEAKAT	SQSSERKNEG

SCGPARIEYA