AiPD: Autoinhibited Protein Database

Gene name	Slc1a7
Protein name	Excitatory amino acid transporter 5
Names	Solute carrier family 1 member 7
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:242607
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

460-539 (Predicted disordered autoinhibitory region) PR

460-539 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8JZR4-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs28127972	12	T>A	No	EVA
rs3388695278	68	L>Q	No	EVA
rs3388705624	74	M>V	No	EVA
rs3388698592	99	T>N	No	EVA
rs3388698224	130	K>M	No	EVA
rs3388700730	154	A>S	No	EVA
rs3388705613	200	D>E	No	EVA
rs28162576	243	T>M	No	EVA
rs3388698259	291	K>R	No	EVA
rs3388705593	338	L>F	No	EVA
rs3388700488	365	A>T	No	EVA
rs3388692063	366	R>H	No	EVA
rs3388705548	390	F>S	No	EVA
rs3388687220	436	V>M	No	EVA
rs3412746142	441	D>N	No	EVA
rs3388678155	498	T>S	No	EVA
rs3388701311	503	V>E	No	EVA
rs3388695664	522	L>V	No	EVA
rs247836424	524	P>S	No	EVA
rs3388699456	528	H>P	No	EVA

Type	Name	Position	InterPro Accession
conserved_site	Sodium:dicarboxylate symporter, conserved site	53 - 67	IPR018107-1
conserved_site	Sodium:dicarboxylate symporter, conserved site	370 - 393	IPR018107-2

		Description
EC Number
Subcellular Localization	Photoreceptor inner segment membrane ; Multi-pass membrane protein Synaptic cell membrane ; Multi-pass membrane protein	Located in both cone and rod photoreceptor terminals and in axon terminals of rod bipolar cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
axon terminus	Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
integral component of postsynaptic membrane	The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of presynaptic membrane	The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
photoreceptor cell terminal bouton	A specialized region of the axon terminus portion of a photoreceptor cell axon. A photoreceptor cell is a neuron specialized to detect and transduce light.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
anion transmembrane transporter activity	Enables the transfer of a negatively charged ion from one side of a membrane to the other.
extracellularly glutamate-gated chloride channel activity	Enables the transmembrane transfer of a chloride ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
glutamate:sodium symporter activity	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in).
L-glutamate transmembrane transporter activity	Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid.
neutral amino acid transmembrane transporter activity	Enables the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3.

Name	Definition
anion transmembrane transport	The process in which an anion is transported across a membrane.
chloride transmembrane transport	The process in which chloride is transported across a membrane.
L-glutamate transmembrane transport	The directed movement of L-glutamate across a membrane.
neurotransmitter reuptake	The directed movement of neurotransmitter molecules from the extrasynaptic space into the presynaptic cytosol.
neurotransmitter uptake	The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P46411	SLC1A3	Excitatory amino acid transporter 1	Bos taurus (Bovine)	PR
P43003	SLC1A3	Excitatory amino acid transporter 1	Homo sapiens (Human)	PR
O00341	SLC1A7	Excitatory amino acid transporter 5	Homo sapiens (Human)	PR
O35544	Slc1a6	Excitatory amino acid transporter 4	Mus musculus (Mouse)	PR
P56564	Slc1a3	Excitatory amino acid transporter 1	Mus musculus (Mouse)	PR
P24942	Slc1a3	Excitatory amino acid transporter 1	Rattus norvegicus (Rat)	PR