P56564

PR
Gene name
Slc1a3 (Eaat1, Gmt1)
Protein name
Excitatory amino acid transporter 1
Names
Glial high affinity glutamate transporter, High-affinity neuronal glutamate transporter, GluT-1, Sodium-dependent glutamate/aspartate transporter 1, GLAST-1, Solute carrier family 1 member 3
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:20512
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-69 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P56564

Entry ID Method Resolution Chain Position Source
AF-P56564-F1 Predicted AlphaFoldDB

38 variants for P56564

Variant ID(s) Position Change Description Diseaes Association Provenance
rs239354846 18 L>F No EVA
rs3405307414 20 Q>P No EVA
rs256720684 35 S>N No EVA
rs3389355038 74 S>I No EVA
rs3389368332 74 S>R No EVA
rs3389274397 75 Y>* No EVA
rs3389342325 75 Y>F No EVA
rs3389333113 76 R>G No EVA
rs3389333090 102 S>P No EVA
rs3389348081 114 K>* No EVA
rs3389355064 114 K>E No EVA
rs3389355186 130 T>N No EVA
rs3389333161 137 I>M No EVA
rs3389355230 146 H>Y No EVA
rs3389350399 160 K>N No EVA
rs3389323563 162 V>M No EVA
rs3411653384 173 L>S No EVA
rs3389304522 189 Q>K No EVA
rs3405726771 217 V>G No EVA
rs3389342313 218 S>* No EVA
rs3389347753 220 A>G No EVA
rs3405307434 220 A>S No EVA
rs3405817753 222 E>A No EVA
rs3405855767 228 R>L No EVA
rs3389315996 257 I>N No EVA
rs3389323583 262 E>* No EVA
rs3389314722 278 I>T No EVA
rs3389350374 301 I>T No EVA
rs3389350431 325 L>R No EVA
rs3389355012 351 G>W No EVA
rs3389347786 358 T>I No EVA
rs3389333110 372 T>I No EVA
rs3389354982 384 K>R No EVA
rs3389368380 391 L>F No EVA
rs3389347779 401 G>V No EVA
rs3389314705 409 A>V No EVA
rs3389333101 414 A>T No EVA
rs3389362520 439 G>V No EVA

No associated diseases with P56564

2 regional properties for P56564

Type Name Position InterPro Accession
conserved_site Sodium:dicarboxylate symporter, conserved site 84 - 98 IPR018107-1
conserved_site Sodium:dicarboxylate symporter, conserved site 392 - 415 IPR018107-2

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

13 GO annotations of cellular component

Name Definition
basal plasma membrane The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cell periphery The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
cell projection A prolongation or process extending from a cell, e.g. a flagellum or axon.
cell surface The external part of the cell wall and/or plasma membrane.
dendritic spine A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane protein complex Any protein complex that is part of a membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

8 GO annotations of molecular function

Name Definition
acidic amino acid transmembrane transporter activity Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have side chains with a negative charge at pH 7.3.
amino acid binding Binding to an amino acid, organic acids containing one or more amino substituents.
glutamate binding Binding to glutamate, the anion of 2-aminopentanedioic acid.
glutamate:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in).
high-affinity L-glutamate transmembrane transporter activity Enables the transfer of glutamate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
L-glutamate transmembrane transporter activity Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid.
metal ion binding Binding to a metal ion.
neutral amino acid transmembrane transporter activity Enables the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3.

23 GO annotations of biological process

Name Definition
auditory behavior The behavior of an organism in response to a sound.
cell morphogenesis involved in neuron differentiation The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron.
cellular response to cocaine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.
cellular sodium ion homeostasis Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.
chloride transmembrane transport The process in which chloride is transported across a membrane.
cranial nerve development The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.
D-aspartate import across plasma membrane The directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol.
gamma-aminobutyric acid biosynthetic process The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.
L-aspartate import across plasma membrane The directed movement of L-aspartate from outside of a cell, across the plasma membrane and into the cytosol.
L-glutamate import The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle.
L-glutamate import across plasma membrane The directed movement of L-glutamate from outside of a cell, across the plasma membrane and into the cytosol.
L-glutamate transmembrane transport The directed movement of L-glutamate across a membrane.
malate-aspartate shuttle The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle.
neuromuscular process controlling balance Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors.
positive regulation of synaptic transmission Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
potassium ion transmembrane transport A process in which a potassium ion is transported from one side of a membrane to the other.
response to amino acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
response to antibiotic Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
response to inorganic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.
response to light stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
response to wounding Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
sensory perception of sound The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P46411 SLC1A3 Excitatory amino acid transporter 1 Bos taurus (Bovine) PR
P43003 SLC1A3 Excitatory amino acid transporter 1 Homo sapiens (Human) PR
O35544 Slc1a6 Excitatory amino acid transporter 4 Mus musculus (Mouse) PR
Q8JZR4 Slc1a7 Excitatory amino acid transporter 5 Mus musculus (Mouse) PR
P24942 Slc1a3 Excitatory amino acid transporter 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MTKSNGEEPR MGGRMERLQQ GVRKRTLLAK KKVQSLTKED VKSYLFRNAF VLLTVTAVIV
70 80 90 100 110 120
GTILGFALRP YKMSYREVKY FSFPGELLMR MLQMLVLPLI ISSLVTGMAA LDSKASGKMG
130 140 150 160 170 180
MRAVVYYMTT TIIAVVIGII IVIIIHPGKG TKENMYREGK IVQVTAADAF LDLIRNMFPP
190 200 210 220 230 240
NLVEACFKQF KTSYEKRSFK VPIQSNETLL GAVINNVSEA METLTRIREE MVPVPGSVNG
250 260 270 280 290 300
VNALGLVVFS MCFGFVIGNM KEQGQALREF FDSLNEAIMR LVAVIMWYAP LGILFLIAGK
310 320 330 340 350 360
IVEMEDMGVI GGQLAMYTVT VIVGLLIHAV IVLPLLYFLV TRKNPWVFIG GLLQALITAL
370 380 390 400 410 420
GTSSSSATLP ITFKCLEENN GVDKRITRFV LPVGATINMD GTALYEALAA IFIAQVNNFD
430 440 450 460 470 480
LNFGQIITIS ITATAASIGA AGIPQAGLVT MVIVLTSVGL PTDDITLIIA VDWFLDRLRT
490 500 510 520 530 540
TTNVLGDSLG AGIVEHLSRH ELKNRDVEMG NSVIEENEMK KPYQLIAQDN EPEKPVADSE
TKM