Q8BYR8
Gene name |
Slc41a2 |
Protein name |
Solute carrier family 41 member 2 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:338365 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BYR8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BYR8-F1 | Predicted | AlphaFoldDB |
31 variants for Q8BYR8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3401491887 | 15 | A>D | No | EVA | |
| rs3389120725 | 48 | V>F | No | EVA | |
| rs3389115255 | 63 | G>A | No | EVA | |
| rs3389117561 | 69 | L>E | No | EVA | |
| rs3389117531 | 114 | A>D | No | EVA | |
| rs226293500 | 136 | L>M | No | EVA | |
| rs3389111424 | 145 | V>L | No | EVA | |
| rs3389129731 | 170 | A>* | No | EVA | |
| rs3389111407 | 242 | A>V | No | EVA | |
| rs3401449224 | 274 | H>R | No | EVA | |
| rs226553879 | 276 | I>M | No | EVA | |
| rs3401391272 | 276 | I>T | No | EVA | |
| rs245719418 | 276 | I>V | No | EVA | |
| rs3401378399 | 279 | C>* | No | EVA | |
| rs3401480059 | 286 | A>T | No | EVA | |
| rs3400779585 | 292 | L>Q | No | EVA | |
| rs3389120731 | 295 | I>K | No | EVA | |
| rs3389095352 | 356 | F>S | No | EVA | |
| rs3389115259 | 385 | I>V | No | EVA | |
| rs3389124653 | 387 | A>S | No | EVA | |
| rs3389115228 | 388 | M>L | No | EVA | |
| rs3389129704 | 425 | V>E | No | EVA | |
| rs3389121957 | 491 | K>N | No | EVA | |
| rs3389060398 | 515 | T>A | No | EVA | |
| rs3401388194 | 516 | L>A | No | EVA | |
| rs3389118028 | 516 | L>Q | No | EVA | |
| rs3389107616 | 522 | W>L | No | EVA | |
| rs3413032985 | 524 | V>I | No | EVA | |
| rs3401539590 | 538 | S>* | No | EVA | |
| rs3389129757 | 557 | S>R | No | EVA | |
| rs3389115204 | 562 | W>* | No | EVA |
No associated diseases with Q8BYR8
2 regional properties for Q8BYR8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SLC41A/MgtE, integral membrane domain | 200 - 333 | IPR006667-1 |
| domain | SLC41A/MgtE, integral membrane domain | 414 - 556 | IPR006667-2 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| inorganic cation transmembrane transporter activity | Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| metal ion transport | The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5ZHX6 | SLC41A2 | Solute carrier family 41 member 2 | Gallus gallus (Chicken) | PR |
| Q8IVJ1 | SLC41A1 | Solute carrier family 41 member 1 | Homo sapiens (Human) | PR |
| Q96JW4 | SLC41A2 | Solute carrier family 41 member 2 | Homo sapiens (Human) | PR |
| Q8BJA2 | Slc41a1 | Solute carrier family 41 member 1 | Mus musculus (Mouse) | PR |
| Q921R8 | Slc41a3 | Solute carrier family 41 member 3 | Mus musculus (Mouse) | PR |
| Q3SWT5 | Slc41a3 | Solute carrier family 41 member 3 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTHSKGRPVT | YKTSASPESG | GGFVDWTLNL | NTIQSDKFLN | LLLSMVPVIY | QKNQEDRHKK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VNGIWQDGLS | GAAQTFSKRS | EPHLDYHEFS | EQAFHSSSSG | HTPASCSPKY | DDYAGYNYCD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GREASETTAM | LQDEDLSSEG | DDVIVETSQR | IPKESSGVMA | LQILVPFLLA | GFGTVSAGMV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LDIVQHWEVF | KNVTEVFILV | PALLGLKGNL | EMTLASRLST | AVNVGKMDSP | IEKWNLIIGN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LALKQVQATV | VGFLAAVAAI | ILGWIPEGKY | YLSHSILLCS | SSVATAFIAS | LLQGIIMVGV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IVGSKKTGIN | PDNVATPIAA | SFGDLITLAI | LAWISQGLYS | CLETYYYISP | LVCAFFLALT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PIWIIIAAKH | PATRTVLHSG | WEPVITAMVI | SSIGGLILDT | TVSDPNLVGI | VVYTPVINGI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GGNLVAIQAS | RISTYLHLHS | IPGELPEEPK | GCSYPFRTFF | GSGVNNKSAQ | VLLLFVIPGH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LIFLYTIHLM | KSGHTSLTVV | FVVVYLFAAV | LQVFTLLWIA | DWMVHRFWRK | GKDPDSFSIP |
| 550 | 560 | 570 | |||
| YLTALGDLLG | TALLALSFHF | LWLIGDRDGD | VGD |