AiPD: Autoinhibited Protein Database

Gene name	Slc41a1
Protein name	Solute carrier family 41 member 1
Names
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:98396
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-116 (Predicted disordered autoinhibitory region) PR

1-116 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8BJA2-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388498554	6	E>G	No	EVA
rs3388497048	43	D>E	No	EVA
rs3388495925	50	I>F	No	EVA
rs3388498629	62	E>D	No	EVA
rs3388498523	87	P>A	No	EVA
rs3388498550	187	T>K	No	EVA
rs3388497945	197	A>T	No	EVA
rs3388498594	207	H>Y	No	EVA
rs3388498539	232	G>R	No	EVA
rs3388498555	268	L>F	No	EVA
rs48699171	271	G>S	No	EVA
rs864284201	283	W>R	No	EVA
rs3388499480	302	V>A	No	EVA
rs3390591167	319	W>C	No	EVA
rs3390609089	319	W>S	No	EVA
rs3390640262	320	E>Q	No	EVA
rs3388497941	324	I>F	No	EVA
rs3388499583	339	T>A	No	EVA
rs3390562907	378	G>D	No	EVA
rs3388496964	395	C>Y	No	EVA
rs3388497074	431	G>D	No	EVA
rs3388499485	439	I>T	No	EVA
rs3388498536	460	D>N	No	EVA
rs3388499591	474	D>H	No	EVA
rs3388494778	503	I>F	No	EVA

Type	Name	Position	InterPro Accession
domain	SLC41A/MgtE, integral membrane domain	138 - 271	IPR006667-1
domain	SLC41A/MgtE, integral membrane domain	352 - 495	IPR006667-2

		Description
EC Number
Subcellular Localization	Cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
basolateral plasma membrane	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

Name	Definition
inorganic cation transmembrane transporter activity	Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.
magnesium ion transmembrane transporter activity	Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other.
magnesium:sodium antiporter activity	Catalysis of the reaction: Na+(in) + Mg2+(out) = Na+(out) + Mg2+(in).
transmembrane transporter activity	Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

Name	Definition
cellular magnesium ion homeostasis	Any process involved in the maintenance of an internal steady state of magnesium ions at the level of a cell.
cellular response to magnesium ion	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus.
magnesium ion transmembrane transport	The directed movement of magnesium ion across a membrane.
magnesium ion transport	The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
metal ion transport	The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5ZHX6	SLC41A2	Solute carrier family 41 member 2	Gallus gallus (Chicken)	PR
Q8IVJ1	SLC41A1	Solute carrier family 41 member 1	Homo sapiens (Human)	PR
Q96JW4	SLC41A2	Solute carrier family 41 member 2	Homo sapiens (Human)	PR
Q8BYR8	Slc41a2	Solute carrier family 41 member 2	Mus musculus (Mouse)	PR
Q921R8	Slc41a3	Solute carrier family 41 member 3	Mus musculus (Mouse)	PR
Q3SWT5	Slc41a3	Solute carrier family 41 member 3	Rattus norvegicus (Rat)	PR