Q8BMJ3

PR
Gene name
Eif1ax (Eif1ay)
Protein name
Eukaryotic translation initiation factor 1A, X-chromosomal
Names
eIF-1A X isoform, Eukaryotic translation initiation factor 4C, eIF-4C
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:66235
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BMJ3

Entry ID Method Resolution Chain Position Source
AF-Q8BMJ3-F1 Predicted AlphaFoldDB

6 variants for Q8BMJ3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3412477647 37 Q>E No EVA
rs3389590525 58 L>V No EVA
rs3389539122 61 I>F No EVA
rs3411071338 64 K>N No EVA
rs3389592905 71 I>V No EVA
rs3389532569 75 D>E No EVA

No associated diseases with Q8BMJ3

2 regional properties for Q8BMJ3

Type Name Position InterPro Accession
domain RNA-binding domain, S1, IF1 type 22 - 96 IPR006196
conserved_site Translation initiation factor 1A (eIF-1A), conserved site 41 - 63 IPR018104

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

1 GO annotations of biological process

Name Definition
translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6GVM3 EIF1AY Eukaryotic translation initiation factor 1A, Y-chromosomal Pan troglodytes (Chimpanzee) PR
P47813 EIF1AX Eukaryotic translation initiation factor 1A, X-chromosomal Homo sapiens (Human) PR
O14602 EIF1AY Eukaryotic translation initiation factor 1A, Y-chromosomal Homo sapiens (Human) PR
10 20 30 40 50 60
MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAM CFDGVKRLCH
70 80 90 100 110 120
IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA RSLKAYGELP EHAKINETDT
130 140
FGPGDDDEIQ FDDIGDDDED IDDI