O14602

PR
Gene name
EIF1AY
Protein name
Eukaryotic translation initiation factor 1A, Y-chromosomal
Names
eIF-1A Y isoform, Eukaryotic translation initiation factor 4C, eIF-4C
Species
Homo sapiens (Human)
KEGG Pathway
hsa:9086
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O14602

Entry ID Method Resolution Chain Position Source
AF-O14602-F1 Predicted AlphaFoldDB

17 variants for O14602

Variant ID(s) Position Change Description Diseaes Association Provenance
CA337491695
rs867592910
 11 N>K No ClinGen
Ensembl
CA414854562
rs1258138681
 13 R>H No ClinGen
gnomAD
CA10575115
rs747858565
 18 E>Q No ClinGen
ExAC
gnomAD
rs370005570
CA10575123
 46 R>Q No ClinGen
ESP
ExAC
gnomAD
rs372616106
CA10575124
 54 G>C No ClinGen
ESP
ExAC
gnomAD
CA414854375
rs1603578946
 63 G>E No ClinGen
Ensembl
CA414854400
rs1603578947
 65 L>* No ClinGen
Ensembl
CA414854395
rs769611401
 65 L>M No ClinGen
ExAC
gnomAD
CA414854416
rs1603578949
 66 R>K No ClinGen
Ensembl
CA10575129
rs750548572
 71 I>V No ClinGen
ExAC
gnomAD
rs1194229636
CA414854726
 80 G>A No ClinGen
gnomAD
CA414854764
rs1603578958
 83 D>Y No ClinGen
Ensembl
CA337491874
rs955533121
 86 D>Y No ClinGen
Ensembl
CA10575138
rs777390802
 105 A>T No ClinGen
ExAC
gnomAD
TCGA novel 115 I>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs922376609
CA337491898
 116 N>S No ClinGen
Ensembl
CA10575145
rs762602059
 123 P>A No ClinGen
ExAC
gnomAD

No associated diseases with O14602

2 regional properties for O14602

Type Name Position InterPro Accession
domain RNA-binding domain, S1, IF1 type 22 - 96 IPR006196
conserved_site Translation initiation factor 1A (eIF-1A), conserved site 41 - 63 IPR018104

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

1 GO annotations of biological process

Name Definition
translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6GVM3 EIF1AY Eukaryotic translation initiation factor 1A, Y-chromosomal Pan troglodytes (Chimpanzee) PR
P47813 EIF1AX Eukaryotic translation initiation factor 1A, X-chromosomal Homo sapiens (Human) PR
Q8BMJ3 Eif1ax Eukaryotic translation initiation factor 1A, X-chromosomal Mus musculus (Mouse) PR
10 20 30 40 50 60
MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAL CFDGVKRLCH
70 80 90 100 110 120
IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA RSLKAYGELP EHAKINETDT
130 140
FGPGDDDEIQ FDDIGDDDED IDDI