P47813

PR
Gene name
EIF1AX (EIF1A, EIF4C)
Protein name
Eukaryotic translation initiation factor 1A, X-chromosomal
Names
eIF-1A X isoform, Eukaryotic translation initiation factor 4C, eIF-4C
Species
Homo sapiens (Human)
KEGG Pathway
hsa:1964
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

20 structures for P47813

Entry ID Method Resolution Chain Position Source
1D7Q NMR - A 2-144 PDB
3ZJY X-ray 360 A C 1-112 PDB
4KZY X-ray 701 A n 1-144 PDB
4KZZ X-ray 703 A n 1-144 PDB
6YBW EM 310 A q 1-144 PDB
6ZMW EM 370 A q 1-144 PDB
6ZP4 EM 290 A G 1-144 PDB
7A09 EM 350 A G 1-112 PDB
7QP6 EM 470 A q 1-144 PDB
7QP7 EM 370 A q 1-144 PDB
7SYQ EM 380 A A 1-144 PDB
7SYR EM 360 A A 1-144 PDB
7SYS EM 350 A A 1-144 PDB
7SYV EM 390 A A 1-144 PDB
7SYW EM 370 A A 1-144 PDB
7SYX EM 370 A A 1-144 PDB
7TQL EM 340 A 4 24-113 PDB
8OZ0 EM 350 A G 1-144 PDB
8PPL EM 265 A Iq 1-144 PDB
AF-P47813-F1 Predicted AlphaFoldDB

23 variants for P47813

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1603415028
RCV000984125
CA412507801
COSM3844308
 99 E>K Multiple myeloma breast [ClinVar, Cosmic] Yes ClinGen
cosmic curated
ClinVar
Ensembl
dbSNP
rs868028391
CA327472184
 7 K>E No ClinGen
Ensembl
TCGA novel 7 K>R Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs757280897
CA10366007
 10 K>E Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
CA327472183
rs967472465
 14 R>G No ClinGen
TOPMed
CA10365974
rs763748273
 46 R>W No ClinGen
ExAC
gnomAD
rs767982673
CA10365971
 55 V>I No ClinGen
ExAC
gnomAD
TCGA novel 61 I>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA412508955
rs1235062718
 63 G>E No ClinGen
gnomAD
CA412508925
rs1436668471
 65 L>* No ClinGen
gnomAD
CA412508928
rs1203045832
 65 L>M No ClinGen
gnomAD
rs1224966367
CA412508895
 66 R>K No ClinGen
gnomAD
TCGA novel 70 W>R Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1294141439
CA412508040
 76 I>V No ClinGen
TOPMed
TCGA novel 84 Y>C Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA412507781
rs1382959705
 101 R>S No ClinGen
gnomAD
CA412507777
rs1364416038
 102 S>I No ClinGen
gnomAD
rs1287361370
CA412507772
 103 L>M No ClinGen
gnomAD
CA327471647
rs71541905
 104 K>Q No ClinGen
Ensembl
rs1390585322
CA412507403
 141 I>T No ClinGen
gnomAD
rs1169029411
CA412507388
 142 D>E No ClinGen
gnomAD
CA327471530
rs886641674
 142 D>N No ClinGen
Ensembl
rs768926880 143 D>= Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA

No associated diseases with P47813

3 regional properties for P47813

Type Name Position InterPro Accession
domain Glycoside hydrolase, family 5 69 - 268 IPR001547
conserved_site Glycoside hydrolase, family 5, conserved site 258 - 267 IPR018087
domain Glycoside hydrolase family 5, C-terminal domain 654 - 736 IPR041036

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
translation factor activity, RNA binding Functions during translation by binding to RNA during polypeptide synthesis at the ribosome.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

1 GO annotations of biological process

Name Definition
translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6GVM3 EIF1AY Eukaryotic translation initiation factor 1A, Y-chromosomal Pan troglodytes (Chimpanzee) PR
O14602 EIF1AY Eukaryotic translation initiation factor 1A, Y-chromosomal Homo sapiens (Human) PR
Q8BMJ3 Eif1ax Eukaryotic translation initiation factor 1A, X-chromosomal Mus musculus (Mouse) PR
10 20 30 40 50 60
MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAM CFDGVKRLCH
70 80 90 100 110 120
IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA RSLKAYGELP EHAKINETDT
130 140
FGPGDDDEIQ FDDIGDDDED IDDI