Q8BH69
Gene name |
Sephs1 (Sps1) |
Protein name |
Selenide, water dikinase 1 |
Names |
Selenium donor protein 1, Selenophosphate synthase 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:109079 |
EC number |
2.7.9.3: Phosphotransferases with paired acceptors |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BH69
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BH69-F1 | Predicted | AlphaFoldDB |
13 variants for Q8BH69
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388529187 | 4 | R>L | No | EVA | |
| rs3388523749 | 63 | R>* | No | EVA | |
| rs3388526141 | 63 | R>L | No | EVA | |
| rs3388526181 | 66 | I>F | No | EVA | |
| rs3388524100 | 78 | G>D | No | EVA | |
| rs3388523775 | 160 | T>I | No | EVA | |
| rs3388526192 | 167 | N>D | No | EVA | |
| rs3388529211 | 179 | V>L | No | EVA | |
| rs3391211175 | 214 | W>G | No | EVA | |
| rs3388523639 | 237 | Y>* | No | EVA | |
| rs3388523662 | 303 | S>N | No | EVA | |
| rs3388527173 | 364 | A>S | No | EVA | |
| rs3388524157 | 385 | N>S | No | EVA |
No associated diseases with Q8BH69
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.9.3 | Phosphotransferases with paired acceptors |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| identical protein binding | Binding to an identical protein or proteins. |
| metal ion binding | Binding to a metal ion. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| selenide, water dikinase activity | Catalysis of the reaction: ATP + H(2)O + hydrogen selenide = AMP + 3 H(+) + phosphate + selenophosphorate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| selenocysteine biosynthetic process | The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0VC82 | SEPHS1 | Selenide, water dikinase 1 | Bos taurus (Bovine) | PR |
| P49903 | SEPHS1 | Selenide, water dikinase 1 | Homo sapiens (Human) | PR |
| Q6GL12 | sephs1 | Selenide, water dikinase 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q7ZW38 | sephs1 | Selenide, water dikinase 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSTRESFNPE | TYELDKSFRL | TRFTELKGTG | CKVPQDVLQK | LLESLQENHF | QEDEQFLGAV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MPRLGIGMDT | CVIPLRHGGL | SLVQTTDYIY | PIVDDPYMMG | RIACANVLSD | LYAMGVTECD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NMLMLLGVSN | KMTDRERDKV | IPLIIQGFKD | AAEEAGTSVT | GGQTVLNPWI | VLGGVATTVC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QPNEFIMPDN | AVPGDVLVLT | KPLGTQVAVA | VHQWLDIPEK | WNKIKLVVTQ | EDVELAYQEA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MMNMARLNRT | AAGLMHTFNA | HAATDITGFG | ILGHAQNLAK | QQRNEVSFVI | HNLPVLAKMA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AVSKACGNMF | GLMHGTCPET | SGGLLICLPR | EQAARFCAEI | KSPKYGEGHQ | AWIIGIVEKG |
| 370 | 380 | 390 | |||
| NRTARIIDKP | RIIEVAPQVA | TQNVNPTPGA | TS |