AiPD: Autoinhibited Protein Database

Gene name	SEPHS1
Protein name	Selenide, water dikinase 1
Names	Selenium donor protein 1, Selenophosphate synthase 1
Species	Bos taurus (Bovine)
KEGG Pathway	bta:507470
EC number	2.7.9.3: Phosphotransferases with paired acceptors
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-79 (Predicted disordered autoinhibitory region) PR

1-79 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q0VC82-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs456064355	2	S>A	No	EVA
rs435996558	6	S>P	No	EVA
rs467153658	10	E>A	No	EVA
rs454015392	11	S>R	No	EVA
rs433844397	11	S>R	No	EVA
rs445027870	48	N>T	No	EVA
rs482808479	50	F>L	No	EVA
rs469524465	51	Q>K	No	EVA
rs449356036	53	D>N	No	EVA
rs460464715	57	L>R	No	EVA
rs480620674	57	L>V	No	EVA
rs440709165	61	M>V	No	EVA
rs467684023	101	R>G	No	EVA
rs453953177	106	N>D	No	EVA
rs433780996	110	D>V	No	EVA
rs465127941	133	T>A	No	EVA
rs434023654	134	D>Y	No	EVA
rs453333922	184	E>Q	No	EVA
rs433149803	186	I>L	No	EVA
rs476822182	187	M>I	No	EVA
rs456710853	188	P>S	No	EVA
rs478425639	207	V>E	No	EVA
rs454562980	216	D>G	No	EVA
rs451841666	244	M>I	No	EVA
rs438115378	248	N>K	No	EVA
rs441751764	302	V>E	No	EVA
rs473345561	303	S>I	No	EVA
rs459679733	305	A>D	No	EVA
rs439571555	316	T>I	No	EVA
rs445838152	368	D>E	No	EVA

Type	Name	Position	InterPro Accession
domain	PurM-like, C-terminal domain	193 - 367	IPR010918
domain	PurM-like, N-terminal domain	82 - 169	IPR016188

		Description
EC Number	2.7.9.3	Phosphotransferases with paired acceptors
Subcellular Localization	Cell membrane ; Peripheral membrane protein Nucleus membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding	Binding to a metal ion.
protein heterodimerization activity	Binding to a nonidentical protein to form a heterodimer.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
selenide, water dikinase activity	Catalysis of the reaction: ATP + H(2)O + hydrogen selenide = AMP + 3 H(+) + phosphate + selenophosphorate.

Name	Definition
phosphorylation	The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
selenocysteine biosynthetic process	The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P49903	SEPHS1	Selenide, water dikinase 1	Homo sapiens (Human)	PR
Q8BH69	Sephs1	Selenide, water dikinase 1	Mus musculus (Mouse)	PR
Q6GL12	sephs1	Selenide, water dikinase 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q7ZW38	sephs1	Selenide, water dikinase 1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR