Q6GL12

PR
Gene name
sephs1
Protein name
Selenide, water dikinase 1
Names
Selenium donor protein 1, Selenophosphate synthase 1
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:448749
EC number
2.7.9.3: Phosphotransferases with paired acceptors
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-40 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6GL12

Entry ID Method Resolution Chain Position Source
AF-Q6GL12-F1 Predicted AlphaFoldDB

No variants for Q6GL12

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6GL12

No associated diseases with Q6GL12

2 regional properties for Q6GL12

Type Name Position InterPro Accession
domain PurM-like, C-terminal domain 193 - 367 IPR010918
domain PurM-like, N-terminal domain 82 - 169 IPR016188

Functions

Description
EC Number 2.7.9.3 Phosphotransferases with paired acceptors
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
  • Nucleus membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.
protein homodimerization activity Binding to an identical protein to form a homodimer.
selenide, water dikinase activity Catalysis of the reaction: ATP + H(2)O + hydrogen selenide = AMP + 3 H(+) + phosphate + selenophosphorate.

2 GO annotations of biological process

Name Definition
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
selenocysteine biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q0VC82 SEPHS1 Selenide, water dikinase 1 Bos taurus (Bovine) PR
P49903 SEPHS1 Selenide, water dikinase 1 Homo sapiens (Human) PR
Q8BH69 Sephs1 Selenide, water dikinase 1 Mus musculus (Mouse) PR
Q7ZW38 sephs1 Selenide, water dikinase 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MSVRESFNPE SYELDKSFRL TRFAELKGTG CKVPQDVLQK LLESLQENHF QEDEQFLGAV
70 80 90 100 110 120
MPRLGIGMDT CVIPLRHGGL SLVQTTDYIY PIVDDPYMMG RIACANVLSD LYAMGVTECD
130 140 150 160 170 180
NMLMLLGVSN KLTDRERDKV MPLIIQGFKD AAEEAGTSVT GGQTVLNPWV VLGGVATTVC
190 200 210 220 230 240
QPNEFIMPDN AVPGDVLVLT KPLGTQVAVA VHQWLDIPEK WNKIKLVVTQ EDVELAYQEA
250 260 270 280 290 300
MMNMARLNRT AAGLMHTFNA HAATDITGFG ILGHAQNLAK QQRNEVSFVI HNLPVLAKMA
310 320 330 340 350 360
AVSKACGNMF GLMHGSCPET SGGLLICLPR EQAARFCAEI KSPKYGEGHQ AWIIGIVEKG
370 380 390
NRTARIIDKP RIIEVAPQVA SQNVNPTPGA TS