AiPD: Autoinhibited Protein Database

P49903

Gene name	SEPHS1 (SELD, SPS, SPS1)
Protein name	Selenide, water dikinase 1
Names	Selenium donor protein 1, Selenophosphate synthase 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:22929
EC number	2.7.9.3: Phosphotransferases with paired acceptors
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-44 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-44 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for P49903

Entry ID	Method	Resolution	Chain	Position	Source
3FD5	X-ray	190 A	A/B	1-392	PDB
3FD6	X-ray	195 A	A/B	1-392	PDB
AF-P49903-F1	Predicted				AlphaFoldDB

182 variants for P49903

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1274393616 CA376047712	6	S>F		No	ClinGen gnomAD
CA376047715 rs1468504932	6	S>T		No	ClinGen gnomAD
rs781715713 CA5412924	9	P>L		No	ClinGen ExAC gnomAD
CA203322498 COSM109749 rs146099433 COSM109748	9	P>S	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
CA5412922 rs747451158	11	S>N		No	ClinGen ExAC gnomAD
rs762547449 CA5412921	12	Y>H		No	ClinGen ExAC gnomAD
rs762547449 CA376047674	12	Y>N		No	ClinGen ExAC gnomAD
TCGA novel	13	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1440317431 CA376047648	15	D>G		No	ClinGen gnomAD
rs1451535181 CA376047618	19	R>Q		No	ClinGen gnomAD
rs1327907950 CA376047619	19	R>W		No	ClinGen gnomAD
TCGA novel	23	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA376047594 rs1306213210	23	F>Y		No	ClinGen TOPMed
CA376047551 rs1410721212	29	T>R		No	ClinGen TOPMed
CA376047541 rs1282867284	31	C>G		No	ClinGen TOPMed
CA376047519 rs1192581527	34	P>S		No	ClinGen gnomAD
TCGA novel	35	Q>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767617835 CA5412914	41	L>F		No	ClinGen ExAC gnomAD
rs751406811 CA5412912	43	E>A		No	ClinGen ExAC gnomAD
TCGA novel	43	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA376047460 rs1216999560	43	E>Q		No	ClinGen gnomAD
rs764177751 CA5412911	44	S>Y		No	ClinGen ExAC gnomAD
CA203322399 rs898195245	49	H>D		No	ClinGen gnomAD
CA376047404 rs1380538190	50	F>L		No	ClinGen gnomAD
rs775485871 CA5412909	52	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1361207408 CA376047395	52	E>K		No	ClinGen gnomAD
rs1432683072 CA376047383	53	D>V		No	ClinGen gnomAD
rs1483092059 CA376047380	54	E>Q		No	ClinGen TOPMed
CA376047354 rs1588551206	57	L>R		No	ClinGen Ensembl
CA376047351 rs1588551199	58	G>R		No	ClinGen Ensembl
CA376047337 rs1167735253	60	V>F		No	ClinGen gnomAD
rs892254890 CA203322384	61	M>T		No	ClinGen TOPMed
rs1427371422 CA376047323	62	P>S		No	ClinGen gnomAD
rs1372459207 CA376047319	63	R>G		No	ClinGen TOPMed
CA5412905 rs771511207	64	L>F		No	ClinGen ExAC
CA5412871 rs765405455	66	I>M		No	ClinGen ExAC gnomAD
rs535526745 CA5412870	68	M>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	69	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1564451575 CA376046866	72	V>I		No	ClinGen Ensembl
rs1455051268 CA376046849	74	P>R		No	ClinGen Ensembl
rs753857844 CA5412869	77	H>Y		No	ClinGen ExAC gnomAD
CA5412867 rs760732126	78	G>S		No	ClinGen ExAC gnomAD
CA376046796 rs1272526394	83	V>I		No	ClinGen gnomAD
CA376046776 rs1241082437	86	T>A		No	ClinGen TOPMed
rs767956492 CA5412865	89	I>V		No	ClinGen ExAC gnomAD
CA376046735 rs1564451521	91	P>L		No	ClinGen Ensembl
CA376046728 rs774883874	92	I>M		No	ClinGen ExAC TOPMed gnomAD
COSM916304 CA5412862 rs769518585 COSM916305	93	V>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA5412860 rs776217380	95	D>N		No	ClinGen ExAC TOPMed gnomAD
CA376046696 rs1390899202	97	Y>F		No	ClinGen TOPMed
CA376046503 rs1402240125	101	R>S		No	ClinGen TOPMed
CA376046494 rs1474740428	103	A>T		No	ClinGen gnomAD
CA5412827 rs752102842	103	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5412825 rs542605530	105	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1271689318 CA376046472	106	N>S		No	ClinGen gnomAD
TCGA novel	108	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1280600680 CA376046439	111	L>V		No	ClinGen gnomAD
rs1314602706 CA376046430	112	Y>C		No	ClinGen TOPMed
CA203314576 rs372858494	114	M>V		No	ClinGen ESP gnomAD
CA5412820 rs200835015	117	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs773953901 CA203314543	126	L>P		No	ClinGen Ensembl
CA376046323 rs1308125850	128	V>I		No	ClinGen TOPMed
CA5412814 rs769996817	130	N>S		No	ClinGen ExAC TOPMed gnomAD
CA5412813 rs746078177	131	K>N		No	ClinGen ExAC gnomAD
TCGA novel	131	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1468296697 CA376046280 COSM1504592 COSM1504593	134	D>N	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs966970698 CA203312082	141	M>V		No	ClinGen Ensembl
CA5412791 rs747037286	142	P>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	144	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5412790 rs182887196	145	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs758874151 CA5412789	146	Q>R		No	ClinGen ExAC gnomAD
CA203312054 rs373442320	147	G>A		No	ClinGen ESP TOPMed
CA376045873 rs1379780114	150	D>H		No	ClinGen TOPMed
rs149225659 CA5412787	151	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	153	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755275432 CA5412786	155	A>G		No	ClinGen ExAC TOPMed gnomAD
CA5412783 rs756922006	158	S>F		No	ClinGen ExAC TOPMed gnomAD
CA5412782 rs150474037	159	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA5412779 rs775272148	162	G>S		No	ClinGen ExAC gnomAD
rs1172500826 CA376045767	167	N>T		No	ClinGen gnomAD
TCGA novel	169	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773637313 CA5412773	177	T>N		No	ClinGen ExAC gnomAD
CA5412769 rs755539311	180	C>G		No	ClinGen ExAC TOPMed gnomAD
CA376045661 rs1312818818	183	N>S		No	ClinGen TOPMed gnomAD
CA376045662 rs1233717375	183	N>Y		No	ClinGen gnomAD
rs1303388956 CA376045647	185	F>L		No	ClinGen gnomAD
rs886332812 CA203311936	187	M>T		No	ClinGen Ensembl
rs770128438 CA5412746	190	N>S		No	ClinGen ExAC TOPMed gnomAD
CA376045072 rs1258469101	196	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1480331383 CA376044973	202	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA376044893 rs1332506870	208	A>V		No	ClinGen gnomAD
rs778490277 CA5412741	211	V>G		No	ClinGen ExAC gnomAD
TCGA novel	214	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754602419 CA5412740	215	L>Q		No	ClinGen ExAC gnomAD
CA5412717 rs756142199	218	P>L		No	ClinGen ExAC gnomAD
rs925487659 CA203307515	222	N>S		No	ClinGen TOPMed
CA376044165 rs1208158290	224	I>V		No	ClinGen gnomAD
rs1234611315 CA376043970	235	L>V		No	ClinGen gnomAD
CA203307513 rs760357700	236	A>D		No	ClinGen Ensembl
CA376043959 rs1333276169	236	A>S		No	ClinGen gnomAD
rs914061314 CA203307510	237	Y>C		No	ClinGen TOPMed gnomAD
CA203307511 rs945563730	237	Y>N		No	ClinGen Ensembl
rs757062437 CA5412715	240	A>G		No	ClinGen ExAC gnomAD
rs757062437 CA5412714	240	A>V		No	ClinGen ExAC gnomAD
rs986930410 CA203307497	242	M>I		No	ClinGen Ensembl
rs764345721 CA5412712	242	M>L		No	ClinGen ExAC TOPMed gnomAD
rs1432999081 CA376043796	244	M>T		No	ClinGen gnomAD
COSM1225219 CA203307482 rs955621821 COSM1225218	245	A>V	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs1173170590 CA376043752	247	L>P		No	ClinGen gnomAD
rs1371222947 CA376043744	248	N>D		No	ClinGen gnomAD
TCGA novel	250	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	253	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745416609 CA5412676	254	L>F		No	ClinGen ExAC gnomAD
rs745416609 CA376043084	254	L>V		No	ClinGen ExAC gnomAD
CA5412675 rs781150779	255	M>T		No	ClinGen ExAC gnomAD
TCGA novel	256	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA376043029 rs1194827024	257	T>M		No	ClinGen TOPMed
rs777553816 CA5412672	259	N>S		No	ClinGen ExAC gnomAD
CA376042990 rs1162752688	260	A>S		No	ClinGen TOPMed
rs1588532667 CA376042978	261	H>P		No	ClinGen Ensembl
rs1164623526 CA376042949	263	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1468213474 CA376042910	265	D>G		No	ClinGen gnomAD
CA376042900 rs1237033461	266	I>V		No	ClinGen gnomAD
TCGA novel	267	T>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779155992 CA5412669	267	T>M		No	ClinGen ExAC gnomAD
CA5412667 rs753897686	272	L>S		No	ClinGen ExAC gnomAD
CA376042754 rs1300226752	275	A>T		No	ClinGen TOPMed
rs762321273 CA5412661	277	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1259633467 CA376042670	280	K>R		No	ClinGen TOPMed
rs769368773 CA5412659	281	Q>R		No	ClinGen ExAC gnomAD
CA376042616 rs759043625	284	N>K		No	ClinGen ExAC TOPMed gnomAD
rs767360719 CA203303857	284	N>S		No	ClinGen Ensembl
rs1474459084 CA376042625	284	N>Y		No	ClinGen gnomAD
rs373971793 CA5412657	285	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA5412656 rs151205320	287	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
TCGA novel	296	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5412650 rs148657465	296	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1361407515 CA376042351	309	M>I		No	ClinGen TOPMed
rs1217496940 CA376042356	309	M>L		No	ClinGen gnomAD
rs375854945 CA5412645	309	M>T		No	ClinGen ESP ExAC gnomAD
CA5412643 rs144150402	311	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	312	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5412642 rs764888887	313	M>T		No	ClinGen ExAC gnomAD
rs1368139587 CA376042330	313	M>V		No	ClinGen TOPMed gnomAD
rs1381714018 CA376042321	314	H>Y		No	ClinGen TOPMed
rs892589418 CA203303808	315	G>A		No	ClinGen Ensembl
CA5412640 rs776415520	316	T>S		No	ClinGen ExAC TOPMed gnomAD
rs1298410502 CA376042292	318	P>L	Variant assessed as Somatic; 4.645e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA5412638 rs760228317	320	T>I		No	ClinGen ExAC gnomAD
rs1174666851 CA376042275	321	S>*		No	ClinGen gnomAD
rs765975551	322	G>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA376041492 rs1272344983	323	G>S		No	ClinGen gnomAD
CA376041287 rs1293236433	335	R>Q		No	ClinGen gnomAD
rs1389025702 CA376041292	335	R>W		No	ClinGen gnomAD
TCGA novel	337	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA203301257 rs1047516977	339	E>D		No	ClinGen Ensembl
CA5412601 rs765968705	340	I>L		No	ClinGen ExAC gnomAD
CA5412600 rs755779249	340	I>T		No	ClinGen ExAC gnomAD
rs749867055 CA5412599	343	P>H		No	ClinGen ExAC gnomAD
rs190470029 CA203301248	345	Y>C		No	ClinGen 1000Genomes
rs761370935 CA5412597	348	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1299613623 CA376041070	359	K>N		No	ClinGen TOPMed
CA203301244 rs1802843	361	N>K		No	ClinGen Ensembl
rs141674998 CA5412596	361	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA5412595 rs555055285	362	R>C		No	ClinGen 1000Genomes ExAC gnomAD
CA376041046 rs1282359571	363	T>I		No	ClinGen TOPMed
TCGA novel	364	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1588529302 CA376041004	369	K>N		No	ClinGen Ensembl
CA376040977 rs1215326914	374	E>K		No	ClinGen gnomAD
CA5412590 rs777054688	376	A>T		No	ClinGen ExAC TOPMed gnomAD
rs771117192 CA5412589	376	A>V		No	ClinGen ExAC gnomAD
CA203301231 rs960274224	377	P>R		No	ClinGen TOPMed gnomAD
CA376040940 rs1387669773	380	A>S		No	ClinGen gnomAD
CA376040933 rs1347665387	381	T>A		No	ClinGen gnomAD
rs778103191 CA5412587	385	N>H		No	ClinGen ExAC TOPMed gnomAD
rs1463885235 CA376040895	385	N>T		No	ClinGen gnomAD
rs1419246556 CA376040860	388	P>L		No	ClinGen TOPMed gnomAD
rs1367263388 CA376040865	388	P>S		No	ClinGen TOPMed
CA5412586 rs772657582	389	G>R		No	ClinGen ExAC TOPMed gnomAD
CA376040851 rs1464499565	389	G>V		No	ClinGen gnomAD
rs1387249288 CA376040847	390	A>P		No	ClinGen TOPMed
TCGA novel	390	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with P49903

2 regional properties for P49903

Type	Name	Position	InterPro Accession
domain	PurM-like, C-terminal domain	193 - 367	IPR010918
domain	PurM-like, N-terminal domain	82 - 169	IPR016188

Functions

		Description
EC Number	2.7.9.3	Phosphotransferases with paired acceptors
Subcellular Localization	[Isoform 1]: Cell membrane ; Peripheral membrane protein Nucleus membrane ; Peripheral membrane protein ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

7 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GTP binding	Binding to GTP, guanosine triphosphate.
identical protein binding	Binding to an identical protein or proteins.
metal ion binding	Binding to a metal ion.
protein heterodimerization activity	Binding to a nonidentical protein to form a heterodimer.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
selenide, water dikinase activity	Catalysis of the reaction: ATP + H(2)O + hydrogen selenide = AMP + 3 H(+) + phosphate + selenophosphorate.

3 GO annotations of biological process

Name	Definition
phosphorylation	The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
protein modification process	The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
selenocysteine biosynthetic process	The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q0VC82	SEPHS1	Selenide, water dikinase 1	Bos taurus (Bovine)	PR
Q8BH69	Sephs1	Selenide, water dikinase 1	Mus musculus (Mouse)	PR
Q6GL12	sephs1	Selenide, water dikinase 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q7ZW38	sephs1	Selenide, water dikinase 1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MSTRESFNPE	SYELDKSFRL	TRFTELKGTG	CKVPQDVLQK	LLESLQENHF	QEDEQFLGAV
70	80	90	100	110	120
MPRLGIGMDT	CVIPLRHGGL	SLVQTTDYIY	PIVDDPYMMG	RIACANVLSD	LYAMGVTECD
130	140	150	160	170	180
NMLMLLGVSN	KMTDRERDKV	MPLIIQGFKD	AAEEAGTSVT	GGQTVLNPWI	VLGGVATTVC
190	200	210	220	230	240
QPNEFIMPDN	AVPGDVLVLT	KPLGTQVAVA	VHQWLDIPEK	WNKIKLVVTQ	EDVELAYQEA
250	260	270	280	290	300
MMNMARLNRT	AAGLMHTFNA	HAATDITGFG	ILGHAQNLAK	QQRNEVSFVI	HNLPVLAKMA
310	320	330	340	350	360
AVSKACGNMF	GLMHGTCPET	SGGLLICLPR	EQAARFCAEI	KSPKYGEGHQ	AWIIGIVEKG
370	380	390
NRTARIIDKP	RIIEVAPQVA	TQNVNPTPGA	TS