Q8BGV8
Gene name |
Mief1 (Mid51, Smcr7l) |
Protein name |
Mitochondrial dynamics protein MID51 |
Names |
Mitochondrial dynamics protein of 51 kDa homolog, Mitochondrial elongation factor 1, Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:239555 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for Q8BGV8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4OAF | X-ray | 220 A | A/B/C/D | 134-463 | PDB |
| 4OAG | X-ray | 200 A | A/B | 134-463 | PDB |
| 4OAH | X-ray | 200 A | A/B/C/D | 134-463 | PDB |
| 4OAI | X-ray | 200 A | Z | 134-463 | PDB |
| AF-Q8BGV8-F1 | Predicted | AlphaFoldDB |
12 variants for Q8BGV8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389377312 | 56 | A>S | No | EVA | |
| rs3406432039 | 161 | A>S | No | EVA | |
| rs3413117669 | 184 | M>I | No | EVA | |
| rs3389367324 | 206 | V>I | No | EVA | |
| rs3389384089 | 217 | C>Y | No | EVA | |
| rs3389380524 | 224 | I>S | No | EVA | |
| rs3389343243 | 246 | S>C | No | EVA | |
| rs3389390039 | 287 | I>F | No | EVA | |
| rs3389384010 | 291 | P>L | No | EVA | |
| rs3389294721 | 326 | R>K | No | EVA | |
| rs3389384136 | 414 | G>E | No | EVA | |
| rs3389371732 | 434 | L>R | No | EVA |
No associated diseases with Q8BGV8
1 regional properties for Q8BGV8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Mab-21-like, HhH/H2TH-like domain | 359 - 446 | IPR046906 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial large ribosomal subunit | The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). |
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| mitochondrial outer membrane | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ADP binding | Binding to ADP, adenosine 5'-diphosphate. |
| GDP binding | Binding to GDP, guanosine 5'-diphosphate. |
| identical protein binding | Binding to an identical protein or proteins. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to hypoxia | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. |
| mitochondrial fission | The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. |
| positive regulation of mitochondrial fission | Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. |
| positive regulation of mitochondrial translation | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion. |
| positive regulation of protein targeting to membrane | Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9NQG6 | MIEF1 | Mitochondrial dynamics protein MID51 | Homo sapiens (Human) | PR |
| Q5NCS9 | Mief2 | Mitochondrial dynamics protein MID49 | Mus musculus (Mouse) | PR |
| Q5XIS8 | Mief1 | Mitochondrial dynamics protein MID51 | Rattus norvegicus (Rat) | PR |
| Q52MA5 | mief1 | Mitochondrial dynamics protein MID51 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGAGERKGK | KDDNGIGTAI | DFVLSNARLV | LGVGGAAMLG | IATLAVKRMY | DRAISAPTSP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TRLSHSGKRS | WEEPNWMGSP | RLLNKDMKAG | LSRSLQTLPT | DSSAFDTDTF | CPPRPKPLAR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RGQVDLKKSR | LRMSLQEKLL | SYYRNRAAIP | AGEQARAKQA | AVDICAELRS | FLRAKLPDMP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LRDMYLSGSL | YDDLQVVTAD | HIQLIVPLVL | EQNLWSCIPG | EDTIMNVPGF | FLVRRENPEY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FPRGSSYWDR | CVVGGYLSPK | TVADTFEKVV | AGSINWPAIG | SLLDYVIRPA | PPPEALTLEV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QYEKDKHLVI | DFLPSVTLGD | TVLVARPHRL | AQYDNLWRLS | LRPAETARLR | ALDQADSGCR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SLCLKILKAI | CKSTPALGHL | TASQLTNVIL | HLAQEEADWS | PDMLADRFLQ | ALRGLISYLE |
| 430 | 440 | 450 | 460 | ||
| AGVLPSALNP | KVNLFAELTP | QEIDELGYTL | YCSLSEPEVL | LQT |