Q5XIS8

PR
Gene name
Mief1 (Mid51, Smcr7l)
Protein name
Mitochondrial dynamics protein MID51
Names
Mitochondrial dynamics protein of 51 kDa homolog, Mitochondrial elongation factor 1, Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:315141
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-187 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5XIS8

Entry ID Method Resolution Chain Position Source
AF-Q5XIS8-F1 Predicted AlphaFoldDB

1 variants for Q5XIS8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs8149738 454 L>F No EVA

No associated diseases with Q5XIS8

1 regional properties for Q5XIS8

Type Name Position InterPro Accession
domain Mab-21-like, HhH/H2TH-like domain 359 - 446 IPR046906

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion outer membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial large ribosomal subunit The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
ADP binding Binding to ADP, adenosine 5'-diphosphate.
GDP binding Binding to GDP, guanosine 5'-diphosphate.
identical protein binding Binding to an identical protein or proteins.

5 GO annotations of biological process

Name Definition
cellular response to hypoxia Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
mitochondrial fission The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
positive regulation of mitochondrial fission Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
positive regulation of mitochondrial translation Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.
positive regulation of protein targeting to membrane Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9NQG6 MIEF1 Mitochondrial dynamics protein MID51 Homo sapiens (Human) PR
Q8BGV8 Mief1 Mitochondrial dynamics protein MID51 Mus musculus (Mouse) PR
Q5NCS9 Mief2 Mitochondrial dynamics protein MID49 Mus musculus (Mouse) PR
Q52MA5 mief1 Mitochondrial dynamics protein MID51 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MAGAGERKGK KDDNGIGTAI DFVLSNARLV LGVGGAAMLG IATLAVKRMY DRAISAPTSP
70 80 90 100 110 120
TRLSHSGKRS WEEPNWMGSP RLLNRDMKTG LSRSLQTLPT DSSAFDTDTF CPPRPKPLAR
130 140 150 160 170 180
RGQVDLKKSR LRMSLQEKLL SYYRNRAAIP AGEQARAKQA AVDICAELRS FLRAKLPDMP
190 200 210 220 230 240
LRDMYLSGSL YDDLQVVTAD HIQLIVPLVL EQNLWSCIPG EDTIMNIPGF FLVRRENPEY
250 260 270 280 290 300
FPRGSSYWDR CVVGGYLSPK TVADTFEKVV AGSINWPAIG SLLDYVIRPA PPPEALTLEV
310 320 330 340 350 360
QYERDKHLVI DFLPSVTLGD TVLVARPHRL AQYDNLWRLS LRPAETARLR ALDQADSGCR
370 380 390 400 410 420
SLCLKILKAI CKSTPALGHL TASQLTNVIL HLSQEEADWS PDMLADRFLQ ALRGLISYLE
430 440 450 460
AGVLPSALNP KVNLFAELTP HEIDELGYTL YCSLSEPEVL LQT