Q5NCS9
Gene name |
Mief2 (Gm11, Mid49, Smcr7) |
Protein name |
Mitochondrial dynamics protein MID49 |
Names |
Mitochondrial dynamics protein of 49 kDa homolog, Mitochondrial elongation factor 2, Smith-Magenis syndrome chromosomal region candidate gene 7 protein homolog |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:237781 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q5NCS9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4WOY | X-ray | 240 A | A/B | 126-454 | PDB |
| AF-Q5NCS9-F1 | Predicted | AlphaFoldDB |
28 variants for Q5NCS9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs213407099 | 12 | S>G | No | EVA | |
| rs3389134657 | 17 | L>R | No | EVA | |
| rs230526674 | 18 | G>D | No | EVA | |
| rs247856155 | 19 | S>N | No | EVA | |
| rs3389151147 | 42 | I>V | No | EVA | |
| rs3389126615 | 80 | Q>K | No | EVA | |
| rs3389166050 | 81 | K>R | No | EVA | |
| rs243921678 | 94 | A>V | No | EVA | |
| rs48849346 | 113 | T>M | No | EVA | |
| rs50494244 | 117 | F>L | No | EVA | |
| rs223558500 | 118 | S>N | No | EVA | |
| rs26972009 | 120 | I>V | No | EVA | |
| rs3389162552 | 127 | F>I | No | EVA | |
| rs26972008 | 129 | E>D | No | EVA | |
| rs3389151146 | 163 | Y>* | No | EVA | |
| rs3389157727 | 170 | E>V | No | EVA | |
| rs3389157704 | 174 | G>R | No | EVA | |
| rs3389162527 | 193 | H>Q | No | EVA | |
| rs3389171321 | 270 | A>V | No | EVA | |
| rs242141914 | 363 | I>F | No | EVA | |
| rs242141914 | 363 | I>V | No | EVA | |
| rs3389134728 | 377 | H>N | No | EVA | |
| rs3402400726 | 379 | T>LS* | No | EVA | |
| rs3389134741 | 381 | V>L | No | EVA | |
| rs3389134741 | 381 | V>M | No | EVA | |
| rs3389165043 | 382 | V>A | No | EVA | |
| rs3389166075 | 387 | E>K | No | EVA | |
| rs3389126624 | 398 | G>V | No | EVA |
No associated diseases with Q5NCS9
1 regional properties for Q5NCS9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Mab-21-like, HhH/H2TH-like domain | 376 - 439 | IPR046906 |
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial outer membrane | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| dynamin family protein polymerization involved in mitochondrial fission | The process of creating dynamin protein family polymers, compounds composed of a large number of dynamin family monomers around a lipid tube of a dividing mitochondrion. Dynamin polymers form around lipid tubes and contribute to membrane fission. |
| mitochondrion organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. |
| positive regulation of mitochondrial fission | Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. |
| positive regulation of protein targeting to membrane | Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. |
| regulation of mitochondrion organization | Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEFSQKQRK | QSGSEGLGSV | VDFLLANARL | VLGVGGAAVL | GIATLAVKRL | IDRATSPPDE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DDTKGDSWKE | LSLLRATSPQ | KPQPPPAAFS | QPLATGSPSP | SVPVEPTPIH | SPTTPKFSTI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| APLCLTFQER | LLAFERKHVI | TPEAHVTLAK | QLAGDIALEL | QAYLRSKFPE | LPFGALVPGG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PLYDGLQAGT | AEHVRLLAPL | ELEPGLWSLV | PGVDTVAREP | RCWAVRRTQL | EFHPRGCSPW |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DRFLVGGYLS | SRVLLELLRK | ALSASVNWPA | IGSLLGCLIW | PDVASEELLL | KVQHECLEFT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LAVLMVVPGA | STDDRLLLAW | PLEGLASNLW | LQDLYPVETA | RLRALDDQDA | GTRRRLLLLL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| CGICRGHPAL | VRLGWSHLTQ | VVLHLGEEEV | AWTEEALGER | FLQALEFLVG | SLEQASLPCH |
| 430 | 440 | 450 | |||
| FNPSVNLLGN | FREEEIDDIG | YVLYSGLQVP | ESLF |