AiPD: Autoinhibited Protein Database

Q86V40

Gene name	TRABD2A (C2orf89, TIKI1)
Protein name	Metalloprotease TIKI1
Names	TRAB domain-containing protein 2A
Species	Homo sapiens (Human)
KEGG Pathway	hsa:129293
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-71 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-71 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q86V40

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q86V40-F1	Predicted				AlphaFoldDB

462 variants for Q86V40

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA1738276 rs752929545	4	W>*		No	ClinGen ExAC TOPMed gnomAD
CA347451290 rs1430944901	6	W>S		No	ClinGen gnomAD
rs1322231811 CA347451264	7	F>L		No	ClinGen TOPMed
rs1362772331 CA347451211	10	Q>K		No	ClinGen TOPMed
CA347451167 rs1199631258	12	L>F		No	ClinGen TOPMed gnomAD
rs778888179 CA1738275	14	L>R		No	ClinGen ExAC gnomAD
rs1313417996 CA347451123	15	L>P		No	ClinGen TOPMed
rs750372380 CA347451085	17	T>K		No	ClinGen ExAC TOPMed gnomAD
CA1738273 rs750372380	17	T>M		No	ClinGen ExAC TOPMed gnomAD
CA347451042 rs1465031796	19	A>V		No	ClinGen TOPMed
CA51664209 rs1054146476	20	A>D		No	ClinGen Ensembl
rs751405880 CA1738270	21	S>*		No	ClinGen ExAC gnomAD
rs1264171835 CA347451005	22	R>Q		No	ClinGen gnomAD
rs1223096244 CA347450999	23	R>C		No	ClinGen TOPMed gnomAD
rs1223096244 CA347451000	23	R>G		No	ClinGen TOPMed gnomAD
CA1738269 rs763918643	24	G>E		No	ClinGen ExAC gnomAD
CA51664204 rs935802556 CA347450974	24	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen gnomAD NCI-TCGA
CA347450932 rs1432836087	26	P>S		No	ClinGen gnomAD
CA1738265 rs759052762	27	G>A		No	ClinGen ExAC TOPMed gnomAD
CA51664194 rs759052762	27	G>D		No	ClinGen ExAC TOPMed gnomAD
CA1738266 rs764670036	27	G>R		No	ClinGen ExAC gnomAD
CA347450901 rs1171899465	28	T>A		No	ClinGen gnomAD
CA347450849 rs1428637225	30	N>I		No	ClinGen gnomAD
rs747492693 CA1738262	31	C>*		No	ClinGen ExAC gnomAD
CA347450819 rs1187175578	32	E>G		No	ClinGen gnomAD
CA347450826 rs1431974747	32	E>K		No	ClinGen TOPMed
CA347450811 rs1463078864	33	L>V		No	ClinGen gnomAD
CA1738261 rs567498576	34	K>N		No	ClinGen 1000Genomes ExAC TOPMed
TCGA novel	35	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1738259 rs748338540	36	Q>H		No	ClinGen ExAC gnomAD
rs765010091 CA1738248	38	S>N		No	ClinGen ExAC TOPMed gnomAD
CA347448576 rs759252203	38	S>R		No	ClinGen ExAC TOPMed gnomAD
rs372746235 CA347448555	39	E>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA1738245 rs372746235	39	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA1738246 rs372746235	39	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	45	W>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347448402 rs1472112782	47	I>M		No	ClinGen gnomAD
CA51657973 rs965691003	48	K>E		No	ClinGen TOPMed gnomAD
rs773717756 CA1738243	48	K>R		No	ClinGen ExAC gnomAD
rs773717756 CA347448390	48	K>T		No	ClinGen ExAC gnomAD
rs772334677 CA1738242	49	R>*		No	ClinGen ExAC TOPMed gnomAD
CA347448351 rs1249973107	49	R>Q		No	ClinGen gnomAD
rs911621956 CA51657959	50	D>E		No	ClinGen TOPMed
rs1224779099 CA347448340	50	D>N		No	ClinGen gnomAD
CA347448307 rs1444424358	51	P>L		No	ClinGen TOPMed
rs985937809 CA51657944	52	P>S		No	ClinGen Ensembl
rs564057599 CA347448260	53	S>F		No	ClinGen 1000Genomes ExAC gnomAD
CA1738241 rs564057599	53	S>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA347448091 rs1334768912	59	I>N		No	ClinGen gnomAD
CA1738239 rs768924111	59	I>V		No	ClinGen ExAC gnomAD
rs749481202 COSM723041 CA1738238 COSM723042	60	H>R	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA347448030 rs1345549040	61	V>A		No	ClinGen gnomAD
rs746934612 CA1738235	62	P>L		No	ClinGen ExAC TOPMed gnomAD
CA1738236 rs746934612	62	P>R		No	ClinGen ExAC TOPMed gnomAD
CA347448024 rs1301991772	62	P>S		No	ClinGen TOPMed gnomAD
rs1301991772 CA347448028	62	P>T		No	ClinGen TOPMed gnomAD
TCGA novel	63	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347448017 rs1159505639	63	Y>D		No	ClinGen gnomAD
CA347447960 COSM443305 rs1201801674 COSM443306	65	R>*	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
COSM1023311 CA347447955 rs1480905437 COSM1023312	65	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA347447944 rs1196866588	66	V>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA347447911 rs1449769112	67	W>*		No	ClinGen gnomAD
rs375070443 CA1738230	72	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA347447769 rs1212280502	73	N>K		No	ClinGen TOPMed
rs1559098677 CA347447771	73	N>S		No	ClinGen Ensembl
CA1738229 rs753504438	74	S>F		No	ClinGen ExAC gnomAD
TCGA novel	75	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347447733 rs1573954573	75	K>R		No	ClinGen Ensembl
CA347447723 rs1273710658	76	E>Q		No	ClinGen TOPMed gnomAD
CA347447645 rs1390762657	78	F>L		No	ClinGen gnomAD
rs766012570 CA1738228	79	L>Q		No	ClinGen ExAC gnomAD
CA1738227 rs760207228	80	Q>*		No	ClinGen ExAC gnomAD
CA347447581 rs1573954544	82	S>R		No	ClinGen Ensembl
CA347447529 rs1386821649	84	V>A		No	ClinGen gnomAD
rs1386821649 CA347447527	84	V>G		No	ClinGen gnomAD
rs750901575 CA1738226	84	V>L		No	ClinGen ExAC gnomAD
TCGA novel	85	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA51657878 rs868277440	90	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA51657867 rs956583702	93	P>L		No	ClinGen Ensembl
CA347447245 rs1428913423	93	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA347447243 rs1428913423	93	P>T		No	ClinGen TOPMed gnomAD
CA1738224 rs762214231	95	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1573954490 CA347447192	95	T>P		No	ClinGen Ensembl
rs768969052 CA1738222	96	I>T		No	ClinGen ExAC gnomAD
rs372045788 CA1738220	97	S>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA1738219 rs769865987	97	S>L		No	ClinGen ExAC gnomAD
CA1738217 rs368828547	98	A>V		No	ClinGen ESP ExAC gnomAD
rs1277559741 CA347447134	99	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA347447062 rs1216955994	101	S>N		No	ClinGen TOPMed gnomAD
rs772091944 CA1738216	103	Q>H		No	ClinGen ExAC gnomAD
rs748001081 CA1738215	104	M>L		No	ClinGen ExAC TOPMed gnomAD
CA51657796 rs569958992	104	M>R		No	ClinGen Ensembl
rs375938439 CA1738214	106	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA347446844 rs1339076304	107	Q>R		No	ClinGen gnomAD
rs1453882568 CA347446803	108	G>D		No	ClinGen gnomAD
rs199658694 CA347446778	109	E>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1738212 rs199658694	109	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1738211 rs779788135	109	E>V		No	ClinGen ExAC gnomAD
CA347446742 rs1420271707	110	N>K		No	ClinGen gnomAD
CA347446719 rs1553515588	111	L>P		No	ClinGen Ensembl
rs1318787466 CA347446681	112	Q>H		No	ClinGen TOPMed
rs1388293888 CA347446655	114	V>M		No	ClinGen gnomAD
CA51657762 rs1046215165	115	L>F		No	ClinGen gnomAD
rs755718967 CA1738210	116	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1273035970 CA347446547	119	I>S		No	ClinGen gnomAD
rs1439223480 CA347446563	119	I>V		No	ClinGen gnomAD
rs1224866135 CA347446478	121	C>S		No	ClinGen TOPMed
rs766915408 CA1738208	122	R>C		No	ClinGen ExAC TOPMed gnomAD
CA1738206 rs371865663	122	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA1738207 rs371865663	122	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs763234862 CA1738204	125	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs763234862 CA347446028	125	R>G		No	ClinGen ExAC TOPMed gnomAD
rs775825438 CA1738203	125	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1355388121 CA347445972	128	E>A		No	ClinGen gnomAD
rs1481440828 CA347445943	129	Y>F		No	ClinGen TOPMed
rs574481991 CA1738201	129	Y>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA347445845 rs1165330715	133	M>T		No	ClinGen TOPMed gnomAD
rs1386812772 CA347445819	134	M>I		No	ClinGen TOPMed
rs556202044 CA1738199	134	M>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1738198 rs770881112	136	L>S		No	ClinGen ExAC gnomAD
CA347445764 rs1398787897	137	W>*		No	ClinGen TOPMed
rs748143391 CA1738197	138	M>I		No	ClinGen ExAC gnomAD
CA347445736 rs1297475504	139	T>N		No	ClinGen TOPMed
rs778940251 CA1738196	140	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1280743351 CA347445716	141	D>G		No	ClinGen TOPMed
rs749163938 CA1738194	142	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA1738192 rs192920683	143	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA347445685 rs192920683	143	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1863772 VAR_039920 CA1738191	143	R>H		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA1738193 rs192920683	143	R>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA347445678 rs756663672	144	G>R		No	ClinGen ExAC TOPMed gnomAD
CA1738189 COSM1735514 COSM1735515 rs756663672	144	G>S	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs377468049 CA1738188	145	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA347445659 rs1225875558	145	K>N		No	ClinGen gnomAD
CA51657580 rs953125551	146	G>R		No	ClinGen TOPMed
CA347445613 CA1738185 rs371560834	148	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA347445609 rs759830766	149	A>P		No	ClinGen ExAC TOPMed gnomAD
CA1738183 rs759830766	149	A>S		No	ClinGen ExAC TOPMed gnomAD
COSM1023307 COSM1023308 rs759830766 CA347445610	149	A>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	150	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347445570 rs1303867525	152	L>F		No	ClinGen gnomAD
CA1738182 rs375570199	152	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA347445530 rs1483160140	156	I>V		No	ClinGen gnomAD
CA51657543 rs372546193	158	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
rs760608183 CA1738180	160	W>*		No	ClinGen ExAC gnomAD
rs1030921559 CA51657532	161	E>G		No	ClinGen Ensembl
CA1738179 rs773422750	162	R>C		No	ClinGen ExAC TOPMed gnomAD
CA51657515 rs369195191	162	R>H		No	ClinGen ESP TOPMed gnomAD
CA347445385 rs768774262	164	R>K		No	ClinGen ExAC gnomAD
CA1738178 rs768774262	164	R>M		No	ClinGen ExAC gnomAD
CA1738176 CA347445377 rs775465259	164	R>S		No	ClinGen ExAC TOPMed gnomAD
CA347445386 rs1239855507	164	R>W		No	ClinGen TOPMed
CA1738174 rs745547340	166	V>A		No	ClinGen ExAC gnomAD
CA347445359 rs1244364513	166	V>I		No	ClinGen TOPMed
rs1573954078 CA347445299	168	V>G		No	ClinGen Ensembl
CA51657463 rs913092601	168	V>M		No	ClinGen TOPMed
rs1197700871 CA347445244	170	L>F		No	ClinGen TOPMed
rs1197700871 CA347445249	170	L>I		No	ClinGen TOPMed
rs1218370454 CA347445193	172	V>I		No	ClinGen gnomAD
rs1483913476 CA347445145	173	N>I		No	ClinGen TOPMed gnomAD
rs1267898861 CA347445100	175	L>V		No	ClinGen gnomAD
CA347445060 rs1238239433	176	T>I		No	ClinGen TOPMed gnomAD
CA347444997 rs1283976196	180	I>F		No	ClinGen gnomAD
rs1386320624 CA347444995	180	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs10221703 CA1738169	181	K>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1738168 rs753158730	182	S>Y		No	ClinGen ExAC gnomAD
rs373573108 COSM1409752 CA1738167 COSM1409753	183	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA1738166 rs755242934	183	R>H		No	ClinGen ExAC gnomAD
rs1158182613 CA347444880	185	V>A		No	ClinGen gnomAD
rs1367858566 CA347444899	185	V>L		No	ClinGen TOPMed
CA347444824 rs1363296155	187	V>A		No	ClinGen Ensembl
rs766579273 CA1738164 COSM443304 COSM443303	188	L>V	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1176152097 CA347444754	190	L>M		No	ClinGen gnomAD
CA51657420 rs1013351320	190	L>P		No	ClinGen TOPMed
CA347444752 rs1176152097	190	L>V		No	ClinGen gnomAD
CA347444730 rs1354619926	191	F>S		No	ClinGen TOPMed gnomAD
CA347444677 rs1465769776	193	A>D		No	ClinGen gnomAD
CA1738162 rs773475876	193	A>S		No	ClinGen ExAC gnomAD
CA1738163 rs773475876	193	A>T		No	ClinGen ExAC gnomAD
rs1207279814 CA347444619	195	E>G		No	ClinGen gnomAD
rs376534684 CA1738160	196	A>G		No	ClinGen ESP ExAC gnomAD
rs979452131 CA51657365	197	E>K		No	ClinGen TOPMed gnomAD
CA51657324 rs201117229	198	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs201117229 CA1738158	198	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA1738159 rs372215440	198	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs776472472 CA1738156	202	Q>K		No	ClinGen ExAC gnomAD
TCGA novel	204	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1013852864 CA51657290	206	V>A		No	ClinGen TOPMed gnomAD
rs746631162 CA1738154	208	K>E		No	ClinGen ExAC gnomAD
CA1738153 rs777292838	208	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1356892398 CA347444270	211	E>G		No	ClinGen gnomAD
rs1288422637 CA347444219	212	Q>H		No	ClinGen gnomAD
rs1245250793 CA347444179	214	H>R		No	ClinGen TOPMed
rs748671507 CA1738151	217	N>K		No	ClinGen ExAC TOPMed gnomAD
rs1462461531 CA347444114	217	N>S		No	ClinGen TOPMed
CA1738150 rs779225828	218	G>R		No	ClinGen ExAC gnomAD
CA1738148 rs376411366	222	S>L		No	ClinGen ESP ExAC gnomAD
TCGA novel	225	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747726341 CA1738134	230	Q>E		No	ClinGen ExAC gnomAD
rs1253010312 CA347469204	230	Q>H		No	ClinGen gnomAD
TCGA novel	232	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1269902668 CA347469062	237	S>G		No	ClinGen gnomAD
rs1482737359 CA347469049	237	S>I		No	ClinGen gnomAD
CA51679070 rs562049467	239	R>*		No	ClinGen 1000Genomes TOPMed gnomAD
CA51679065 rs949463489	239	R>Q		No	ClinGen TOPMed gnomAD
CA347468986 rs1170014212	240	A>G		No	ClinGen TOPMed
rs778475837 CA1738133	242	S>G		No	ClinGen ExAC gnomAD
rs1387753572 CA347468934	242	S>N		No	ClinGen TOPMed
TCGA novel	243	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs953496474 CA51679050	243	L>P		No	ClinGen Ensembl
CA347468813 rs1338331944	245	I>N		No	ClinGen TOPMed gnomAD
rs1022495275 CA51679049	245	I>V		No	ClinGen TOPMed gnomAD
CA347468781 rs1308767109	246	P>L		No	ClinGen gnomAD
CA1738132 rs769094685	248	T>M		No	ClinGen ExAC TOPMed gnomAD
CA51679039 rs957212882	249	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs199710307 CA51679022	253	I>L		No	ClinGen TOPMed
rs1559088322 CA347468305	255	H>R		No	ClinGen Ensembl
rs1257914552 CA347468324	255	H>Y		No	ClinGen TOPMed
CA1738130 rs780314322	256	Y>C		No	ClinGen ExAC gnomAD
rs1160098553 CA347468184	257	N>K		No	ClinGen TOPMed gnomAD
rs1365928605 CA347468207	257	N>T		No	ClinGen TOPMed gnomAD
CA51679015 rs550108794	258	C>*		No	ClinGen 1000Genomes TOPMed gnomAD
rs1031260886 CA51679017	258	C>G		No	ClinGen TOPMed gnomAD
CA347468161 rs1031260886	258	C>R		No	ClinGen TOPMed gnomAD
CA1738129 rs201711793	259	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1573928235 CA347468089	260	D>A		No	ClinGen Ensembl
rs1201744485 CA347468044	262	S>G		No	ClinGen gnomAD
rs750677479 CA1738128	264	V>I		No	ClinGen ExAC TOPMed gnomAD
CA347467986 rs750677479	264	V>L		No	ClinGen ExAC TOPMed gnomAD
rs1389808734 CA347467902	267	S>N		No	ClinGen TOPMed
rs1573928198 CA347467860	269	D>G		No	ClinGen Ensembl
rs1353920407 CA347467773	272	Q>*		No	ClinGen gnomAD
rs766171298 CA1738117	273	V>F		No	ClinGen ExAC gnomAD
TCGA novel	274	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347466626 rs1265923174	275	N>S		No	ClinGen gnomAD
rs1220614295 CA347466585	278	N>D		No	ClinGen gnomAD
rs551144289 CA1738116	279	A>D		No	ClinGen 1000Genomes ExAC gnomAD
CA347466564 rs1273765193	280	T>A		No	ClinGen gnomAD
rs768945773 CA1738115	280	T>M		No	ClinGen ExAC TOPMed gnomAD
CA1738114 rs771772126	281	L>P		No	ClinGen ExAC gnomAD
CA347466549 rs771772126	281	L>R		No	ClinGen ExAC gnomAD
rs761508378 CA1738113	285	E>V		No	ClinGen ExAC TOPMed gnomAD
rs367984664 CA1738112	286	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA1738111 rs768172575	286	R>H		No	ClinGen ExAC gnomAD
rs182569411 CA1738110	287	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1738109 rs776072229	289	A>T		No	ClinGen ExAC gnomAD
rs1170915148 CA347466415	290	Q>R		No	ClinGen gnomAD
rs926638226 CA51677269	291	E>A		No	ClinGen Ensembl
CA347466383 rs1392023358	291	E>D		No	ClinGen gnomAD
CA347466360 rs1249347070	293	D>N		No	ClinGen TOPMed gnomAD
rs770420366 CA1738107	297	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1553512999 CA1738105	297	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs770420366 CA347466266	297	R>S		No	ClinGen ExAC TOPMed gnomAD
CA1738103 rs781671841	298	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA1738104 rs200113032	298	R>W		No	ClinGen ExAC TOPMed gnomAD
CA1738102 rs757590755	299	E>K		No	ClinGen ExAC gnomAD
rs777734196 CA1738100	301	I>T		No	ClinGen ExAC TOPMed gnomAD
rs758442653 CA1738099	302	Y>C		No	ClinGen ExAC gnomAD
CA347466197 rs1344927294	302	Y>H		No	ClinGen TOPMed gnomAD
rs753727587 CA1738098	303	K>R		No	ClinGen ExAC TOPMed gnomAD
CA347466152 rs1286351398	304	R>Q		No	ClinGen TOPMed gnomAD
rs372399132 CA1738096	304	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA347466133 rs1573925886	305	N>K		No	ClinGen Ensembl
rs1480741214 CA347466106	307	R>T		No	ClinGen TOPMed
CA1738095 COSM221951 rs750270376	309	G>E	Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA51677223 rs368275803	309	G>R		No	ClinGen ESP TOPMed gnomAD
TCGA novel	310	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA51677215 rs200442046	311	R>Q		No	ClinGen 1000Genomes gnomAD
CA1738094 rs201653074	311	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA1738093 rs761405072	312	V>G		No	ClinGen ExAC gnomAD
CA347465984 rs1169070832	313	K>R		No	ClinGen gnomAD
rs762589492 CA1738090	316	L>*		No	ClinGen ExAC TOPMed gnomAD
rs775127079 CA1738089	317	E>K		No	ClinGen ExAC gnomAD
CA1738087 rs746344377	319	F>L		No	ClinGen ExAC gnomAD
CA1738086 rs200693523	321	D>E		No	ClinGen ExAC TOPMed gnomAD
CA347465778 rs1274734832	321	D>G		No	ClinGen TOPMed gnomAD
CA347465720 rs1346467929	323	G>V		No	ClinGen TOPMed
CA1738085 rs771276167	325	F>L		No	ClinGen ExAC TOPMed gnomAD
CA347465634 rs1355897093	327	A>D		No	ClinGen gnomAD
rs1229319408 CA347465641	327	A>T		No	ClinGen gnomAD
CA347465620 rs1281993188	328	F>I		No	ClinGen TOPMed
CA51677186 rs867852406	329	G>E		No	ClinGen Ensembl
CA347465559 rs1250921235	330	A>V		No	ClinGen TOPMed gnomAD
rs375925350 CA1738069	334	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs764797694 CA1738070	334	M>V		No	ClinGen ExAC TOPMed gnomAD
rs186398327 CA1738068	336	N>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA347462883 rs1302108804	336	N>K		No	ClinGen gnomAD
CA347462862 rs1219682029	337	N>S		No	ClinGen gnomAD
CA347462846 rs1300940688	338	T>P		No	ClinGen gnomAD
CA1738066 rs761171474	339	V>A		No	ClinGen ExAC gnomAD
TCGA novel	339	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA51672316 rs1017937797	343	L>S		No	ClinGen TOPMed gnomAD
CA1738063 rs772390100	344	R>Q		No	ClinGen ExAC TOPMed gnomAD
COSM1023303 CA1738064 rs773439589 COSM1023304	344	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA1738062 rs748342065	345	R>C		No	ClinGen ExAC TOPMed gnomAD
CA1738061 rs61744273	345	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1559084961 CA347462566	346	E>Q		No	ClinGen Ensembl
rs999003021 CA51672298	348	Y>C		No	ClinGen TOPMed
CA347462393 rs1190894957	349	E>D		No	ClinGen TOPMed gnomAD
rs60429698 CA347462283	352	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1738059 rs745818520	352	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1256638388 CA347462272	353	A>G		No	ClinGen gnomAD
CA1738057 rs201984217	353	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs751419080 CA1738056 COSM3714251 COSM3714252	357	R>*	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs777397968 CA1738055	357	R>Q	Variant assessed as Somatic; 4.642e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA1738053 rs752345840	359	I>V		No	ClinGen ExAC
CA1738035 rs770941195	362	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1559082656 CA347459988	363	K>N		No	ClinGen Ensembl
CA1738034 rs746880993	363	K>R		No	ClinGen ExAC gnomAD
CA1738033 rs777642902	364	S>I		No	ClinGen ExAC gnomAD
rs758205937 CA1738031	367	T>N		No	ClinGen ExAC gnomAD
CA347459920 rs1573913186	367	T>P		No	ClinGen Ensembl
rs778772598 CA1738029	368	S>F		No	ClinGen ExAC gnomAD
rs1573913170 CA347459898	368	S>P		No	ClinGen Ensembl
rs778772598 CA347459893	368	S>Y		No	ClinGen ExAC gnomAD
CA347459874 rs1250865288	369	T>R		No	ClinGen TOPMed
COSM3001437 COSM3001438 CA347459868 rs754667701	370	R>W	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA1738027 rs753450984	371	P>S		No	ClinGen ExAC gnomAD
rs761279625 CA1738025	373	L>P		No	ClinGen ExAC gnomAD
rs1573913122 CA347459804	374	S>P		No	ClinGen Ensembl
CA347459750 rs1460986421	376	I>T		No	ClinGen TOPMed
rs1573913099 CA347459732	377	F>V		No	ClinGen Ensembl
CA51666897 rs1022766469	380	K>E		No	ClinGen TOPMed
TCGA novel	380	K>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs373152672 CA1738022	380	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1293364540 CA347459665	381	V>I		No	ClinGen gnomAD
CA1738021 rs774694650	382	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1573913066 CA347459630	383	T>P		No	ClinGen Ensembl
CA347459606 rs1159985968	384	L>P		No	ClinGen gnomAD
CA347459599 rs1159985968	384	L>R		No	ClinGen gnomAD
CA347459591 rs1472273544	385	E>*		No	ClinGen gnomAD
rs1362142655 CA347459582	385	E>V		No	ClinGen gnomAD
rs1179520212 CA347459563	386	V>G		No	ClinGen gnomAD
TCGA novel rs1372405042 CA347459567	386	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen TOPMed NCI-TCGA
CA1738019 rs200678068	387	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200678068 CA347459550	387	P>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA347459554 rs200678068	387	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA347459557 rs1434861120	387	P>S		No	ClinGen gnomAD
CA347459524 rs769712825	389	P>L		No	ClinGen ExAC TOPMed gnomAD
CA1738017 rs769712825	389	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA347459526 rs769712825	389	P>R		No	ClinGen ExAC TOPMed gnomAD
CA1738015 rs772952387	390	E>D		No	ClinGen ExAC gnomAD
CA1738016 rs746976616	390	E>K		No	ClinGen ExAC TOPMed gnomAD
rs549570443 CA1738014	391	A>S		No	ClinGen ExAC gnomAD
rs549570443 CA51666862	391	A>T		No	ClinGen ExAC gnomAD
rs1332221426 CA347459468	392	V>E		No	ClinGen gnomAD
COSM1023299 rs560540640 COSM1023300 CA1738012	392	V>I	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
rs560540640 CA347459476	392	V>L		No	ClinGen 1000Genomes ExAC gnomAD
CA347459429 rs1439235000	394	S>*		No	ClinGen gnomAD
CA347459395 rs1456941112	396	H>N		No	ClinGen gnomAD
CA1738009 rs755523009	396	H>Q		No	ClinGen ExAC gnomAD
COSM1198757 rs750944359 COSM1198758 CA1738007	398	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1573912926 CA347459348	398	T>P		No	ClinGen Ensembl
CA1738006 rs368838929	401	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs548830847 COSM1738697 CA1738005 COSM1738698	402	L>I	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs548830847 CA1738004	402	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1738002 rs763184555	403	V>A		No	ClinGen ExAC gnomAD
CA1738003 rs764402682	403	V>M		No	ClinGen ExAC gnomAD
TCGA novel	404	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA51666813 rs933687100	404	S>Y		No	ClinGen TOPMed
rs530598165 CA1738000	405	R>G		No	ClinGen 1000Genomes ExAC gnomAD
rs776756226 CA1737999	405	R>L		No	ClinGen ExAC TOPMed gnomAD
rs776756226 CA1737998	405	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA1738001 rs530598165	405	R>W		No	ClinGen 1000Genomes ExAC gnomAD
CA1737995 rs748069511	411	T>M		No	ClinGen ExAC gnomAD
rs1573912834 CA347459177	412	P>A		No	ClinGen Ensembl
CA347459173 rs1232751457	412	P>R		No	ClinGen TOPMed gnomAD
rs768526960 CA1737993	415	A>T		No	ClinGen ExAC TOPMed gnomAD
rs745429009 COSM443297 CA1737989 COSM443298	416	E>K	Variant assessed as Somatic; 0.0 impact. endometrium breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs745429009 CA1737990	416	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs780648523 CA1737988	418	R>S		No	ClinGen ExAC TOPMed
rs1336237919 CA347459089	419	F>I		No	ClinGen TOPMed gnomAD
rs757790660 CA347459068	420	R>L		No	ClinGen ExAC TOPMed gnomAD
CA1737986 rs757790660	420	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA347459072 COSM1409750 rs1401600406 COSM1409751	420	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1432816119 CA347459064	421	K>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA1737985 rs752012849	421	K>N		No	ClinGen ExAC gnomAD
rs562954319 CA1737983	423	R>P		No	ClinGen 1000Genomes ExAC gnomAD
CA1737984 rs562954319	423	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA347459034 rs1169030057	423	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA347459015 rs202220791	425	R>G		No	ClinGen ExAC TOPMed gnomAD
rs544748549 CA1737981	425	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
COSM3408011 COSM3408012 CA1737982 rs202220791	425	R>W	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA1737978 rs200243150	427	Q>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1737979 rs200243150	427	Q>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs2288352 CA1737976	428	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs2288352 CA1737975 VAR_039921	428	R>Q		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs550709902 CA1737977	428	R>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	429	R>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
VAR_039922 CA1737974 rs1649292	430	P>L		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP
COSM1409748 CA1737971 COSM1409749 rs61744733	431	R>*	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA1737969 rs770369663	431	R>P		No	ClinGen ExAC TOPMed gnomAD
CA1737970 rs770369663	431	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA347458896 rs1337681048	432	L>F		No	ClinGen gnomAD
rs778315280 CA347458878	433	R>L		No	ClinGen ExAC TOPMed gnomAD
CA347458879 rs778315280	433	R>P		No	ClinGen ExAC TOPMed gnomAD
CA1737967 rs778315280	433	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
COSM443295 rs747516201 COSM443296 CA1737968	433	R>W	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs758923721 CA1737966	435	F>Y		No	ClinGen ExAC gnomAD
rs374760126 CA1737965	436	S>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs570295886 CA51666635	437	D>A		No	ClinGen TOPMed gnomAD
CA347458777 rs755189333	437	D>H		No	ClinGen ExAC gnomAD
CA1737963 COSM1409746 COSM1409747 rs755189333	437	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA347458776 rs755189333	437	D>Y		No	ClinGen ExAC gnomAD
CA51666633 rs370369490	438	L>M		No	ClinGen ESP gnomAD
CA347458736 rs1417138142	439	W>R		No	ClinGen gnomAD
rs1573912623 CA347458690	440	V>G		No	ClinGen Ensembl
CA1737962 rs181451822	441	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM1198759 CA1737960 COSM1198760 rs377499574	441	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA1737961 rs377499574	441	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA347458662 rs377499574	441	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs1006038192 CA51666617	442	L>Q		No	ClinGen Ensembl
CA347458633 rs1158860978	443	E>K		No	ClinGen TOPMed
CA1737959 rs750526359	445	S>N		No	ClinGen ExAC gnomAD
rs750581584 CA1737942	446	D>E		No	ClinGen ExAC gnomAD
rs544959323 CA1737943	446	D>G		No	ClinGen 1000Genomes ExAC
rs1412069273 CA347457366	447	I>T		No	ClinGen TOPMed gnomAD
rs377242955 CA1737941	447	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	448	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758288319 CA1737940	449	P>L		No	ClinGen ExAC TOPMed gnomAD
rs758288319 CA51665579	449	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs1421968684 CA347457277	451	L>F		No	ClinGen TOPMed
CA51665572 rs1028542082	453	V>F		No	ClinGen TOPMed
CA51665563 rs962250323	456	L>P		No	ClinGen Ensembl
rs1222857290 CA347457076	457	D>G		No	ClinGen gnomAD
CA347457036 rs1468194424	458	R>W		No	ClinGen gnomAD
CA347457001 rs1271443426	459	H>Y		No	ClinGen gnomAD
CA347456967 rs1329892341	460	I>F		No	ClinGen gnomAD
CA347456944 rs1188396550	461	S>Y		No	ClinGen gnomAD
CA51665555 rs1008969235	462	T>S		No	ClinGen TOPMed gnomAD
CA347456895 rs773762140	465	R>G		No	ClinGen ExAC TOPMed gnomAD
rs559465733 CA1737936	465	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA51665521 rs559465733	465	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1737937 rs773762140	465	R>W		No	ClinGen ExAC TOPMed gnomAD
rs766066623 CA1737935	466	L>I		No	ClinGen ExAC gnomAD
rs1400754089 CA347456860	467	P>S		No	ClinGen TOPMed
CA1737934 rs770565102	468	R>C		No	ClinGen ExAC TOPMed gnomAD
CA1737933 rs772631869	468	R>H		No	ClinGen ExAC gnomAD
rs76277344 CA1737932	469	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1737931 rs199868738	469	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA347456809 rs1216810598	470	G>R		No	ClinGen TOPMed
CA347456785 rs1157792868	471	H>N		No	ClinGen gnomAD
CA1737930 rs371054600	472	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA347456749 rs1277808718	472	S>T		No	ClinGen TOPMed
rs1427938981 CA347456731	473	H>Y		No	ClinGen gnomAD
rs892519800 CA347456719	474	H>D		No	ClinGen TOPMed gnomAD
CA51665500 rs892519800	474	H>N		No	ClinGen TOPMed gnomAD
CA1737929 rs377717113	476	Q>*		No	ClinGen ESP ExAC gnomAD
CA347456633 rs1573910956	477	M>R		No	ClinGen Ensembl
CA1737928 rs749729117	479	A>V		No	ClinGen ExAC
rs1199827751 CA347456580	481	S>G		No	ClinGen TOPMed
CA347456554 rs1573910932	482	A>P		No	ClinGen Ensembl
rs374350995 CA1737927	482	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs756446721 CA1737926	486	L>V		No	ClinGen ExAC TOPMed gnomAD
rs746036602 CA1737925	490	V>M		No	ClinGen ExAC
CA1737924 rs781144232	491	F>V		No	ClinGen ExAC gnomAD
CA51665443 rs926454222	495	V>E		No	ClinGen TOPMed gnomAD
rs751587281 CA1737922	495	V>M		No	ClinGen ExAC gnomAD
CA347456296 rs1301005675	496	L>Q		No	ClinGen gnomAD
rs765273481 CA1737921	503	P>H		No	ClinGen ExAC
rs1436800397 CA347456149	503	P>S		No	ClinGen gnomAD
rs754883629 CA1737920	504	L>P		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with Q86V40

No regional properties for Q86V40

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q86V40

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
integral component of organelle membrane	The component of the organelle membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

4 GO annotations of molecular function

Name	Definition
endopeptidase activity	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
metal ion binding	Binding to a metal ion.
metalloendopeptidase activity	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Wnt-protein binding	Binding to a Wnt-protein, a secreted growth factor involved in signaling.

6 GO annotations of biological process

Name	Definition
head development	The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body.
negative regulation of Wnt signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
positive regulation of protein oxidation	Any process that activates or increases the frequency, rate or extent of protein oxidation.
positive regulation of protein-containing complex assembly	Any process that activates or increases the frequency, rate or extent of protein complex assembly.
proteolysis	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
Wnt signaling pathway	The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

5 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A6NFA1	TRABD2B	Metalloprotease TIKI2	Homo sapiens (Human)	PR
B1ATG9	Trabd2b	Metalloprotease TIKI2	Mus musculus (Mouse)	PR
F6PTN1	trabd2a	Metalloprotease TIKI1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
E7F4V6	trabd2b	Metalloprotease TIKI2	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
E7F6V0	trabd2a	Metalloprotease TIKI1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MSPWSWFLLQ	TLCLLPTGAA	SRRGAPGTAN	CELKPQQSEL	NSFLWTIKRD	PPSYFFGTIH
70	80	90	100	110	120
VPYTRVWDFI	PDNSKEAFLQ	SSIVYFELDL	TDPYTISALT	SCQMLPQGEN	LQDVLPRDIY
130	140	150	160	170	180
CRLKRHLEYV	KLMMPLWMTP	DQRGKGLYAD	YLFNAIAGNW	ERKRPVWVML	MVNSLTEVDI
190	200	210	220	230	240
KSRGVPVLDL	FLAQEAERLR	KQTGAVEKVE	EQCHPLNGLN	FSQVIFALNQ	TLLQQESLRA
250	260	270	280	290	300
GSLQIPYTTE	DLIKHYNCGD	LSSVILSHDS	SQVPNFINAT	LPPQERITAQ	EIDSYLRREL
310	320	330	340	350	360
IYKRNERIGK	RVKALLEEFP	DKGFFFAFGA	GHFMGNNTVL	DVLRREGYEV	EHAPAGRPIH
370	380	390	400	410	420
KGKSKKTSTR	PTLSTIFAPK	VPTLEVPAPE	AVSSGHSTLP	PLVSRPGSAD	TPSEAEQRFR
430	440	450	460	470	480
KKRRRSQRRP	RLRQFSDLWV	RLEESDIVPQ	LQVPVLDRHI	STELRLPRRG	HSHHSQMVAS
490	500
SACLSLWTPV	FWVLVLAFQT	ETPLL