E7F4V6

PR
Gene name
trabd2b (tiki2, si:ch211-120j21.1)
Protein name
Metalloprotease TIKI2
Names
TRAB domain-containing protein 2B
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:566028
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

331-518 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for E7F4V6

Entry ID Method Resolution Chain Position Source
AF-E7F4V6-F1 Predicted AlphaFoldDB

No variants for E7F4V6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for E7F4V6

No associated diseases with E7F4V6

No regional properties for E7F4V6

Type Name Position InterPro Accession
No domain, repeats, and functional sites for E7F4V6

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of organelle membrane The component of the organelle membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Wnt-protein binding Binding to a Wnt-protein, a secreted growth factor involved in signaling.

3 GO annotations of biological process

Name Definition
negative regulation of Wnt signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A6NFA1 TRABD2B Metalloprotease TIKI2 Homo sapiens (Human) PR
Q86V40 TRABD2A Metalloprotease TIKI1 Homo sapiens (Human) PR
B1ATG9 Trabd2b Metalloprotease TIKI2 Mus musculus (Mouse) PR
F6PTN1 trabd2a Metalloprotease TIKI1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
E7F6V0 trabd2a Metalloprotease TIKI1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MNCQSGLRWL VTLCAFFQVG SARDTHESTR QCDKPVSQKD MNSFLWTVKR PRPFPPSYLF
70 80 90 100 110 120
GTIHVPYTRV WDYIPESSKR AFQTSNSVFF ELDLTDPLTI SKLTSCQLLP NGENLQTLLP
130 140 150 160 170 180
RDLYRRLKRH LDYVKHMMPF WMTADQRGRG LYADYLFNAI AGNWERKRPV WVMLMVNSLT
190 200 210 220 230 240
EADVRSRGTP VLDLFLAQEA ERLGKQTGAV ERVEEQCHPL NGLNFSQVLF ALNQTLLQHE
250 260 270 280 290 300
SLRAGILQGT FTTEDLIAHY NCGDLNSIIF NHDTSQLPHF INSSLPDHER LTAQQIDSYL
310 320 330 340 350 360
RQELIYKRNE RMARRVSALL QRNPNQSFFF AFGAGHFLGN HSVLDILRQE GYEVEHTPPQ
370 380 390 400 410 420
EPIIQSWSER EATTLNPTED SFESVTEWTS ETPELEEISQ EELSHMLLPD SLSQLEEFGR
430 440 450 460 470 480
YKHPRKTHHT HSRPRLFSDL WVRIGDSTTP HPSIRITNGY VTVEPPQIRQ EQQQRLRERL
490 500 510
KPLSEPTNPS ALDSAAPNPT YALTCFLACL ISQLLFAS