B1ATG9
Gene name |
Trabd2b (Gm12824, Hkat, Tiki2) |
Protein name |
Metalloprotease TIKI2 |
Names |
Heart, kidney and adipose-enriched transmembrane protein, TRAB domain-containing protein 2B |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:666048 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B1ATG9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B1ATG9-F1 | Predicted | AlphaFoldDB |
18 variants for B1ATG9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3394843056 | 89 | T>S | No | EVA | |
| rs3388704683 | 113 | L>Q | No | EVA | |
| rs3394182607 | 122 | K>R | No | EVA | |
| rs3394676843 | 191 | A>V | No | EVA | |
| rs3412920150 | 240 | S>N | No | EVA | |
| rs3388696782 | 248 | E>* | No | EVA | |
| rs3388690392 | 250 | L>F | No | EVA | |
| rs3388700114 | 290 | I>F | No | EVA | |
| rs3388681193 | 313 | L>M | No | EVA | |
| rs3388700154 | 356 | A>V | No | EVA | |
| rs264255258 | 363 | V>A | No | EVA | |
| rs3388690386 | 366 | P>T | No | EVA | |
| rs3388690431 | 397 | T>I | No | EVA | |
| rs3394678795 | 436 | R>Q | No | EVA | |
| rs3388695189 | 453 | I>V | No | EVA | |
| rs3388704753 | 456 | P>S | No | EVA | |
| rs211994781 | 484 | A>P | No | EVA | |
| rs27514171 | 507 | A>V | No | EVA |
No associated diseases with B1ATG9
No regional properties for B1ATG9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for B1ATG9 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of organelle membrane | The component of the organelle membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| metalloendopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| Wnt-protein binding | Binding to a Wnt-protein, a secreted growth factor involved in signaling. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of Wnt signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway. |
| positive regulation of protein oxidation | Any process that activates or increases the frequency, rate or extent of protein oxidation. |
| positive regulation of protein-containing complex assembly | Any process that activates or increases the frequency, rate or extent of protein complex assembly. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
| Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q86V40 | TRABD2A | Metalloprotease TIKI1 | Homo sapiens (Human) | PR |
| A6NFA1 | TRABD2B | Metalloprotease TIKI2 | Homo sapiens (Human) | PR |
| F6PTN1 | trabd2a | Metalloprotease TIKI1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| E7F4V6 | trabd2b | Metalloprotease TIKI2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| E7F6V0 | trabd2a | Metalloprotease TIKI1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MHAALAGPLL | AALLATARAR | PQPPDGGQCR | PPGSQRDLNS | FLWTIRRHPP | AYLFGTIHVP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YTRVWDFIPD | NSKAAFQAST | HVYFELDLTD | PYTISALASC | QLLPHGENLQ | DVLPRELYWR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LKRHLDYVKL | MIPSWMTPAQ | RGKGLYADYL | FNAIAGNWER | KRPVWVMLMV | NSLTETDVRS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RGVPVLDLYL | AQQAEKMKKS | TGAVERVEEQ | CHPLNGLNFS | QVLFALNQTL | LQHESVRAGS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LQAPYTTEDL | IKHYNCGDLN | AVIFNHDTSQ | LPNFINTTLP | PHEQVTAQEI | DSYFRQELIY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KRNERMGKRV | MALLQENQDK | ICFFAFGAGH | FLGNNTVIDV | LRQAGLEVDH | TPAGQAIHGP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AAVGSPAPPP | EITSPASPAP | ATPAAAVPEA | TSATPTTPPE | EEDPVLSPHL | LLPDSLSQLE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EFGRQKWRKR | LNKHQRPRQF | NDLWVRIEDS | TTISPPPLPL | QPTPSSETTK | PFVKSSHQLQ |
| 490 | 500 | 510 | |||
| QQDAVGPTSS | SAPTLGLLHA | ITASIVAPFL | LHSLGPS |