Q86UX2

PR
Gene name
ITIH5 (KIAA1953, PP14776, UNQ311/PRO354)
Protein name
Inter-alpha-trypsin inhibitor heavy chain H5
Names
ITI heavy chain H5, ITI-HC5, Inter-alpha-inhibitor heavy chain 5
Species
Homo sapiens (Human)
KEGG Pathway
hsa:80760
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

605-685 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q86UX2

Entry ID Method Resolution Chain Position Source
AF-Q86UX2-F1 Predicted AlphaFoldDB

7 variants for Q86UX2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs12761771
VAR_042847
 139 E>K No UniProt
dbSNP
rs36056263
VAR_042848
 207 N>H No UniProt
dbSNP
rs36056263
VAR_055973
 421 N>H No UniProt
dbSNP
VAR_061276
rs35892621
 496 V>M No UniProt
dbSNP
rs2275069
VAR_042849
 570 T>P No UniProt
dbSNP
VAR_042850
rs34213756
 629 R>C No UniProt
dbSNP
rs10795551
VAR_055974
 925 F>S No UniProt
dbSNP

No associated diseases with Q86UX2

3 regional properties for Q86UX2

Type Name Position InterPro Accession
domain von Willebrand factor, type A 293 - 478 IPR002035
domain Inter-alpha-trypsin inhibitor heavy chain, C-terminal 716 - 909 IPR010600
domain VIT domain 35 - 161 IPR013694

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
collagen-containing extracellular matrix An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

1 GO annotations of molecular function

Name Definition
serine-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

1 GO annotations of biological process

Name Definition
hyaluronan metabolic process The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3T052 ITIH4 Inter-alpha-trypsin inhibitor heavy chain H4 Bos taurus (Bovine) PR
Q06033 ITIH3 Inter-alpha-trypsin inhibitor heavy chain H3 Homo sapiens (Human) PR
P79263 ITIH4 Inter-alpha-trypsin inhibitor heavy chain H4 Sus scrofa (Pig) PR
Q63416 Itih3 Inter-alpha-trypsin inhibitor heavy chain H3 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MLLLLGLCLG LSLCVGSQEE AQSWGHSSEQ DGLRVPRQVR LLQRLKTKPL MTEFSVKSTI
70 80 90 100 110 120
ISRYAFTTVS CRMLNRASED QDIEFQMQIP AAAFITNFTM LIGDKVYQGE ITEREKKSGD
130 140 150 160 170 180
RVKEKRNKTT EENGEKGTEI FRASAVIPSK DKAAFFLSYE ELLQRRLGKY EHSISVRPQQ
190 200 210 220 230 240
LSGRLSVDVN ILESAGIASL EVLPLHNSRQ RGSGRGEDDS GPPPSTVINQ NETFANIIFK
250 260 270 280 290 300
PTVVQQARIA QNGILGDFII RYDVNREQSI GDIQVLNGYF VHYFAPKDLP PLPKNVVFVL
310 320 330 340 350 360
DSSASMVGTK LRQTKDALFT ILHDLRPQDR FSIIGFSNRI KVWKDHLISV TPDSIRDGKV
370 380 390 400 410 420
YIHHMSPTGG TDINGALQRA IRLLNKYVAH SGIGDRSVSL IVFLTDGKPT VGETHTLKIL
430 440 450 460 470 480
NNTREAARGQ VCIFTIGIGN DVDFRLLEKL SLENCGLTRR VHEEEDAGSQ LIGFYDEIRT
490 500 510 520 530 540
PLLSDIRIDY PPSSVVQATK TLFPNYFNGS EIIIAGKLVD RKLDHLHVEV TASNSKKFII
550 560 570 580 590 600
LKTDVPVRPQ KAGKDVTGSP RPGGDGEGDT NHIERLWSYL TTKELLSSWL QSDDEPEKER
610 620 630 640 650 660
LRQRAQALAV SYRFLTPFTS MKLRGPVPRM DGLEEAHGMS AAMGPEPVVQ SVRGAGTQPG
670 680 690 700 710 720
PLLKKPYQPR IKISKTSVDG DPHFVVDFPL SRLTVCFNID GQPGDILRLV SDHRDSGVTV
730 740 750 760 770 780
NGELIGAPAP PNGHKKQRTY LRTITILINK PERSYLEITP SRVILDGGDR LVLPCNQSVV
790 800 810 820 830 840
VGSWGLEVSV SANANVTVTI QGSIAFVILI HLYKKPAPFQ RHHLGFYIAN SEGLSSNCHG
850 860 870 880 890 900
LLGQFLNQDA RLTEDPAGPS QNLTHPLLLQ VGEGPEAVLT VKGHQVPVVW KQRKIYNGEE
910 920 930 940
QIDCWFARNN AAKLIDGEYK DYLAFHPFDT GMTLGQGMSR EL