Q3T052

PR
Gene name
ITIH4
Protein name
Inter-alpha-trypsin inhibitor heavy chain H4
Names
ITI heavy chain H4, ITI-HC4, Inter-alpha-inhibitor heavy chain 4
Species
Bos taurus (Bovine)
KEGG Pathway
bta:513700
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3T052

Entry ID Method Resolution Chain Position Source
AF-Q3T052-F1 Predicted AlphaFoldDB

No variants for Q3T052

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3T052

No associated diseases with Q3T052

3 regional properties for Q3T052

Type Name Position InterPro Accession
domain von Willebrand factor, type A 273 - 458 IPR002035
domain Inter-alpha-trypsin inhibitor heavy chain, C-terminal 763 - 914 IPR010600
domain VIT domain 18 - 149 IPR013694

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

1 GO annotations of molecular function

Name Definition
serine-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

2 GO annotations of biological process

Name Definition
acute-phase response An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.
hyaluronan metabolic process The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q86UX2 ITIH5 Inter-alpha-trypsin inhibitor heavy chain H5 Homo sapiens (Human) PR
Q06033 ITIH3 Inter-alpha-trypsin inhibitor heavy chain H3 Homo sapiens (Human) PR
P79263 ITIH4 Inter-alpha-trypsin inhibitor heavy chain H4 Sus scrofa (Pig) PR
Q63416 Itih3 Inter-alpha-trypsin inhibitor heavy chain H3 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MKTPAPGRIH SIVLVLLSLA VLQTSKAQKV QNDIDIYSLT VDSKVSSRFA HTVITSRVVN
70 80 90 100 110 120
KADAVREATF QMELPKKAFI TNFSMVIDGV TYPGNIKEKA AAQEQYSAAV ARGESAGLVR
130 140 150 160 170 180
ATGRKTEQFQ VSVSVAPAAK VTFELVYEEL LARHLGAYEL LLKVRPQQLV KHLQMDIHIF
190 200 210 220 230 240
EPQGISFLET ESTFMTNKLA EALTTSQNKT KAHVRFKPTL SQQQKYPEKQ DTVIDGSFIV
250 260 270 280 290 300
RYDVDRPLSG GSIQIENGYF VHYFAPDSLS TIPKNVIFVI DKSGSMMGRK IKQTREALIK
310 320 330 340 350 360
ILDDLSPHDQ FDLISFSSEA TTWKPLLVPA STENVNEAKS YATGIQAQGG TNINDAMLMA
370 380 390 400 410 420
VQLLEKANQE ELLPEGSITL IILLTDGDPT VGETNPLNIQ KNVRKAINGQ HSLFCLGFGF
430 440 450 460 470 480
DVSYAFLEKM ALENGGLARR IYEDSDSALQ LQDFYQEVAN PLMTSVAFEY PSNAVESVTQ
490 500 510 520 530 540
DTFRVFFKGS ELVVAGKLRE QSPDVLLAQI RGQLHRENIT YMMMSHVAEQ EEMFRSPKYI
550 560 570 580 590 600
FHSFIERLWA YLTIQQLLEQ MVSALDAEKQ ALEARALSLS LSYSFVTPLT SMVITKPEGQ
610 620 630 640 650 660
EQSQVAEKPV EDESRGSRVY LGPMRFGHSV GDRTSRKPGG GLKLLNGTPL FGPPGPPAAA
670 680 690 700 710 720
SPFHRMTSRL VLPELMSPLA PASAPSPTSG PGGASHDTDF RIKGTTPTAL PFAPVQAPSV
730 740 750 760 770 780
ILPLPGQSVD RLCVDLRRPQ ELVNLLSDPD QGVEVTGHFE TAKARFSWIE VTFENPQVQI
790 800 810 820 830 840
HASPEHVVMT RNRRNSAYKW KETLYSVMPG LKVTMDKEGL LLLSRPDRVT IGLLFWDGPG
850 860 870 880 890 900
KGLRLLLQNT DRFSSHVSGT LGQFYQDVLW GPLDTADDSK RTLKVQGRDY SATRELKLDY
910
QESPPGKEIS CWSVEL