Q63416

PR
Gene name
Itih3
Protein name
Inter-alpha-trypsin inhibitor heavy chain H3
Names
ITI heavy chain H3, ITI-HC3, Inter-alpha-inhibitor heavy chain 3
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:50693
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

164-266 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q63416

Entry ID Method Resolution Chain Position Source
AF-Q63416-F1 Predicted AlphaFoldDB

4 variants for Q63416

Variant ID(s) Position Change Description Diseaes Association Provenance
rs13448573 153 E>K No EVA
rs13448657 210 G>E No EVA
rs13448211 417 R>G No EVA
rs13448214 477 L>V No EVA

No associated diseases with Q63416

3 regional properties for Q63416

Type Name Position InterPro Accession
domain von Willebrand factor, type A 282 - 467 IPR002035
domain Inter-alpha-trypsin inhibitor heavy chain, C-terminal 681 - 868 IPR010600
domain VIT domain 29 - 158 IPR013694

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

1 GO annotations of molecular function

Name Definition
serine-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

1 GO annotations of biological process

Name Definition
hyaluronan metabolic process The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3T052 ITIH4 Inter-alpha-trypsin inhibitor heavy chain H4 Bos taurus (Bovine) PR
Q86UX2 ITIH5 Inter-alpha-trypsin inhibitor heavy chain H5 Homo sapiens (Human) PR
Q06033 ITIH3 Inter-alpha-trypsin inhibitor heavy chain H3 Homo sapiens (Human) PR
P79263 ITIH4 Inter-alpha-trypsin inhibitor heavy chain H4 Sus scrofa (Pig) PR
10 20 30 40 50 60
MVTLWWPCLV LALLSGLETS GFPRSPLRLL GKRSLPEGVV DGIEIYSTKI SCKVTSRFAH
70 80 90 100 110 120
NVVTTRAVNR ADKAKEVSFD VELPKTAFIT NFTLTIDGVT YPGSVKEKEV AQKQYEKAVS
130 140 150 160 170 180
QGKTAGLVKA SGRKLEKFTV SVNVAAGSKV IFELTYEELL KRNKGKYEMY LKVQPKQLVR
190 200 210 220 230 240
HFEIDAHIFE PQGISMLDAD ASFITNDLLG SALTKSFSGK KGHVSFKPSL DQQRSCPTCT
250 260 270 280 290 300
DSLLNGDFTI VYDVNRESPG NVQIVNGYFV HFFAPQGLPV VPKNIAFVID VSGSMSGRKI
310 320 330 340 350 360
QQTREALLKI LDDMKEEDYL NFILFSTGVT TWKDHLVKAT PANLEEARAF VKNIRDRSMT
370 380 390 400 410 420
NINDGLLRGI EMLNKAREDH LVPERSTSIL VMLTDGDANT GESRPEKIQE NVRNAIRGKF
430 440 450 460 470 480
PLYNLGFGNN LNYNFLESLA LENHGFARRI YEDSDASLQL QGFYEEVANP LLTNVELEYP
490 500 510 520 530 540
ENAILDLTRN SYPHFYDGSE IVVAGRLVDR NVDNFKADVK GHGALNDLTF TEEVDMKEMD
550 560 570 580 590 600
AALKEQGYIF GDYIERLWAY LTIEQLLEKR KNARGDEKEN ITAEALELSL KYHFVTPLTS
610 620 630 640 650 660
MVVTKPEDNE DQTAIADKPG EEAISASTAY LTSQQSSHSP YYYVDGDPHF IIQVPGKNDT
670 680 690 700 710 720
ICFNIDEKPG TVLSLIQDPV TGIAVTGQII GEKGNNASSR TGKTYFGKLG IANAWMDFRI
730 740 750 760 770 780
EVTTEKIILG NGDALSTFSW LDTVTVTQTG LSVTINRKKN MVVSFEDGIS FVIVLHQVWK
790 800 810 820 830 840
KHPVHQDFLG FYVVDSHRMS AQTHGLLGQF FQPFDFKVFD VRPGSDPMKP DATMVVKSHR
850 860 870 880
LTVTRGSQKD YRKDASVGTK VVCWFVHNNG EGFIDGVHTD YIVPSLF