P79263

PR
Gene name
ITIH4 (IHRP)
Protein name
Inter-alpha-trypsin inhibitor heavy chain H4
Names
ITI heavy chain H4, ITI-HC4, Inter-alpha-inhibitor heavy chain 4, Inter-alpha-trypsin inhibitor family heavy chain-related protein, IHRP, Major acute phase protein, MAP
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:396799
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

73-142 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P79263

Entry ID Method Resolution Chain Position Source
AF-P79263-F1 Predicted AlphaFoldDB

No variants for P79263

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P79263

No associated diseases with P79263

3 regional properties for P79263

Type Name Position InterPro Accession
domain von Willebrand factor, type A 270 - 453 IPR002035
domain Inter-alpha-trypsin inhibitor heavy chain, C-terminal 764 - 919 IPR010600
domain VIT domain 18 - 146 IPR013694

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

1 GO annotations of molecular function

Name Definition
serine-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

3 GO annotations of biological process

Name Definition
acute-phase response An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.
hyaluronan metabolic process The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
response to cytokine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3T052 ITIH4 Inter-alpha-trypsin inhibitor heavy chain H4 Bos taurus (Bovine) PR
Q86UX2 ITIH5 Inter-alpha-trypsin inhibitor heavy chain H5 Homo sapiens (Human) PR
Q06033 ITIH3 Inter-alpha-trypsin inhibitor heavy chain H3 Homo sapiens (Human) PR
Q63416 Itih3 Inter-alpha-trypsin inhibitor heavy chain H3 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MKTLSPTGYG LLLVLPLLLA VLQSTTAHKN DINIYSLTVD SKVSSRFAHT VVTSRVVNKG
70 80 90 100 110 120
SAVQEATFQM ELPKKAFITN FSMIIDGVTY PGNIKEKAAA QEQYSAVARG ESAGLVRATG
130 140 150 160 170 180
RKTEQFQVAV SVAPAAKVTF ELVYEELLAR HLGVYELLLK IQPQQLVKHL QMDIHIFEPQ
190 200 210 220 230 240
GISFLETEST FMTNELAEAL TISQNKTKAH IRFKPTLSQQ QKSPEQQETV LDGNFIVRYD
250 260 270 280 290 300
VNRTVTGGSI QIENGYFVHY FAPEVWSAIP KNVIFVIDTS GSMRGRKIQQ TREALIKILG
310 320 330 340 350 360
DLGSRDQFNL VSFSGEAPRR RAVAASAENV EEAKSYAAEI HAQGGTNIND AMLMAVQLLE
370 380 390 400 410 420
RANREELLPA RSVTFIILLT DGDPTVGETN PSKIQKNVRE AIDGQHSLFC LGFGFDVPYA
430 440 450 460 470 480
FLEKMALENG GLARRIYEDS DSALQLEDFY QEVANPLLRL VAFEYPSNAV EEVTQDNFRL
490 500 510 520 530 540
FFKGSELVVA GKLRDQSPDV LSAKVRGQLH MENVTFVMES RVAEQEAEFL SPKYIFHSFM
550 560 570 580 590 600
ERLWAYLTIQ QLLAQTVSAS DAEKKALEAR ALSLSLNYSF VTPLTSMVIT KPEGQEQSQV
610 620 630 640 650 660
AEKPVENGNR QGNTHSGHSS FQFHSVGDRT SRLTGGSSVD PVFSHRRGWK GQAQGFEKMS
670 680 690 700 710 720
YLPPRLGPPG PLQPTRFSHP FSRITLDRVL PEVLSVPDET SHDMDSRIIG ATIPPPPARI
730 740 750 760 770 780
QAPSVILPLP GQSVDQLCVD LKHSQGPVKL LSDPGQGVEV TGHYEREKAR FSWIEVTFKH
790 800 810 820 830 840
PPLQVRASLE HIVVIRNRQS SAYKWKETLY SVMPGLKITM DKAGLLLLSS PNRVTIGLLS
850 860 870 880 890 900
WDGPGKGLRL LLRDTDHFSS QISGTFGQFY QDVVWGPPAA ADDSKRTVTV QGHDHSATRE
910 920
LKLDYQEGSP GKEISCWTVV L