Q850M0

PR
Gene name
TPKA (KCO1)
Protein name
Two pore potassium channel a
Names
Two K(+) channel a, Calcium-activated outward-rectifying potassium channel 1, OsKCO1
Species
Oryza sativa subsp japonica (Rice)
KEGG Pathway
osa:4334137
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-80 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q850M0

Entry ID Method Resolution Chain Position Source
AF-Q850M0-F1 Predicted AlphaFoldDB

No variants for Q850M0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q850M0

No associated diseases with Q850M0

4 regional properties for Q850M0

Type Name Position InterPro Accession
domain EF-hand domain 315 - 347 IPR002048
domain Potassium channel domain 74 - 150 IPR013099-1
domain Potassium channel domain 191 - 263 IPR013099-2
binding_site EF-Hand 1, calcium-binding site 328 - 340 IPR018247

Functions

Description
EC Number
Subcellular Localization
  • Vacuole membrane ; Multi-pass membrane protein
  • Tonoplast of large vacuoles
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plant-type vacuole membrane The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana.
potassium ion-transporting ATPase complex Protein complex that carries out the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). It is a high affinity potassium uptake system. The E. coli complex consists of 4 proteins: KdpA is the potassium ion translocase, KdpB is the ATPase, and KdpC and KdpF seem to be involved in assembly and stabilization of the complex.

4 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
inward rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.
outward rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force.
potassium ion leak channel activity Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state.

3 GO annotations of biological process

Name Definition
cellular potassium ion homeostasis Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell.
potassium ion transmembrane transport A process in which a potassium ion is transported from one side of a membrane to the other.
stabilization of membrane potential The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q7Z418 KCNK18 Potassium channel subfamily K member 18 Homo sapiens (Human) PR
Q96T55 KCNK16 Potassium channel subfamily K member 16 Homo sapiens (Human) PR
O08581 Kcnk1 Potassium channel subfamily K member 1 Mus musculus (Mouse) PR
Q6VV64 Kcnk18 Potassium channel subfamily K member 18 Mus musculus (Mouse) PR
Q22271 unc-58 Uncoordinated protein 58 Caenorhabditis elegans PR
10 20 30 40 50 60
MDDNSIQQSL LADNPNVLQR KPSEGVNRFR RCRSTPSTDP LQGPPEKGSS VKAKELFKEM
70 80 90 100 110 120
RPSFRLVGLL LFIYLLVGVL AFYAVMDEIS GKRTNRVLDA LYFCVVTMTT VGYGDLVPNN
130 140 150 160 170 180
DTTKLLACAF VFMGMAVVAL FVSKVADYLV EKQEVLFFKA LHTNLKGGET KMLRAIETNR
190 200 210 220 230 240
IKYKFYTNAL LLVLSIISGT VFLWKVEKLS LVDSFYCVCA TITTLGYGDK SFSSKLGRVF
250 260 270 280 290 300
AVFWIITSTI IMAQFFMYLA EIYTERRQKM LANWVLTRKM TKMDLEAADL DDDRQVGAAE
310 320 330 340
FVVYKLKELG KINQEEISSF LEEFEKLDVD HSGTLSPYDL TLAQSAQ