Q6VV64
Gene name |
Kcnk18 (Tresk-2, Tresk2) |
Protein name |
Potassium channel subfamily K member 18 |
Names |
Two-pore-domain potassium channel TRESK |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:332396 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6VV64
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6VV64-F1 | Predicted | AlphaFoldDB |
9 variants for Q6VV64
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs222607884 | 69 | L>F | No | EVA | |
| rs3389549154 | 159 | L>I | No | EVA | |
| rs235001342 | 228 | K>R | No | EVA | |
| rs241172871 | 251 | K>E | No | EVA | |
| rs3389549600 | 267 | E>* | No | EVA | |
| rs3389456327 | 277 | I>S | No | EVA | |
| rs264821882 | 302 | V>I | No | EVA | |
| rs3389564454 | 342 | V>M | No | EVA | |
| rs3389549605 | 350 | L>R | No | EVA |
No associated diseases with Q6VV64
2 regional properties for Q6VV64
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Potassium channel domain | 110 - 166 | IPR013099-1 |
| domain | Potassium channel domain | 302 - 374 | IPR013099-2 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium-activated potassium channel activity | Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient. |
| outward rectifier potassium channel activity | Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force. |
| potassium ion leak channel activity | Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to pH | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. |
| potassium ion export across plasma membrane | The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region. |
| potassium ion transmembrane transport | A process in which a potassium ion is transported from one side of a membrane to the other. |
| potassium ion transport | The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| stabilization of membrane potential | The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96T55 | KCNK16 | Potassium channel subfamily K member 16 | Homo sapiens (Human) | PR |
| Q7Z418 | KCNK18 | Potassium channel subfamily K member 18 | Homo sapiens (Human) | PR |
| O08581 | Kcnk1 | Potassium channel subfamily K member 1 | Mus musculus (Mouse) | PR |
| Q850M0 | TPKA | Two pore potassium channel a | Oryza sativa subsp japonica (Rice) | PR |
| Q22271 | unc-58 | Uncoordinated protein 58 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEAEEPPEAR | RCCPEALGKA | RGCCPEALGK | LLPGLCFLCC | LVTYALVGAA | LFSAVEGRPD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PEAEENPELK | KFLDDLCNIL | KCNLTVVEGS | RKNLCEHLQH | LKPQWLKAPQ | DWSFLSALFF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CCTVFSTVGY | GHMYPVTRLG | KFLCMLYALF | GIPLMFLVLT | DIGDILATIL | SRAYSRFQAL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LCLPHDIFKW | RSLPLCRKQP | DSKPVEEAIP | QIVIDAGVDE | LLNPQPSKDP | PSPSCNVELF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ERLVAREKKN | KLQPPTRPVE | RSNSCPELVL | GRLSCSILSN | LDEVGQQVER | LDIPLPVIAL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VVFAYISCAA | AILPFWETEL | GFEDAFYFCF | VTLTTIGFGD | IVLVHPHFFL | FFSIYIIVGM |
| 370 | 380 | 390 | |||
| EILFIAFKLM | QNRLLHTYKT | LMLFVCQREV | SLPW |