Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q22271
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q22271-F1 | Predicted | AlphaFoldDB |
No variants for Q22271
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q22271 | |||||
No associated diseases with Q22271
2 regional properties for Q22271
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Potassium channel domain | 285 - 343 | IPR013099-1 |
| domain | Potassium channel domain | 407 - 475 | IPR013099-2 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| outward rectifier potassium channel activity | Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force. |
| potassium ion leak channel activity | Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| locomotion | Self-propelled movement of a cell or organism from one location to another. |
| muscle contraction | A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. |
| parturition | The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs. |
| potassium ion transmembrane transport | A process in which a potassium ion is transported from one side of a membrane to the other. |
| regulation of muscle contraction | Any process that modulates the frequency, rate or extent of muscle contraction. |
| stabilization of membrane potential | The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96T55 | KCNK16 | Potassium channel subfamily K member 16 | Homo sapiens (Human) | PR |
| Q7Z418 | KCNK18 | Potassium channel subfamily K member 18 | Homo sapiens (Human) | PR |
| O08581 | Kcnk1 | Potassium channel subfamily K member 1 | Mus musculus (Mouse) | PR |
| Q6VV64 | Kcnk18 | Potassium channel subfamily K member 18 | Mus musculus (Mouse) | PR |
| Q850M0 | TPKA | Two pore potassium channel a | Oryza sativa subsp japonica (Rice) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFFYSPNVAP | QPSSTSHRRP | TLTHQHHLHV | GHLDTRLSVQ | IPEILSRSLV | HDPERTRLVP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EQLRFIIDEN | QELWTGSQPP | TGFLELCASP | VSSVFSNADA | RRMSQRKLVL | RRPTISIQED |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GKIIIDHVTA | RWEGANINSQ | SALLDADDGA | TVITDTIKDD | QDDKEPKSCP | QQTVKYIKIL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TPHVILVSVL | IGYLCLGAWI | LMLLETRTEL | LARSKKLVRL | TNLMSNFTAE | SWKMLNNAQH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GVSNMDEGEW | AATFREWMVR | VSETVDDRRP | IRRELNRPDD | LSNMHNKWTF | PTAILYVLTV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LTTCGYGEVS | VDTDVGKVFS | VAFALVGIPL | MFITAADIGK | FLSETLLQFV | SFWNRSVRKV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KQWMSRIRHG | RRKSLQSTGG | PNDTLDILGV | DGTEEKLWFP | IGAYVSCICI | YCSIGSAMFI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TWERTWSFIH | AFHFGFNLIV | TVGLGDIVVT | DYIFLSLIVA | FVIVGLSVVT | MCVDLASTHL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KAYFTRIHYF | GRAKRFLGMS | EELKEIVALL | GAMRRKKGGK | VTWNDVRDFL | DNELRDRPFE |
| 550 | 560 | 570 | 580 | 590 | |
| PHELLMKLRF | IDETSSGMST | IRHNSFQSDF | FRESEYIRRV | AALRPEQPAY | L |