AiPD: Autoinhibited Protein Database

Gene name	Trit1 (Ipt)
Protein name	tRNA dimethylallyltransferase
Names	Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, tRNA isopentenyltransferase, IPTase
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:66966
EC number	2.5.1.75: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-49 (Predicted disordered autoinhibitory region) PR

1-49 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q80UN9-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388703503	24	P>S	No	EVA
rs3388703831	40	A>T	No	EVA
rs264500371	70	V>A	No	EVA
rs48203873	122	T>P	No	EVA
rs221604149	137	T>P	No	EVA
rs3388694851	150	R>L	No	EVA
rs3388703878	158	D>G	No	EVA
rs3388706415	173	M>I	No	EVA
rs3388714040	173	M>T	No	EVA
rs3388706424	181	D>H	No	EVA
rs3388703860	205	R>C	No	EVA
rs3388713966	262	R>G	No	EVA
rs3388708401	292	L>R	No	EVA
rs3388701999	329	V>I	No	EVA
rs3388687536	333	F>I	No	EVA
rs13468654	379	M>T	No	EVA
rs13468653	384	A>T	No	EVA
rs3388709159	397	C>Y	No	EVA
rs243402675	451	I>S	No	EVA
rs3388711053	455	S>A	No	EVA
rs3388709202	463	L>M	No	EVA
rs3388694831	463	L>P	No	EVA

Type	Name	Position	InterPro Accession
domain	Zinc finger, double-stranded RNA binding	395 - 419	IPR022755

		Description
EC Number	2.5.1.75	Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization	[Isoform 1]: Mitochondrion ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding	Binding to a metal ion.
tRNA dimethylallyltransferase activity	Catalysis of the reaction: dimethylallyl diphosphate + tRNA = diphosphate + tRNA containing 6-dimethylallyladenosine.

Name	Definition
mitochondrial tRNA modification	The covalent alteration of one or more nucleotides within a mitochondrial tRNA molecule to produce a mitochondrial tRNA molecule with a sequence that differs from that coded genetically.
tRNA modification	The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P16384	miaA	tRNA dimethylallyltransferase	Escherichia coli (strain K12)	PR
Q9H3H1	TRIT1	tRNA dimethylallyltransferase	Homo sapiens (Human)	PR
Q9LJL4	IPT8	Adenylate isopentenyltransferase 8, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR
Q93WC9	IPT3	Adenylate isopentenyltransferase 3, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR