P16384

PR
Gene name
miaA (trpX, b4171, JW4129)
Protein name
tRNA dimethylallyltransferase
Names
Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b4171
EC number
2.5.1.75: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

95-188 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for P16384

Entry ID Method Resolution Chain Position Source
2ZM5 X-ray 255 A A/B 1-316 PDB
2ZXU X-ray 275 A A/B 1-316 PDB
3FOZ X-ray 250 A A/B 1-316 PDB
AF-P16384-F1 Predicted AlphaFoldDB

No variants for P16384

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P16384

No associated diseases with P16384

No regional properties for P16384

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P16384

Functions

Description
EC Number 2.5.1.75 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA dimethylallyltransferase activity Catalysis of the reaction: dimethylallyl diphosphate + tRNA = diphosphate + tRNA containing 6-dimethylallyladenosine.

3 GO annotations of biological process

Name Definition
cellular response to heat Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
regulation of cytoplasmic translation in response to stress Modulation of the frequency, rate or extent of cytoplasmic translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9H3H1 TRIT1 tRNA dimethylallyltransferase Homo sapiens (Human) PR
Q80UN9 Trit1 tRNA dimethylallyltransferase Mus musculus (Mouse) PR
Q9LJL4 IPT8 Adenylate isopentenyltransferase 8, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q93WC9 IPT3 Adenylate isopentenyltransferase 3, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSDISKASLP KAIFLMGPTA SGKTALAIEL RKILPVELIS VDSALIYKGM DIGTAKPNAE
70 80 90 100 110 120
ELLAAPHRLL DIRDPSQAYS AADFRRDALA EMADITAAGR IPLLVGGTML YFKALLEGLS
130 140 150 160 170 180
PLPSADPEVR ARIEQQAAEQ GWESLHRQLQ EVDPVAAARI HPNDPQRLSR ALEVFFISGK
190 200 210 220 230 240
TLTELTQTSG DALPYQVHQF AIAPASRELL HQRIEQRFHQ MLASGFEAEV RALFARGDLH
250 260 270 280 290 300
TDLPSIRCVG YRQMWSYLEG EISYDEMVYR GVCATRQLAK RQITWLRGWE GVHWLDSEKP
310
EQARDEVLQV VGAIAG