Q80TI0

PR
Gene name
Gramd1b (Kiaa1201)
Protein name
Protein Aster-B
Names
GRAM domain-containing protein 1B
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:235283
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-100 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q80TI0

Entry ID Method Resolution Chain Position Source
AF-Q80TI0-F1 Predicted AlphaFoldDB

No variants for Q80TI0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q80TI0

No associated diseases with Q80TI0

3 regional properties for Q80TI0

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 134 - 145 IPR001412
domain DALR anticodon binding 463 - 578 IPR008909
domain Arginyl-tRNA synthetase, catalytic core domain 124 - 449 IPR035684

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass membrane protein
  • Cell membrane ; Single-pass membrane protein
  • In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
endoplasmic reticulum-plasma membrane contact site A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

6 GO annotations of molecular function

Name Definition
cholesterol binding Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
cholesterol transfer activity Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
phosphatidic acid binding Binding to phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
phosphatidylserine binding Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
sterol binding Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol.
sterol transfer activity Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.

3 GO annotations of biological process

Name Definition
cellular response to cholesterol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus.
cholesterol homeostasis Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
intracellular sterol transport The directed movement of sterols within cells.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8IYS0 GRAMD1C Protein Aster-C Homo sapiens (Human) PR
Q96CP6 GRAMD1A Protein Aster-A Homo sapiens (Human) PR
Q3KR37 GRAMD1B Protein Aster-B Homo sapiens (Human) PR
Q9ZVT9 At1g03370 C2 and GRAM domain-containing protein At1g03370 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FGS8 At5g50170 C2 and GRAM domain-containing protein At5g50170 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MKGFKLSCTA SNSNRSTPAC SPILRKRSRS PTPQNQDGDT MVEKGSDHSS DKSPSTPEQG
70 80 90 100 110 120
VQRSCSSQSG RSGGKNSKKS QSWYNVLSPT YKQRNEDFRK LFKQLPDTER LIVDYSCALQ
130 140 150 160 170 180
RDILLQGRLY LSENWICFYS NIFRWETLLT VRLKDICSMT KEKTARLIPN AIQVCTDSEK
190 200 210 220 230 240
HFFTSFGARD RTYMMMFRLW QNALLEKPLC PKELWHFVHQ CYGNELGLTS DDEDYVPPDD
250 260 270 280 290 300
DFNTMGYCEE IPIEENEVND SSSKSSIETK PDASPQLPKK SITNSTLTST GSSEAPVSFD
310 320 330 340 350 360
GLPLEEEVME GDGSLEKELA IDNIIGEKIE IMAPVTSPSL DFNDNEDIPT ELSDSSDTHD
370 380 390 400 410 420
EGEVQAFYED LSGRQYVNEV FNFSVDKLYD LLFTNSPFLR DFMEQRRFSD IIFHPWKKEE
430 440 450 460 470 480
NGNQSRVILY TITLTNPLAP KTATVRETQT MYKASQESEC YVIDAEVLTH DVPYHDYFYT
490 500 510 520 530 540
INRYTLTRVA RNKSRLRVST ELRYRKQPWG FVKTFIEKNF WSGLEDYFRH LETELTKTES
550 560 570 580 590 600
TYLAEIHRQS PKEKASKSSA VRRRKRPHAH LRVPHLEEVM SPVTTPTDED VGHRIKHVAG
610 620 630 640 650 660
STQTRHIPED TPDGFHLQSV SKLLLVISCV ICFSLVLLVV LNMMLFYKLW MLEYTTQTLT
670 680 690 700 710 720
AWQGLRLQER LPQSQTEWAQ LLESQQKYHD TELQKWREII KSSVLLLDQM KDSLINLQNG
730
IRSRDYTAES DEKRNRYH