AiPD: Autoinhibited Protein Database

Q7Z7C8

Gene name	TAF8 (TAFII43, TBN)
Protein name	Transcription initiation factor TFIID subunit 8
Names	Protein taube nuss, TBP-associated factor 43 kDa, TBP-associated factor 8, Transcription initiation factor TFIID 43 kDa subunit, TAFII-43, TAFII43, hTAFII43
Species	Homo sapiens (Human)
KEGG Pathway	hsa:129685
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-57 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

32 structures for Q7Z7C8

Entry ID	Method	Resolution	Chain	Position	Source
4WV4	X-ray	191 A	B	25-120	PDB
4WV6	X-ray	175 A	B/C	297-310	PDB
5FUR	EM	850 A	L	1-310	PDB
6MZC	EM	450 A	K	1-310	PDB
6MZL	EM	2300 A	K	1-310	PDB
6MZM	EM	750 A	K	1-310	PDB
7EDX	EM	450 A	H	1-310	PDB
7EG7	EM	620 A	H	1-310	PDB
7EG8	EM	740 A	H	1-310	PDB
7EG9	EM	370 A	H	1-310	PDB
7EGA	EM	410 A	H	1-310	PDB
7EGB	EM	330 A	H	1-310	PDB
7EGC	EM	390 A	H	1-310	PDB
7EGD	EM	675 A	H	1-310	PDB
7EGE	EM	900 A	H	1-310	PDB
7EGG	EM	277 A	H	1-310	PDB
7EGH	EM	304 A	H	1-310	PDB
7EGI	EM	982 A	H	1-310	PDB
7EGJ	EM	864 A	H	1-310	PDB
7ENA	EM	407 A	DH	1-310	PDB
7ENC	EM	413 A	DH	1-310	PDB
8GXQ	EM	504 A	DH	1-310	PDB
8GXS	EM	416 A	DH	1-310	PDB
8WAK	EM	547 A	H	1-310	PDB
8WAL	EM	852 A	H	1-310	PDB
8WAN	EM	607 A	H	1-310	PDB
8WAO	EM	640 A	H	1-310	PDB
8WAP	EM	585 A	H	1-310	PDB
8WAQ	EM	629 A	H	1-310	PDB
8WAR	EM	720 A	H	1-310	PDB
8WAS	EM	613 A	H	1-310	PDB
AF-Q7Z7C8-F1	Predicted				AlphaFoldDB

301 variants for Q7Z7C8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA3804493 rs751006594	2	A>V		No	ClinGen ExAC TOPMed gnomAD
CA3804494 rs757004180	3	D>G		No	ClinGen ExAC gnomAD
CA364087416 rs1178107080	3	D>N		No	ClinGen Ensembl
rs573020143 CA138128506	4	A>G		No	ClinGen 1000Genomes TOPMed gnomAD
rs1050521943 CA138128503	4	A>P		No	ClinGen TOPMed gnomAD
rs1050521943 CA364087481	4	A>T		No	ClinGen TOPMed gnomAD
CA364087494 rs573020143	4	A>V		No	ClinGen 1000Genomes TOPMed gnomAD
CA138128507 rs555280249	5	A>T		No	ClinGen 1000Genomes TOPMed
CA364087532 rs1286689998	5	A>V		No	ClinGen TOPMed gnomAD
CA364087537 rs1287003435	6	A>T		No	ClinGen TOPMed
rs1435531116 CA364087550	6	A>V		No	ClinGen gnomAD
rs768929303 CA3804497	7	T>A		No	ClinGen ExAC TOPMed gnomAD
CA138128514 rs1005039057	7	T>I		No	ClinGen TOPMed gnomAD
rs748678333 CA3804499	8	A>G		No	ClinGen ExAC TOPMed gnomAD
CA3804498 rs779286517	8	A>S		No	ClinGen ExAC TOPMed gnomAD
rs779286517 CA364087620	8	A>T		No	ClinGen ExAC TOPMed gnomAD
CA364087681 rs773491807	10	A>S		No	ClinGen ExAC TOPMed
CA3804501 rs773491807	10	A>T		No	ClinGen ExAC TOPMed
rs183028083 CA3804502	10	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA138128534 rs1015767224	11	G>C		No	ClinGen TOPMed gnomAD
rs1015767224 CA364087696	11	G>S		No	ClinGen TOPMed gnomAD
rs868161378 CA364087762	13	S>F		No	ClinGen TOPMed gnomAD
rs759765030 CA3804505	13	S>P		No	ClinGen ExAC TOPMed gnomAD
CA138128555 rs868161378	13	S>Y		No	ClinGen TOPMed gnomAD
CA364087786 rs1160970521	14	G>E		No	ClinGen gnomAD
CA364087765 rs1457483099 CA364087769	14	G>R		No	ClinGen gnomAD
CA3804507 rs752435360	15	T>M		No	ClinGen ExAC TOPMed gnomAD
CA364087815 rs752435360	15	T>R		No	ClinGen ExAC TOPMed gnomAD
rs755786579 CA3804536	17	S>L		No	ClinGen ExAC gnomAD
CA3804538 rs531214257	18	G>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3804539 rs758806468	18	G>A		No	ClinGen ExAC gnomAD
rs531214257 CA364089438	18	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1028796330 CA138129020	19	S>R		No	ClinGen Ensembl
CA3804541 rs373530647	21	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA3804540 rs551322668	21	Q>P		No	ClinGen 1000Genomes ExAC gnomAD
rs1226732787 CA364089544	22	S>C		No	ClinGen gnomAD
rs1226732787 CA364089545	22	S>F		No	ClinGen gnomAD
CA3804542 rs757728659	22	S>P		No	ClinGen ExAC
CA3804544 rs745958022	23	T>I		No	ClinGen ExAC
rs781140275 CA3804543	23	T>P		No	ClinGen ExAC
CA3804547 rs74710424	24	N>T		No	ClinGen ExAC gnomAD
CA3804548 rs768457784	25	P>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	25	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA364089678 rs1229927241	26	A>T		No	ClinGen gnomAD
rs1310581657 CA364089704	27	D>N		No	ClinGen TOPMed
CA364089715 rs1441355382	28	N>D		No	ClinGen gnomAD
TCGA novel	29	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs956006606 CA138129062	29	Y>C		No	ClinGen TOPMed gnomAD
CA364089771 rs1463375464	30	H>Y		No	ClinGen TOPMed gnomAD
rs915130570 CA138129068	31	L>R		No	ClinGen TOPMed gnomAD
CA364089843 rs767483326	33	R>L		No	ClinGen ExAC gnomAD
CA3804553 rs767483326	33	R>Q		No	ClinGen ExAC gnomAD
rs772654780 CA3804554	34	R>K		No	ClinGen ExAC gnomAD
TCGA novel	37	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1413992813 CA364089927	37	L>Q		No	ClinGen gnomAD
CA3804555 rs760208849	38	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA3804557 rs753576013	39	V>G		No	ClinGen ExAC TOPMed gnomAD
CA3804559 rs764568765	40	V>G		No	ClinGen ExAC gnomAD
rs1452480418 CA364090061	41	V>E		No	ClinGen Ensembl
rs376399735 CA3804561	41	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1273593268 CA364090093	43	S>P		No	ClinGen gnomAD
CA3804562 rs781717709	44	L>V		No	ClinGen ExAC gnomAD
rs1554170019 CA3804564	47	E>V		No	ClinGen Ensembl
rs1562007337 CA364090265	48	A>V		No	ClinGen Ensembl
CA364090304 rs1326700344	49	G>A		No	ClinGen gnomAD
rs756213236 CA3804567	49	G>R		No	ClinGen ExAC gnomAD
CA364090310 rs1582208388	50	F>V		No	ClinGen Ensembl
rs780055411 CA3804568	52	S>I		No	ClinGen ExAC gnomAD
CA364090385 rs1582208405	52	S>R		No	ClinGen Ensembl
CA3804570 rs749522287	53	A>G		No	ClinGen ExAC TOPMed gnomAD
CA364090418 rs1248371235	53	A>S		No	ClinGen gnomAD
CA3804569 rs749522287	53	A>V		No	ClinGen ExAC TOPMed gnomAD
CA138129184 rs942821006	54	E>K		No	ClinGen gnomAD
CA364090453 rs942821006	54	E>Q		No	ClinGen gnomAD
rs1431674783 CA364090511	56	A>V		No	ClinGen gnomAD
CA3804573 rs747961595	57	S>F		No	ClinGen ExAC TOPMed gnomAD
rs771952250 CA3804574	59	E>A		No	ClinGen ExAC TOPMed gnomAD
rs771952250 CA138129205	59	E>V		No	ClinGen ExAC TOPMed gnomAD
rs370822634 CA3804575	60	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs999781686 CA138129213	60	T>M		No	ClinGen gnomAD
rs1436547498 CA364090601	61	L>P		No	ClinGen gnomAD
rs770589974 CA3804577	61	L>V		No	ClinGen ExAC gnomAD
rs374257808 CA3804578	63	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	63	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA364090657 rs1348124652	64	M>L		No	ClinGen gnomAD
CA364090659 rs1348124652	64	M>V		No	ClinGen gnomAD
CA364090706 rs764979779	66	Q>*		No	ClinGen ExAC gnomAD
rs764979779 CA3804580	66	Q>E		No	ClinGen ExAC gnomAD
rs1457103305 CA364092429	68	Y>C		No	ClinGen TOPMed
CA3804603 rs750684997	69	I>F		No	ClinGen ExAC gnomAD
CA364092454 rs750684997	69	I>L		No	ClinGen ExAC gnomAD
rs761234284 CA3804604	71	E>D		No	ClinGen ExAC gnomAD
rs919633649 CA138131129	71	E>K		No	ClinGen TOPMed
CA364092602 rs1160984516	72	I>M		No	ClinGen TOPMed
CA364092609 CA364092604 rs1473339290	73	G>R		No	ClinGen gnomAD
rs1376582656 CA364092634	74	R>G		No	ClinGen TOPMed
rs749824663 CA138131137	75	S>N		No	ClinGen gnomAD
CA3804605 rs766856727	76	A>G		No	ClinGen ExAC gnomAD
rs1041925804 CA138131142	76	A>T		No	ClinGen Ensembl
CA364092719 rs766856727	76	A>V		No	ClinGen ExAC gnomAD
rs755019294 CA364092740	77	K>E		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	77	K>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3804607 rs755019294	77	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA138131164 rs1050049842	77	K>R		No	ClinGen TOPMed gnomAD
CA3804610 rs758493295	80	C>G		No	ClinGen ExAC gnomAD
CA364092814 rs758493295	80	C>R		No	ClinGen ExAC gnomAD
rs1341430106 CA364092877	82	H>Y		No	ClinGen gnomAD
rs1246371188 CA364092932	83	T>I		No	ClinGen TOPMed
rs777630505 CA3804611	84	A>T		No	ClinGen ExAC gnomAD
CA138131178 rs928658205	85	R>G		No	ClinGen TOPMed
rs1341590714 CA364092985	85	R>S		No	ClinGen gnomAD
CA364092964 rs928658205	85	R>W		No	ClinGen TOPMed
rs1198889856 CA364093004	86	T>I		No	ClinGen TOPMed gnomAD
rs757324476 CA3804613	87	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA3804615 rs745415464	90	L>R		No	ClinGen ExAC TOPMed gnomAD
CA364093096 rs1185876672	90	L>V		No	ClinGen gnomAD
CA364093149 rs1374232301	92	D>A		No	ClinGen gnomAD
rs368588507 CA3804617	92	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA3804619 rs547928279	94	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA364093263 rs1318340299	97	L>P		No	ClinGen gnomAD
CA364093261 rs1318340299	97	L>R		No	ClinGen gnomAD
rs1454357869 CA364093255	97	L>V		No	ClinGen gnomAD
rs536405539 CA3804621	98	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs536405539 CA3804622	98	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA364093285 rs1170298007	99	E>K		No	ClinGen TOPMed
rs1313353543 CA364093339	100	M>I		No	ClinGen gnomAD
rs777153742 CA3804623	100	M>T		No	ClinGen ExAC gnomAD
rs1582216245 CA364093479	101	G>D		No	ClinGen Ensembl
CA364093508 rs1262993724	103	N>K		No	ClinGen TOPMed gnomAD
rs760094311 CA3804641	103	N>S		No	ClinGen ExAC TOPMed gnomAD
CA138131390 rs957816690	104	V>M		No	ClinGen TOPMed
rs765658996 CA3804642	105	D>A		No	ClinGen ExAC TOPMed gnomAD
CA3804643 rs765658996	105	D>G		No	ClinGen ExAC TOPMed gnomAD
CA364093522 rs1441419714	105	D>N		No	ClinGen TOPMed
CA364093555 rs1281658518	107	L>F		No	ClinGen TOPMed gnomAD
CA364093574 rs762921654	108	P>L		No	ClinGen ExAC gnomAD
rs762921654 CA3804646	108	P>R		No	ClinGen ExAC gnomAD
rs758273833 CA364093630	110	Y>*		No	ClinGen TOPMed gnomAD
CA364093602 rs1419442628	110	Y>N		No	ClinGen gnomAD
TCGA novel	111	A>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3804648 rs751865496	111	A>T		No	ClinGen ExAC gnomAD
CA364093697 rs1294055355	113	R>W		No	ClinGen gnomAD
rs750235942 CA3804653	117	M>V		No	ClinGen ExAC gnomAD
rs752200321 CA3804678	122	P>L		No	ClinGen ExAC gnomAD
rs779832016 CA3804655	122	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs201356964 CA138132152	123	P>L		No	ClinGen ExAC TOPMed gnomAD
rs201356964 CA3804679	123	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs201356964 CA364095596	123	P>R		No	ClinGen ExAC TOPMed gnomAD
CA3804681 rs746287434	124	V>G		No	ClinGen ExAC gnomAD
rs777384806 CA3804680	124	V>L		No	ClinGen ExAC gnomAD
rs1447537719 CA364095695	126	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs770090308 CA3804682	128	P>S		No	ClinGen ExAC gnomAD
CA3804683 rs780421286	130	T>N		No	ClinGen ExAC gnomAD
CA364095789 rs1582218473	130	T>P		No	ClinGen Ensembl
CA3804686 rs774628411	132	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1469595508 CA364095954	133	A>V		No	ClinGen gnomAD
rs1582218548 CA364096145	139	N>T		No	ClinGen Ensembl
rs773336996 CA3804689	140	R>*		No	ClinGen ExAC TOPMed gnomAD
rs200166840 CA3804690	140	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1276039095 CA364096219	141	P>L		No	ClinGen TOPMed gnomAD
rs1276039095 CA364096217	141	P>R		No	ClinGen TOPMed gnomAD
CA3804693 rs766100611	142	H>P		No	ClinGen ExAC gnomAD
rs373004161 CA3804694	143	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs374681523 CA3804695	144	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA364096357 rs374681523	144	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA364096390 rs1242701273	145	H>Y		No	ClinGen TOPMed gnomAD
CA364096474 rs1354705952	146	I>N		No	ClinGen TOPMed
CA364096479 rs1354705952	146	I>T		No	ClinGen TOPMed
rs1475776722 CA364096457	146	I>V		No	ClinGen gnomAD
CA3804697 rs752255358	147	P>S		No	ClinGen ExAC TOPMed gnomAD
CA3804698 rs757874607	149	H>R		No	ClinGen ExAC gnomAD
rs200962020 CA3804699	150	F>V		No	ClinGen ExAC TOPMed gnomAD
rs968089454 CA138132253	151	P>A		No	ClinGen TOPMed gnomAD
CA3804700 rs201385171	151	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs968089454 CA138132256	151	P>S		No	ClinGen TOPMed gnomAD
CA364096695 rs1408689099	152	E>G		No	ClinGen gnomAD
CA3804702 rs369886097	155	D>G		No	ClinGen ESP ExAC gnomAD
CA364096917 rs1178701501	159	Y>F		No	ClinGen TOPMed
rs1432262852 CA364096908	159	Y>H		No	ClinGen TOPMed gnomAD
rs746487321	164	T>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA364101153 rs1371060055	164	T>A		No	ClinGen TOPMed
TCGA novel	166	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1030879586 CA138142226	167	E>D		No	ClinGen TOPMed
rs765700807 CA3804740	168	P>L		No	ClinGen ExAC gnomAD
CA364101311 rs1445712107	169	V>A		No	ClinGen TOPMed gnomAD
CA3804744 rs374915188	169	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA3804743 COSM1228454 rs374915188	169	V>M	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1185996759 CA364101341	170	S>L		No	ClinGen gnomAD
rs1165602006 CA364101367	171	D>G		No	ClinGen TOPMed
rs1418630138 CA364101424	173	Q>*		No	ClinGen TOPMed
rs371265065 CA3804750	176	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs371265065 CA3804749	176	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA3804748 rs769940264	176	R>W		No	ClinGen ExAC TOPMed gnomAD
rs376100000 CA3804751	177	E>V		No	ClinGen ESP ExAC gnomAD
CA364101662 rs1295333904	180	A>T		No	ClinGen gnomAD
CA3804753 rs201089461	181	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA138142280 rs766136389	182	Q>*		No	ClinGen gnomAD
rs372388576 CA3804755	183	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs760462541 CA3804756	184	R>C		No	ClinGen ExAC gnomAD
CA138142292 rs968814710 COSM1079299	184	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs368068958 CA3804758	185	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA364101884 rs1185898798	186	V>M		No	ClinGen gnomAD
CA138142300 rs532594187	187	E>K		No	ClinGen Ensembl
CA3804759 rs371516491	188	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA364101959 rs1374321126	188	R>Q		No	ClinGen TOPMed gnomAD
rs371516491 CA364101956	188	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs928204960 CA138142310	189	A>T		No	ClinGen Ensembl
rs752136318 CA3804762	191	T>A		No	ClinGen ExAC
rs1406471536 CA364102089	191	T>S		No	ClinGen gnomAD
rs770137667 CA138142329	192	R>C		No	ClinGen TOPMed
CA3804763 rs374759131	192	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs368068359 CA138142347	194	M>T		No	ClinGen Ensembl
rs781258446 CA3804764	194	M>V		No	ClinGen ExAC gnomAD
rs1474866388 CA364102301	197	T>I		No	ClinGen TOPMed gnomAD
CA3804766 rs756372584	199	E>D		No	ClinGen ExAC TOPMed gnomAD
rs544595066 CA3804765	199	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3804768 rs780235922	202	S>N		No	ClinGen ExAC TOPMed gnomAD
CA364102562 rs1282895022	203	L>F		No	ClinGen gnomAD
CA138142357 rs368936827	203	L>P		No	ClinGen ESP TOPMed gnomAD
rs1435317109 CA364102721	206	D>G		No	ClinGen TOPMed
TCGA novel	206	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA364102795 rs1206275063	208	V>A		No	ClinGen gnomAD
CA3804771 rs778507860	208	V>I		No	ClinGen ExAC gnomAD
CA3804772 rs748131198	209	S>G		No	ClinGen ExAC TOPMed gnomAD
rs886522375 CA138142384	210	T>A		No	ClinGen TOPMed gnomAD
rs1367999240 CA364104177	214	I>V		No	ClinGen TOPMed
rs748725698 CA138143608	216	A>P		No	ClinGen TOPMed gnomAD
rs748725698 CA364104266	216	A>S		No	ClinGen TOPMed gnomAD
CA138143613 rs934472680	217	R>G		No	ClinGen TOPMed
CA364104381 rs1357988637	220	T>A		No	ClinGen gnomAD
rs1291816869 CA364104449	222	P>H		No	ClinGen gnomAD
CA364104477 rs1360975312	223	Y>C		No	ClinGen TOPMed gnomAD
rs1360975312 CA364104480	223	Y>F		No	ClinGen TOPMed gnomAD
rs745545223 CA3804797	225	T>S		No	ClinGen ExAC gnomAD
rs1188943239 CA364104526	226	A>T		No	ClinGen TOPMed
CA138143633 rs749869589	227	L>R		No	ClinGen Ensembl
rs746056203	228	L>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA3804800 rs769313819	229	P>L		No	ClinGen ExAC TOPMed gnomAD
rs769313819 CA364104586	229	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA3804799 rs769313819	229	P>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	230	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3804802 rs767823791	230	S>P		No	ClinGen ExAC gnomAD
CA3804803 rs773742959	231	E>Q		No	ClinGen ExAC gnomAD
rs761105655 CA3804804	232	L>R		No	ClinGen ExAC gnomAD
TCGA novel	233	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766461968 CA3804805	233	E>Q		No	ClinGen ExAC gnomAD
rs1168596606 CA364104681	234	M>I		No	ClinGen gnomAD
CA364104735 rs1262290916	236	Q>E		No	ClinGen TOPMed
rs753850736 CA3804807	237	M>R		No	ClinGen ExAC gnomAD
rs753850736 CA3804806	237	M>T		No	ClinGen ExAC gnomAD
CA3804808 rs765346730	242	S>C		No	ClinGen ExAC gnomAD
rs752586050 CA3804809	243	S>L	Variant assessed as Somatic; 4.677e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA364105046 rs1452461216	246	D>N		No	ClinGen gnomAD
CA138143677 rs983766535	247	E>*		No	ClinGen Ensembl
rs1316365787 CA364105213	251	T>A		No	ClinGen TOPMed gnomAD
rs1384344244 CA364105319	254	L>F		No	ClinGen gnomAD
CA138143679 rs1044000808	255	A>V		No	ClinGen TOPMed gnomAD
rs777669969 CA3804812	257	H>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	257	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777669969 CA3804811	257	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1197007290 COSM334713 CA364105450	259	S>G	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA364105461 rs1383199019	259	S>N		No	ClinGen TOPMed
rs1290965710 CA364105510	260	M>I		No	ClinGen TOPMed
rs747344270 CA3804843	262	D>H		No	ClinGen ExAC gnomAD
CA364110609 rs1438320300	263	S>F		No	ClinGen gnomAD
CA3804844 rs189994370	264	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs760047297 CA364110669	266	E>*		No	ClinGen ExAC gnomAD
CA3804847 rs760047297	266	E>K		No	ClinGen ExAC gnomAD
rs760047297 CA364110667	266	E>Q		No	ClinGen ExAC gnomAD
CA3804849 rs769766503	270	T>A		No	ClinGen ExAC TOPMed gnomAD
rs769766503 CA364110804	270	T>P		No	ClinGen ExAC TOPMed gnomAD
CA364110934 rs1318715318	274	Q>*		No	ClinGen gnomAD
TCGA novel	274	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA364111021 rs1582248429	276	N>T		No	ClinGen Ensembl
rs936629996 CA138147326	277	P>T		No	ClinGen Ensembl
CA3804852 rs200995490	278	S>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1245665601 CA364111078	278	S>Y		No	ClinGen gnomAD
COSM1193755 rs372180909 CA3804853	280	S>L	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs767307596 CA3804855	282	S>G		No	ClinGen ExAC gnomAD
CA3804856 rs376494787	282	S>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs878886811 CA138147337	283	R>Q		No	ClinGen Ensembl
rs1291669682 CA364111159	284	N>D		No	ClinGen TOPMed
rs1243138301 CA364111178	285	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA3804861 rs546610742	289	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3804863 rs778515780	291	D>N		No	ClinGen ExAC gnomAD
rs1402184812 CA364111301	293	P>R		No	ClinGen TOPMed gnomAD
TCGA novel	293	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA364111318 rs1370764402	294	Y>C		No	ClinGen TOPMed
CA138147370 rs966434982	296	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1335967843 CA364111345	296	R>W		No	ClinGen gnomAD
rs781551114 CA3804866	297	P>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	297	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA364111374 rs1324766329	298	V>M		No	ClinGen TOPMed gnomAD
rs1418685539 CA364111446	303	I>S		No	ClinGen TOPMed
CA3804869 rs775777569	304	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA3804870 rs749343718	304	R>H		No	ClinGen ExAC TOPMed gnomAD
CA364111470 rs1263034193	305	R>K		No	ClinGen gnomAD
CA3804871 rs769046111	306	K>R		No	ClinGen ExAC TOPMed gnomAD
CA364111560 rs1356664701	309	L>F		No	ClinGen gnomAD
CA3804892 rs561846227	310	S>P		No	ClinGen 1000Genomes ExAC gnomAD
rs1265730693 CA364111581	311	S>R		No	ClinGen gnomAD

No associated diseases with Q7Z7C8

2 regional properties for Q7Z7C8

Type	Name	Position	InterPro Accession
domain	Bromodomain associated domain	29 - 106	IPR006565
domain	Transcription factor TFIID, subunit 8, C-terminal	144 - 197	IPR019473

Functions

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm	Predominantly nuclear
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
transcription factor TFIID complex	A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.

2 GO annotations of molecular function

Name	Definition
protein heterodimerization activity	Binding to a nonidentical protein to form a heterodimer.
RNA polymerase II general transcription initiation factor activity	A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription.

10 GO annotations of biological process

Name	Definition
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
DNA-templated transcription open complex formation	Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.
inner cell mass cell proliferation	The proliferation of cells in the inner cell mass.
maintenance of protein location in nucleus	Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus.
mRNA transcription by RNA polymerase II	The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.
positive regulation of transcription initiation by RNA polymerase II	Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of fat cell differentiation	Any process that modulates the frequency, rate or extent of adipocyte differentiation.
RNA polymerase II preinitiation complex assembly	The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
transcription initiation at RNA polymerase II promoter	A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II.

5 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A7MAZ4	TAF8	Transcription initiation factor TFIID subunit 8	Bos taurus (Bovine)	PR
Q5ZMS1	TAF8	Transcription initiation factor TFIID subunit 8	Gallus gallus (Chicken)	PR
Q9EQH4	Taf8	Transcription initiation factor TFIID subunit 8	Mus musculus (Mouse)	PR
Q28J24	taf8	Transcription initiation factor TFIID subunit 8	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q6P0T2	taf8	Transcription initiation factor TFIID subunit 8	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MADAAATAGA	GGSGTRSGSK	QSTNPADNYH	LARRRTLQVV	VSSLLTEAGF	ESAEKASVET
70	80	90	100	110	120
LTEMLQSYIS	EIGRSAKSYC	EHTARTQPTL	SDIVVTLVEM	GFNVDTLPAY	AKRSQRMVIT
130	140	150	160	170	180
APPVTNQPVT	PKALTAGQNR	PHPPHIPSHF	PEFPDPHTYI	KTPTYREPVS	DYQVLREKAA
190	200	210	220	230	240
SQRRDVERAL	TRFMAKTGET	QSLFKDDVST	FPLIAARPFT	IPYLTALLPS	ELEMQQMEET
250	260	270	280	290	300
DSSEQDEQTD	TENLALHISM	EDSGAEKENT	SVLQQNPSLS	GSRNGEENII	DNPYLRPVKK

PKIRRKKSLS