Q6P0T2

PR
Gene name
taf8 (tbnl)
Protein name
Transcription initiation factor TFIID subunit 8
Names
Protein taube nuss-like, TBP-associated factor 8
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:393256
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-65 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6P0T2

Entry ID Method Resolution Chain Position Source
AF-Q6P0T2-F1 Predicted AlphaFoldDB

No variants for Q6P0T2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6P0T2

No associated diseases with Q6P0T2

2 regional properties for Q6P0T2

Type Name Position InterPro Accession
active_site Transaldolase, active site 31 - 39 IPR018225-1
active_site Transaldolase, active site 132 - 149 IPR018225-2

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
transcription factor TFIID complex A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.

1 GO annotations of molecular function

Name Definition
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.

2 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
transcription initiation at RNA polymerase II promoter A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A7MAZ4 TAF8 Transcription initiation factor TFIID subunit 8 Bos taurus (Bovine) PR
Q5ZMS1 TAF8 Transcription initiation factor TFIID subunit 8 Gallus gallus (Chicken) PR
Q7Z7C8 TAF8 Transcription initiation factor TFIID subunit 8 Homo sapiens (Human) PR
Q9EQH4 Taf8 Transcription initiation factor TFIID subunit 8 Mus musculus (Mouse) PR
Q28J24 taf8 Transcription initiation factor TFIID subunit 8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MADSVMMGSG SLNSGSRSGS SKTCTSPTEN YQLARRRTLQ VVVSALLTEC GFDSAEKAVV
70 80 90 100 110 120
ETLTEMMQSY ITEVGRCAKA NCEHTARSTP TLSDVVITLV EMGFNVDTLP VYAKRSQRMV
130 140 150 160 170 180
ITAPPITNAP VVPKSLTAGQ KRTHPAHIPS HFPDFPDPHT YIRTPTFREP VSDYQVVREK
190 200 210 220 230 240
AASQRRDVER ALTRFMAKTG ETQSLFKDDI SAFPLIAAKP SPIPYLSALL PSELELQSLE
250 260 270 280 290 300
ETDSSEQDDQ MDNDNNTSHI MQDDSGADKE NEVLPPGGVV PSGKANEENM IDNPYLRPVK
KPKVRRKK