Q28J24
Gene name |
taf8 (TNeu125i04.1) |
Protein name |
Transcription initiation factor TFIID subunit 8 |
Names |
TBP-associated factor 8 |
Species |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
KEGG Pathway |
xtr:549471 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q28J24
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q28J24-F1 | Predicted | AlphaFoldDB |
No variants for Q28J24
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q28J24 | |||||
No associated diseases with Q28J24
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| transcription factor TFIID complex | A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| transcription initiation at RNA polymerase II promoter | A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A7MAZ4 | TAF8 | Transcription initiation factor TFIID subunit 8 | Bos taurus (Bovine) | PR |
| Q5ZMS1 | TAF8 | Transcription initiation factor TFIID subunit 8 | Gallus gallus (Chicken) | PR |
| Q7Z7C8 | TAF8 | Transcription initiation factor TFIID subunit 8 | Homo sapiens (Human) | PR |
| Q9EQH4 | Taf8 | Transcription initiation factor TFIID subunit 8 | Mus musculus (Mouse) | PR |
| Q6P0T2 | taf8 | Transcription initiation factor TFIID subunit 8 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFPTIRSCAR | GTSTPADNYM | LARRRTLQVV | VSSLLTEAGF | ESAEKAAVES | LTEMLQSYLS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EIGRSAKSYC | EHTARTQPTL | PDIVVTLIEM | GFNVESLPAY | AKRSQRMVIT | APPVTNNPVV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PKALSAGQNK | QHPAHIPSHF | PEFPDPHTYI | KTPTYREPVC | DYQVLREKAA | SQRRDVERAL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TRFMAKTGET | QSLFKDDTST | FPLIAARPLS | IPYLNALLPS | ELELQQVEET | DSSEQDDQTD |
| 250 | 260 | 270 | 280 | 290 | |
| AENLSMHLQG | DEVGMEKENS | SVLQQNSMKG | GEETLIDNPY | LRPVKKPKLR | RKK |