Q7YQL6
PR
Gene name |
OPHN1 |
Protein name |
Oligophrenin-1 |
Names |
|
Species |
Pan troglodytes (Chimpanzee) |
KEGG Pathway |
ptr:449628 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7YQL6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7YQL6-F1 | Predicted | AlphaFoldDB |
No variants for Q7YQL6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q7YQL6 | |||||
No associated diseases with Q7YQL6
5 regional properties for Q7YQL6
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| dendritic spine | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
| terminal bouton | Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| cell junction assembly | A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction. |
| establishment of epithelial cell apical/basal polarity | The specification and formation of the apicobasal polarity of an epithelial cell. |
| negative regulation of proteasomal protein catabolic process | Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| regulation of endocytosis | Any process that modulates the frequency, rate or extent of endocytosis. |
| regulation of synaptic transmission, glutamatergic | Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| synaptic vesicle endocytosis | A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5ZMW5 | ARHGAP26 | Rho GTPase-activating protein 26 | Gallus gallus (Chicken) | PR |
| Q9UNA1 | ARHGAP26 | Rho GTPase-activating protein 26 | Homo sapiens (Human) | PR |
| A6NI28 | ARHGAP42 | Rho GTPase-activating protein 42 | Homo sapiens (Human) | PR |
| O60890 | OPHN1 | Oligophrenin-1 | Homo sapiens (Human) | PR |
| B2RQE8 | Arhgap42 | Rho GTPase-activating protein 42 | Mus musculus (Mouse) | PR |
| Q6ZQ82 | Arhgap26 | Rho GTPase-activating protein 26 | Mus musculus (Mouse) | PR |
| Q99J31 | Ophn1 | Oligophrenin-1 | Mus musculus (Mouse) | PR |
| P0CAX5 | Ophn1 | Oligophrenin-1 | Rattus norvegicus (Rat) | PR |
| B5DFQ4 | arhgap26 | Rho GTPase-activating protein 26 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGHPPLEFSD | CYLDSPDFRE | RLKCYEQELE | RTNKFIKDVI | KDGNALISAM | RNYSSAVQKF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SQTLQSFQFD | FIGDTLTDDE | INIAESFKEF | AELLNEVENE | RMMMVHNASD | LLIKPLENFR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KEQIGFTKER | KKKFEKDGER | FYSLLDRHLH | LSSKKKESQL | QEADLQVDKE | RHNFFESSLD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YVYQIQEVQE | SKKFNIVEPV | LAFLHSLFIS | NSLTVELTQD | FLPYKQQLQL | SLQNTRNHFS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| STREEMEELK | KRMKEAPQTC | KLPGQPTIEG | YLYTQEKWAL | GISWVKYYCQ | YEKETKTLTM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TPMEQKPGAK | QGPLDLTLKY | CVRRKTESID | KRFCFDIETN | ERPGTITLQA | LSEANRRLWM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EAMDGKEPIY | HSPITKQQEM | ELNEVGFKFV | RKCINIIETK | GIKTEGLYRT | VGSNIQVQKL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LNAFFDPKCP | GDVDFHNSDW | DIKTITSSLK | FYLRNLSEPV | MTYRLHKELV | SAAKSDNLDY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RLGAIHSLVY | KLPEKNREML | ELLIRHLVNV | CEHSKENLMT | PSNMGVIFGP | TLMRAQEDTV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AAMMNIKFQN | IVVEILIEHF | GKIYLGPPEE | SAAPPVPPPR | VTARRHKPIT | ISKRLLRERT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VFYTSSLDES | EDEIQHQTPN | GTITSSIEPP | KPPQHPKLPI | QRSGETDPGR | KSPSRPISDG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KLEPCPEVDV | GKLVSRLQDG | GTKITPKATN | GPMPGSGPTK | TPSFHIKRPA | PRPLAHHKEG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DADSFSKVRP | PGEKPTIIRP | PVRPPDPPCR | AATPQKPEPK | PDIVAGNAGE | ITSSVVASRT |
| 790 | 800 | ||||
| RFFETASRKT | GSSQGRLPGD | ES |